JACC:1型和2型心肌梗死患者的不同的临床特征和预后

2021-03-02 Nebula MedSci原创

心肌梗死可以分为几种类型:

心肌梗死可以分为几种类型:

1型是指与缺血相关的自发性心肌梗死,由一次原发性的冠脉事件(如斑块侵蚀和破裂、裂隙或夹层)引起;

2型是指继发于缺血的急性心肌梗死,由氧耗增加或氧供减少引起,如冠脉痉挛、冠脉栓塞、贫血、心律失常等;

3型指突发未预料到的心脏性死亡,包括心脏骤停;

4a型指伴发于PCI的心肌梗死;

4b型指伴发于支架内血栓形成的心肌梗死;

5型指伴发于冠脉搭桥的心肌梗死。

与1型心肌梗死相比,2型心肌梗死患者可能具有不同的临床特征和预后。本研究旨在比较美国1型心肌梗死患者和2型心肌梗死患者的临床特征和预后。

使用全国再入院数据库,对3个月内的心肌梗死患者进行分类。比较两组患者的基线特征以及住院和出院后的结果。

共纳入216657例1型MI患者和37765例2型MI患者,此外,还有1525例同时患有1型和2型MI的患者。

不同类型MI的发病率趋势

2型MI患者的年龄往往较大(71岁 vs 69岁;P<0.001),更可能是女性(47.3% vs 40%;P<0.001),心力衰竭(27.9% vs 10.9%;P<0.001)、肾脏疾病(35.7% vs 25.7%;P<0.001)和心房颤动(31% vs 21%;P<0.001)的患病率也更高。在2型MI患者中,冠状动脉造影(10.9% vs 57.3%;P<0.001)、经皮冠状动脉介入治疗(1.7% vs 38.5%;P<0.001)和冠状动脉旁路移植术(0.4% vs 7.8%;P<0.001)的发生率较低。

孤立性1型和2型MI患者再入院的最常见原因

2型MI患者的住院死亡率(调整后的优势比:0.57;95%CI:0.54-0.60])和30天MI再住院率(0.46;0.35-0.59])均较1型MI患者的低。此外,1型和2型MI患者的30天内全因或心力衰竭再入院风险没有差别。

总结图

综上所述,与1型MI患者相比,2型MI患者具有独特的血管表型,并以一种异质性的方式进行治疗

原始出处:

McCarthy Cian P,Kolte Dhaval,Kennedy Kevin F et al. Patient Characteristics and Clinical Outcomes of Type 1 Versus Type 2 Myocardial Infarction. J Am Coll Cardiol, 2021, 77: 848-857.

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    2021-09-20 hbwxf
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    2021-03-03 鼠叔叔啦啦

    糖尿病对比

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