JAMA:学龄前儿童ADHD药物治疗的比较

2021-05-10 MedSci原创 MedSci原创

接受哌醋甲酯治疗的学龄前儿童比接受胍法辛治疗的儿童易怒/情绪化率更高,胍法辛作为具有明显易怒和对立症状的学龄前ADHD儿童的首选药物。

对学龄前儿童注意缺陷多动症(ADHD)的认知在不断上升, 美国学龄前儿童ADHD患病率增加,从 2007年的1.0%增至2008年的2.4%。学龄前儿童(3–5岁)患ADHD将给家庭(例如,亲子关系混乱,家庭压力增加)以及外部环境(例如,学习前技能受损,同伴交往困难,被幼儿园和儿童保育机构开除) 带来大量的负面影响,这就显示了识别和治疗ADHD的重要性。美国儿科学会和发展行为儿科学会(SDBP)的指南推荐行为干预作为学龄前儿童多动症的一线治疗。行为干预本身并不能充分改善很大比例(80%)儿童的ADHD相关症状和障碍。当行为治疗不充分时,美国儿科学会指南推荐兴奋剂哌醋甲酯作为学龄前多动症儿童的初始药物治疗,因为在这个年龄组中,它是最有证据证明有效和安全的药物。然而,与学龄儿童相比,由于哌醋甲酯在学龄前儿童中的疗效下降和不良反应发生率较高,有时需要替代药物选择。因此,美国儿童和青少年精神病学学会的学龄前精神药理学工作组的一份指南建议,对于对兴奋剂药物治疗无反应或不耐受的学龄前ADHD儿童,使用α2肾上腺素能激动剂治疗。此外,根据目前的治疗模式和专家共识,SDBP Complex ADHD指

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1981241, encodeId=c4ca1981241de, content=<a href='/topic/show?id=8a344564298' target=_blank style='color:#2F92EE;'>#学龄前儿童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45642, encryptionId=8a344564298, topicName=学龄前儿童)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Dec 11 14:53:04 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779365, encodeId=52951e793651d, content=<a href='/topic/show?id=1a0819e9a0' target=_blank style='color:#2F92EE;'>#ADHD药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1979, encryptionId=1a0819e9a0, topicName=ADHD药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sat Sep 11 21:53:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970829, encodeId=bf489e08295b, content=过来学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210604/a2faf5e88d5f4b0a978c49153ad0164d/a8d3d0e027f64f49885f1c0b4206fd01.jpg, createdBy=a7395489243, createdName=石清, createdTime=Fri Jun 04 10:52:17 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307609, encodeId=160f130e60954, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Wed May 12 07:53:04 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036605, encodeId=37771036605ca, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon May 10 19:53:04 CST 2021, time=2021-05-10, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1981241, encodeId=c4ca1981241de, content=<a href='/topic/show?id=8a344564298' target=_blank style='color:#2F92EE;'>#学龄前儿童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45642, encryptionId=8a344564298, topicName=学龄前儿童)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Dec 11 14:53:04 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779365, encodeId=52951e793651d, content=<a href='/topic/show?id=1a0819e9a0' target=_blank style='color:#2F92EE;'>#ADHD药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1979, encryptionId=1a0819e9a0, topicName=ADHD药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sat Sep 11 21:53:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970829, encodeId=bf489e08295b, content=过来学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210604/a2faf5e88d5f4b0a978c49153ad0164d/a8d3d0e027f64f49885f1c0b4206fd01.jpg, createdBy=a7395489243, createdName=石清, createdTime=Fri Jun 04 10:52:17 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307609, encodeId=160f130e60954, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Wed May 12 07:53:04 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036605, encodeId=37771036605ca, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon May 10 19:53:04 CST 2021, time=2021-05-10, status=1, ipAttribution=)]
    2021-09-11 zz70
  3. [GetPortalCommentsPageByObjectIdResponse(id=1981241, encodeId=c4ca1981241de, content=<a href='/topic/show?id=8a344564298' target=_blank style='color:#2F92EE;'>#学龄前儿童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45642, encryptionId=8a344564298, topicName=学龄前儿童)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Dec 11 14:53:04 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779365, encodeId=52951e793651d, content=<a href='/topic/show?id=1a0819e9a0' target=_blank style='color:#2F92EE;'>#ADHD药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1979, encryptionId=1a0819e9a0, topicName=ADHD药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sat Sep 11 21:53:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970829, encodeId=bf489e08295b, content=过来学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210604/a2faf5e88d5f4b0a978c49153ad0164d/a8d3d0e027f64f49885f1c0b4206fd01.jpg, createdBy=a7395489243, createdName=石清, createdTime=Fri Jun 04 10:52:17 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307609, encodeId=160f130e60954, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Wed May 12 07:53:04 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036605, encodeId=37771036605ca, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon May 10 19:53:04 CST 2021, time=2021-05-10, status=1, ipAttribution=)]
    2021-06-04 石清

    过来学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1981241, encodeId=c4ca1981241de, content=<a href='/topic/show?id=8a344564298' target=_blank style='color:#2F92EE;'>#学龄前儿童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45642, encryptionId=8a344564298, topicName=学龄前儿童)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Dec 11 14:53:04 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779365, encodeId=52951e793651d, content=<a href='/topic/show?id=1a0819e9a0' target=_blank style='color:#2F92EE;'>#ADHD药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1979, encryptionId=1a0819e9a0, topicName=ADHD药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sat Sep 11 21:53:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970829, encodeId=bf489e08295b, content=过来学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210604/a2faf5e88d5f4b0a978c49153ad0164d/a8d3d0e027f64f49885f1c0b4206fd01.jpg, createdBy=a7395489243, createdName=石清, createdTime=Fri Jun 04 10:52:17 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307609, encodeId=160f130e60954, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Wed May 12 07:53:04 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036605, encodeId=37771036605ca, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon May 10 19:53:04 CST 2021, time=2021-05-10, status=1, ipAttribution=)]
    2021-05-12 lg.zhao
  5. [GetPortalCommentsPageByObjectIdResponse(id=1981241, encodeId=c4ca1981241de, content=<a href='/topic/show?id=8a344564298' target=_blank style='color:#2F92EE;'>#学龄前儿童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45642, encryptionId=8a344564298, topicName=学龄前儿童)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Dec 11 14:53:04 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779365, encodeId=52951e793651d, content=<a href='/topic/show?id=1a0819e9a0' target=_blank style='color:#2F92EE;'>#ADHD药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1979, encryptionId=1a0819e9a0, topicName=ADHD药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sat Sep 11 21:53:04 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970829, encodeId=bf489e08295b, content=过来学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210604/a2faf5e88d5f4b0a978c49153ad0164d/a8d3d0e027f64f49885f1c0b4206fd01.jpg, createdBy=a7395489243, createdName=石清, createdTime=Fri Jun 04 10:52:17 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307609, encodeId=160f130e60954, content=<a href='/topic/show?id=459f19e855' target=_blank style='color:#2F92EE;'>#ADHD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1978, encryptionId=459f19e855, topicName=ADHD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Wed May 12 07:53:04 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036605, encodeId=37771036605ca, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon May 10 19:53:04 CST 2021, time=2021-05-10, status=1, ipAttribution=)]
    2021-05-10 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

相关资讯

FDA批准用于治疗ADHD的Adhansia XR(盐酸哌甲酯)缓释胶囊CII

Adlon制药公司近日宣布美国食品和药品监督管理局(FDA)已经批准Adhansia XR™(盐酸哌甲酯)缓释胶囊CII(一种中枢神经系统(CNS)调节剂),用于治疗六岁及以上注意缺陷多动障碍(ADHD)的患者。在AWE研究中,Adhansia XR在给药后的第1、2、5、8、11和16小时显示出相对于安慰剂的统计学显著改善。

Nat Gene:新研究发现一批多动症相关基因

一个国际研究团队近日宣布,他们发现了一批与“注意力缺陷多动障碍(俗称多动症)”发病风险有关的基因变异。这为探究多动症背后的生物学机制提供了新见解,有助于对该病的诊断与治疗。

癫痫患儿注意缺陷多动障碍筛查、诊断和管理的系统评价:国际抗癫痫联盟儿科委员会共病工作组共识

这份由国际癫痫联盟(ILAE)儿科委员会制定的共识旨在提供基于证据的指导,为癫痫患儿 ADHD的筛查、诊断和管理提供临床实践依据。本文为该专家共识的中文翻译内容。

NEJM:多动症患者用哌醋甲酯或安非他明治疗相关的精神病

由此可见,在接受兴奋剂处方的ADHD青少年和年轻成人中,660名患者中约有1人出现新发精神病。安非他明的使用与哌醋甲酯相比具有更高的精神病风险。

JAMA Psychiatry:孕期贫血宝宝出生后患自闭症、多动症、智力障碍的风险增加

鉴于铁在神经发育中具有关键作用,研究人员推测产前缺铁可能与胎儿出生后患神经发育障碍风险有关,如自闭症谱系障碍(ASD)、注意力缺陷/多动障碍(ADHD)和智力障碍(ID)。现研究人员对孕期母体贫血与子女罹患ASD、ADHD和ID的风险的相关性进行研究。研究人员对瑞典1987年1月1日-2010年12月31日期间出生的532 232位儿童进行研究,随访至2016年12月31日。筛查孕期贫血的诊断,并

Thyroid:早孕期孕妇甲状腺功能与儿童注意力缺陷多动障碍的关系

由此可见,该研究没有发现孕妇甲状腺功能与儿童多动症之间存在关联的明确证据。