杀死乳腺癌细胞!“网红抗癌药”Venetoclax再显奇效

2020-05-21 汉鼎好医友 汉鼎好医友

网络抗癌药不但能治淋巴瘤,还能对乳腺癌细胞造成杀伤。

还记得曾经刷爆朋友圈的“澳洲抗癌神Venetoclax”吗?

这款新药是由澳洲和美国科学家共同研发,它能以“融化”的方式消灭癌细胞。临床试验中,79%患有慢性淋巴癌的病人对Venetoclax都表现出积极应答,小部分人甚至在参与试验后痊愈,另有20%既往接受过治疗但失效的患者,在参加试验后体内竟找不到癌细胞的踪影了!

外媒曾报道过一位63岁的白血病患者,他脖子上长了高尔夫球大小的肿瘤,胳膊下的肿瘤跟葡萄柚差不多大,每天要昏睡20个小时,估计活不过3周。然而,在参与试验服用Venetoclax两年后,他奇迹般地重新回到了工作中,过上了正常人的生活。

2016年4月,FDA加速批准Venetoclax用于伴17p缺失的复发难治性慢性淋巴细胞白血病(CLL)的治疗。

Venetoclax有啥“过人之处”?

传统的化疗药物通常不加区分地攻击快速分裂的细胞来抑制癌细胞的扩散,但这种“杀敌一千,自损八百”的治疗方式,也会伤害到正常细胞如血液细胞、肠道细胞和头发毛囊,导致一系列副作用。

而Venetoclax作为全球首个特异针对BCL-2蛋白的新型口服靶向药,几乎不会引起这类副作用,原因在于它通过使癌瘤中的BCL-2蛋白失活,启动癌细胞自杀。BCL-2是一种能抑制细胞(包括癌细胞)凋亡的蛋白,癌肿瘤中BCL-2蛋白的存在阻止了肿瘤细胞凋亡。Venetoclax采用表观遗传BET抑制法,从基因层面治疗癌症的方式,完全颠覆了传统化疗方式。

Venetoclax用于乳腺癌疗效可期

根据Walter和Eliza Hall Institute研究人员领导的临床前研究,抗癌药物Venetoclax可以改善目前对雌激素受体阳性(ER +)乳腺癌的治疗方法。

该研究小组表明,Venetoclax可以杀死被CDK4/6抑制剂(一种阻断细胞分裂的药物)“休眠”的乳腺癌细胞,这种药物目前与激素疗法一起用于治疗ER+乳腺癌。这项研究使用了从患者身上获取的乳腺癌细胞,这是第一个表明Venetoclax可以杀死“休眠”癌细胞的研究。

这种“三联疗法”的临床前研究结果为在墨尔本进行的一期临床试验奠定了基础,该试验将Venetoclax与激素疗法和CDK4/6抑制剂联合应用于ER+乳腺癌患者。

研究者解释,目前复发性ER+乳腺癌治疗的“金标准”是抗激素疗法(内分泌疗法)联合CDK4/6抑制剂。这种组合疗法在减缓癌症生长方面效果很好,但实际上并不能杀死癌细胞,它只会使它们进入休眠状态。遗憾的是,这意味着癌症的复发实际上不可避免。如果我们能找到一种方法来杀死这些沉睡的癌细胞,也许就可以帮助患者更长寿。为此,我们选择了直接阻断助癌生存的蛋白质的药物。

研究小组检查了ER +乳腺癌细胞是否对Venetoclax敏感,他们发现Venetoclax确实可以杀死用CDK4 / 6抑制剂治疗过的ER +乳腺癌细胞,甚至是休眠的癌细胞。这一结果令人振奋,这是Venetoclax首次被证明可以杀死休眠细胞。

患者ER +乳腺癌样本模型显示,在内分泌疗法和CDK4/6抑制剂联合疗法中加入Venetoclax,可以使肿瘤对治疗产生更好、更长期的反应。

目前,一项名为PALVEN的1期临床试验已启动,将研究这种三联疗法的安全性和有效性。对于ER +乳腺癌患者而言,这种有望改善预后的新疗法值得期待。

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    2021-04-04 canlab
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    2020-05-23 yxch36
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    2020-05-23 sunylz
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    2020-05-23 caoliehu
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    2020-05-21 lovetcm

    夸张吧

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导言:据2018年国际癌症研究机构(IARC)调查的最新数据显示,乳腺癌在全球女性癌症中的发病率为24.2%,位居女性癌症的首位,其中52.9%发生在发展中国家。在我国,乳腺癌的发病率呈逐年上升趋势,