JAHA:糖尿病、高血压、血脂异常、卒中或心肌梗死家族史与川崎病发病风险的关系

2022-06-16 MedSci原创 MedSci原创

在这项全国性倾向评分匹配研究中,伴有心血管疾病家族史的患者与无心血管疾病家族史的患者相比,川崎病的发病风险显著增加。

川崎病是一种引起所有中动脉和多器官组织全身性炎症的急性发热性疾病。在大多数工业化国家,这种疾病是儿童获得性心脏病最常见的病因。但是关于儿童川崎病与家族心血管疾病(CVD)之间的相关性研究较少。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的目的是明确川崎病风险增加与心血管疾病家族史之间的关联。

2008年和2009年出生的儿童(n=917707)的临床资料来自全国健康保险服务和全国婴幼儿健康筛查计划。该队列纳入了495215名参与者(53.8%),他们完成了54-60个月儿童的家族史问卷。心血管疾病家族史包括高血压、血脂异常、心肌梗死卒中糖尿病等5种疾病。根据疾病代码、静脉注射免疫球蛋白处方、使用退烧药25天以上来确定川崎病。重度川崎病定义为伴有心脏/冠状动脉并发症或静脉注射免疫球蛋白2次及以上。

2岁以下儿童川崎病发病率为124/10万人每年(95%CI为117.5-131.5),2-5岁儿童为95/10万人每年(95%CI为90.5-100.4),5岁以上儿童为14/10万人每年(95%CI为12.6-15.6)。在倾向评分匹配后,829名有CVD家族史的参与者被诊断为川崎病(0.68%[95%CI为0.63-0.72]),690名川崎病患者(0.56%[95%CI为0.52-0.61])没有CVD家族史。伴有CVD家族史者川崎病发病风险增高(风险比为1.20[95%CI为1.08-1.32]),但对于严重川崎病的发病风险则不然,其风险比为1.23[95%CI为0.92-1.65])。

由此可见,在这项全国性倾向评分匹配研究中,伴有心血管疾病家族史的患者与无心血管疾病家族史的患者相比,川崎病的发病风险显著增加。

原始出处:

Ji Hee Kwak.et al.Association of Familial History of Diabetes, Hypertension, Dyslipidemia, Stroke, or Myocardial Infarction With Risk of Kawasaki Disease.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.023840

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1820526, encodeId=57ae1820526f0, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Sep 05 19:23:42 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253797, encodeId=974d1253e97f4, content=<a href='/topic/show?id=cbd48992056' target=_blank style='color:#2F92EE;'>#血脂异常#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89920, encryptionId=cbd48992056, topicName=血脂异常)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268847, encodeId=3487126884ec4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479828, encodeId=bdb014e9828b2, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1820526, encodeId=57ae1820526f0, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Sep 05 19:23:42 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253797, encodeId=974d1253e97f4, content=<a href='/topic/show?id=cbd48992056' target=_blank style='color:#2F92EE;'>#血脂异常#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89920, encryptionId=cbd48992056, topicName=血脂异常)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268847, encodeId=3487126884ec4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479828, encodeId=bdb014e9828b2, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1820526, encodeId=57ae1820526f0, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Sep 05 19:23:42 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253797, encodeId=974d1253e97f4, content=<a href='/topic/show?id=cbd48992056' target=_blank style='color:#2F92EE;'>#血脂异常#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89920, encryptionId=cbd48992056, topicName=血脂异常)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268847, encodeId=3487126884ec4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479828, encodeId=bdb014e9828b2, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=)]
    2022-06-17 zhaohui6731
  4. [GetPortalCommentsPageByObjectIdResponse(id=1820526, encodeId=57ae1820526f0, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Sep 05 19:23:42 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253797, encodeId=974d1253e97f4, content=<a href='/topic/show?id=cbd48992056' target=_blank style='color:#2F92EE;'>#血脂异常#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89920, encryptionId=cbd48992056, topicName=血脂异常)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=bugit, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268847, encodeId=3487126884ec4, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479828, encodeId=bdb014e9828b2, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 17 14:23:42 CST 2022, time=2022-06-17, status=1, ipAttribution=)]

相关资讯

JACC:高血糖大大推进亚临床心衰的进展!

在亚临床心衰的老年人中,控制不佳的糖尿病与心衰进展的高风险密切相关

Clin Nutrition:限制碳水化合物导致的体重减轻不会对2型糖尿病患者的生活质量和认知产生负面影响

碳水化合物主要是来源于主食,是影响血糖的主要营养因素,碳水化合物根据对血糖的影响大小,分为高升糖指数食物、中升糖指数食物和低升糖指数食物。

Diabetologia:长期生活方式干预对糖尿病前期成人体重和心脏代谢健康标志物的年龄和性别特异性影响

作为肥胖的一线治疗选择,生活方式干预在几项大规模研究中被证明有助于减肥和改善心脏代谢健康指标。

Eur J Endocrinol:小RNA在自身免疫性和非自身免疫性糖尿病和对照组中差异表达

LADA的病理生理学和遗传特征远不如它的同类1型和2型糖尿病那样为人所知。

Diabetologia:抑郁症、糖尿病、抑郁症和糖尿病共病以及全因和特定原因死亡风险

有证据表明,在1型或2型糖尿病患者中,抑郁与全因死亡率风险之间的关联可能比非1型或非1型患者更明显,但很少有研究调查抑郁和糖尿病对死亡率风险的单独和联合影响。

Br J Cancer :家族史、肥胖、泌尿系统因素和糖尿病药物与前列腺癌诊断风险的关系

有新的证据表明,用于治疗糖尿病的药物与包括PC在内的一系列恶性肿瘤的风险有关。