Nat Commun:在胎盘中观察到黑碳颗粒

2019-09-21 Nature自然科研 Nature自然科研

本周《自然-通讯》发表了一项覆盖28名女性的观察性研究Ambient black carbon particles reach the fetal side of human placenta,研究显示在孕期暴露于空气污染的女性中,其胎盘靠胎儿一侧可发现黑碳颗粒。不过,还需要开展进一步的研究来明确这些颗粒是否能够抵达胎儿。

本周《自然-通讯》发表了一项覆盖28名女性的观察性研究Ambient black carbon particles reach the fetal side of human placenta,研究显示在孕期暴露于空气污染的女性中,其胎盘靠胎儿一侧可发现黑碳颗粒。不过,还需要开展进一步的研究来明确这些颗粒是否能够抵达胎儿。



检测胎盘中黑炭颗粒的实验方案流程图  来源: Bové et al.

黑碳颗粒主要来自化石燃料的燃烧,每天都会被释放进周围空气中。已知这类颗粒对妊娠结局具有有害影响;例如,它们与早产或低出生体重相关。为了改善污染地区的孕期护理,必须弄清楚这些颗粒如何影响妊娠——直接作用于胎儿还是通过母体间接作用。

比利时哈塞尔特大学的Tim Nawrot及同事提供证据表明,黑碳颗粒可以在妊娠期间抵达胎盘胎儿侧。他们利用高分辨率成像技术,从5例早产和23例足月生产的胎盘中检测到了黑碳颗粒。作者发现,10位女性在孕期暴露于居住环境中的高水平黑碳颗粒(2.42微克/立方米)之下,另有10位暴露于低水平黑碳颗粒之下(0.63微克/立方米),并且在前者的胎盘中发现的黑碳颗粒水平也更高。

与孕期空气污染暴露相关的负面影响,是否可能源自黑碳颗粒在胎盘组织中的累积,要阐明这个问题,还需要开展额外的研究。

Tim Nawrot及同事在《临床表观遗传学》(Clinical Epigenetics)上发表了一篇综述文章,概述了由空气污染引起的胎盘中的分子变化,包括表观遗传变化。

原始出处:
Hannelore Bové, Eva Bongaerts, Eli Slenders, et al. Ambient black carbon particles reach the fetal side of human placenta. Nature Communications. 17 September 2019.


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    2020-07-24 1240394fm61暂无昵称

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    2020-06-09 liuli5079
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