Diabetes Care:1型糖尿病患者终末期肾病的发生率分析!

2017-12-21 xing.T MedSci原创

由此可见,ESRD的累积风险在过去50年间显著下降。这凸显了当代治疗糖尿病和糖尿病肾病的重要性。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在明确1型糖尿病患者发生终末期肾病(ESRD)的风险是如何随着时间的推移而改变的,并进一步了解年龄、性别和糖尿病诊断时间对风险产生何种影响。

该研究纳入了1965至2011年间在芬兰诊断为1型糖尿病的所有患者(30岁以下),随访至开始进行肾替代治疗、死亡或2013年底随访结束。该研究总共有29906名患者被纳入分析。主要结局指标为ESRD的累积风险,认为死亡是一个竞争风险。

该研究的患者中位随访时间位20年。在616403例患者每年的随访期间,共记录到了1543例ESRD患者和4185例死亡病例。自糖尿病诊断起20年后ESRD的累积风险率为2.2%,30年后为7%。在1995至2011年期间诊断的患者相比于1965至1979年期间诊断的患者发生ESRD相对危险度为0.13(95%可信区间位0.08-0.22)。确诊时小于5岁的患者诊断ESRD的风险最低。随着出生时间估计的ESRD的累积风险,5至9岁时诊断位糖尿病的患者发生ESRD的风险最高。

由此可见,ESRD的累积风险在过去50年间显著下降。这凸显了当代治疗糖尿病和糖尿病肾病的重要性。

原始出处:

Jaakko Helve,et al. Incidence of End-Stage Renal Disease in Patients With Type 1 Diabetes.Diabetes Care 2017. https://doi.org/10.2337/dc17-2364

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    2018-01-25 一叶知秋
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