Circulation:基础利尿剂应用对达格列净治疗心衰时的疗效的影响

2020-09-18 Nebula-Qin MedSci原创

研究表明,钠葡萄糖共转运体2抑制剂达格列净降低了射血分数降低的心衰患者的心衰恶化和死亡风险。本研究拟评估达格列净与基础利尿剂治疗和达格列净对利尿剂剂量的影响。

在DAPA-HF试验(达格列净和预防心力衰竭的不良后果)中,钠葡萄糖共转运体2抑制剂达格列净降低了射血分数降低的心衰患者的心衰恶化和死亡风险。近日,《Circulation》发表了一篇新的文章,研究人员评估了达格列净与基础利尿剂治疗和随机分配到达格列净组或安慰剂组后的利尿方案的改变。

分组情况:起始时,未使用利尿剂,利尿剂剂量相当于速尿的<40 mg、40 mg和>40 mg。研究人员评估了主要复合终点,包括血管死亡或恶化性心衰事件、全因死亡和症状。

在4616位受试患者中,736位(15.9%)未采用利尿剂治疗,1311位(28.4%)利尿剂剂量<40 mg、1365位(39.6%) 40 mg和1204位(26.1%)服用>40 mg的利尿剂。相比安慰剂组,达格列净可降低所有亚组的主要终点风险:风险比[HR]分别是0.57(95% CI 0.36-0.92)、0.83 (0.63–1.10)、0.77 (0.60–0.99)和0.78 (0.63–0.97)。服用任何利尿剂的患者的HR为0.78(95 CI 0.68-0.97)。各利尿剂组的症状和治疗耐受的改善一致。

(安慰剂组和达格列净组的利尿剂剂量)

随访过程中,大部分患者的利尿剂剂量未改变,达格列净组和安慰剂组的平均利尿剂剂量无差别。

综上所述,达格列净在DAPA-HF试验中的各利尿剂亚组中的疗效和安全性一致。

原始出处:

Alice M. Jackson, et al. Dapagliflozin and Diuretic Use in Patients With Heart Failure and Reduced Ejection Fraction in DAPA-HF. Circulation. 2020;142:1040–1054

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channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200618/47e172bce1cc4da5ab6d5e886bd6b9d9/25cba073cbc94c3dad32d0c132ef6a75.jpg, createdBy=f25d5390775, createdName=ms3000001780497766, createdTime=Sun Nov 22 23:49:58 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901285, encodeId=3ef1901285f1, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sun Nov 22 21:57:27 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888235, encodeId=b6b7888235f4, 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    2021-02-22 言西早

    有利于患者治疗。

    0

  2. 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    2021-01-25 zt123

    构建人类命运共同体

    0

  3. 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    2020-09-18 lovetcm

    #达格列净#治疗#心力衰竭#与利尿剂无关

    1

    展开1条回复
  4. 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25 12:42:27 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886429, encodeId=aa4788642915, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>治疗<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>与利尿剂无关, beContent=null, objectType=article, channel=null, level=null, likeNumber=255, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净), TopicDto(id=50884, encryptionId=072c5088466, topicName=心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 17:33:23 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901305, encodeId=f6b29013053d, content=不错👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200618/47e172bce1cc4da5ab6d5e886bd6b9d9/25cba073cbc94c3dad32d0c132ef6a75.jpg, createdBy=f25d5390775, createdName=ms3000001780497766, createdTime=Sun Nov 22 23:49:58 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901285, encodeId=3ef1901285f1, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sun Nov 22 21:57:27 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888235, encodeId=b6b7888235f4, content=钠葡萄糖共转运体2抑制剂达格列净降低了射血分数降低的心衰患者的心衰恶化和死亡风险。加入药物经济学部分如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:39:13 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886973, encodeId=dd058869e3e3, content=利尿剂在心衰治疗中起很重要的作业, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200617/463f3da08d884f7fb6559a1b5a7e79b5/f95c20e8ab9649fe9e4f817a5c9328b4.jpg, createdBy=1da25389887, createdName=Bertvon, createdTime=Sun Sep 20 23:54:14 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271962, encodeId=251812e196282, content=<a href='/topic/show?id=573332291bd' target=_blank style='color:#2F92EE;'>#利尿剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32291, encryptionId=573332291bd, topicName=利尿剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Sep 20 05:03:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886731, encodeId=a713886e3132, content=达格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:31:39 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886462, encodeId=1db888646219, content=研究需要不断向前推进, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/w48m4tfuUqW9dUIzh9NYRIDJ0GtYduMWXHEpc76V4fzTaGmaX7KzfsOyVjiczqUAUa0P00dY9ibfkLibmXTOARvpw/132, createdBy=699a2354088, createdName=renwj, createdTime=Fri Sep 18 20:14:16 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-11-22 ms3000001780497766

    不错👍

    0

  5. 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channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200618/47e172bce1cc4da5ab6d5e886bd6b9d9/25cba073cbc94c3dad32d0c132ef6a75.jpg, createdBy=f25d5390775, createdName=ms3000001780497766, createdTime=Sun Nov 22 23:49:58 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901285, encodeId=3ef1901285f1, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sun Nov 22 21:57:27 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888235, encodeId=b6b7888235f4, content=钠葡萄糖共转运体2抑制剂达格列净降低了射血分数降低的心衰患者的心衰恶化和死亡风险。加入药物经济学部分如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:39:13 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886973, encodeId=dd058869e3e3, content=利尿剂在心衰治疗中起很重要的作业, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200617/463f3da08d884f7fb6559a1b5a7e79b5/f95c20e8ab9649fe9e4f817a5c9328b4.jpg, createdBy=1da25389887, createdName=Bertvon, createdTime=Sun Sep 20 23:54:14 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271962, encodeId=251812e196282, content=<a href='/topic/show?id=573332291bd' target=_blank style='color:#2F92EE;'>#利尿剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32291, encryptionId=573332291bd, topicName=利尿剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Sep 20 05:03:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886731, encodeId=a713886e3132, content=达格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:31:39 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886462, encodeId=1db888646219, content=研究需要不断向前推进, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/w48m4tfuUqW9dUIzh9NYRIDJ0GtYduMWXHEpc76V4fzTaGmaX7KzfsOyVjiczqUAUa0P00dY9ibfkLibmXTOARvpw/132, createdBy=699a2354088, createdName=renwj, createdTime=Fri Sep 18 20:14:16 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-11-22 Ash.L

    懂了

    0

  6. 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channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200618/47e172bce1cc4da5ab6d5e886bd6b9d9/25cba073cbc94c3dad32d0c132ef6a75.jpg, createdBy=f25d5390775, createdName=ms3000001780497766, createdTime=Sun Nov 22 23:49:58 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901285, encodeId=3ef1901285f1, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sun Nov 22 21:57:27 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888235, encodeId=b6b7888235f4, 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href='/topic/show?id=573332291bd' target=_blank style='color:#2F92EE;'>#利尿剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32291, encryptionId=573332291bd, topicName=利尿剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Sep 20 05:03:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886731, encodeId=a713886e3132, content=达格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:31:39 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886462, encodeId=1db888646219, content=研究需要不断向前推进, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/w48m4tfuUqW9dUIzh9NYRIDJ0GtYduMWXHEpc76V4fzTaGmaX7KzfsOyVjiczqUAUa0P00dY9ibfkLibmXTOARvpw/132, createdBy=699a2354088, createdName=renwj, createdTime=Fri Sep 18 20:14:16 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-25 咻凡

    钠葡萄糖共转运体2抑制剂达格列净降低了射血分数降低的心衰患者的心衰恶化和死亡风险。加入药物经济学部分如何?

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=926478, encodeId=2bc89264e8c5, content=有利于患者治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Mon Feb 22 22:44:25 CST 2021, time=2021-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919671, encodeId=795f9196e153, content=构建人类命运共同体, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKXpC8j9TaoCpG4yIB3skibUZ0ricmVQ6KKIVpqYQxINrmlibsPZSia7GOUupzuINf8UITMib8awsjjkPw/0, createdBy=abbf1713451, createdName=zt123, createdTime=Mon Jan 25 12:42:27 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886429, encodeId=aa4788642915, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>治疗<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>与利尿剂无关, beContent=null, objectType=article, channel=null, level=null, likeNumber=255, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净), TopicDto(id=50884, encryptionId=072c5088466, topicName=心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 17:33:23 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901305, encodeId=f6b29013053d, content=不错👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200618/47e172bce1cc4da5ab6d5e886bd6b9d9/25cba073cbc94c3dad32d0c132ef6a75.jpg, createdBy=f25d5390775, createdName=ms3000001780497766, createdTime=Sun Nov 22 23:49:58 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901285, encodeId=3ef1901285f1, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sun Nov 22 21:57:27 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888235, encodeId=b6b7888235f4, content=钠葡萄糖共转运体2抑制剂达格列净降低了射血分数降低的心衰患者的心衰恶化和死亡风险。加入药物经济学部分如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:39:13 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886973, encodeId=dd058869e3e3, content=利尿剂在心衰治疗中起很重要的作业, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200617/463f3da08d884f7fb6559a1b5a7e79b5/f95c20e8ab9649fe9e4f817a5c9328b4.jpg, createdBy=1da25389887, createdName=Bertvon, createdTime=Sun Sep 20 23:54:14 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271962, encodeId=251812e196282, content=<a href='/topic/show?id=573332291bd' target=_blank style='color:#2F92EE;'>#利尿剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32291, encryptionId=573332291bd, topicName=利尿剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Sep 20 05:03:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886731, encodeId=a713886e3132, content=达格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:31:39 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886462, encodeId=1db888646219, content=研究需要不断向前推进, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/w48m4tfuUqW9dUIzh9NYRIDJ0GtYduMWXHEpc76V4fzTaGmaX7KzfsOyVjiczqUAUa0P00dY9ibfkLibmXTOARvpw/132, createdBy=699a2354088, createdName=renwj, createdTime=Fri Sep 18 20:14:16 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-20 Bertvon

    利尿剂在心衰治疗中起很重要的作业

    0

  8. 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channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200618/47e172bce1cc4da5ab6d5e886bd6b9d9/25cba073cbc94c3dad32d0c132ef6a75.jpg, createdBy=f25d5390775, createdName=ms3000001780497766, createdTime=Sun Nov 22 23:49:58 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901285, encodeId=3ef1901285f1, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sun Nov 22 21:57:27 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888235, encodeId=b6b7888235f4, 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href='/topic/show?id=573332291bd' target=_blank style='color:#2F92EE;'>#利尿剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32291, encryptionId=573332291bd, topicName=利尿剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Sep 20 05:03:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886731, encodeId=a713886e3132, content=达格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:31:39 CST 2020, time=2020-09-19, status=1, ipAttribution=), 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  9. 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channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200618/47e172bce1cc4da5ab6d5e886bd6b9d9/25cba073cbc94c3dad32d0c132ef6a75.jpg, createdBy=f25d5390775, createdName=ms3000001780497766, createdTime=Sun Nov 22 23:49:58 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901285, encodeId=3ef1901285f1, content=懂了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201022/72c91d73e2ce4d7b9c5c2632e334c6f9/2ca937aa7ec64d0a834d958d18104b30.jpg, createdBy=77a62581282, createdName=Ash.L, createdTime=Sun Nov 22 21:57:27 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888235, encodeId=b6b7888235f4, 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href='/topic/show?id=573332291bd' target=_blank style='color:#2F92EE;'>#利尿剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32291, encryptionId=573332291bd, topicName=利尿剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Sep 20 05:03:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886731, encodeId=a713886e3132, content=达格列净, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 19 22:31:39 CST 2020, time=2020-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886462, encodeId=1db888646219, content=研究需要不断向前推进, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/w48m4tfuUqW9dUIzh9NYRIDJ0GtYduMWXHEpc76V4fzTaGmaX7KzfsOyVjiczqUAUa0P00dY9ibfkLibmXTOARvpw/132, createdBy=699a2354088, createdName=renwj, createdTime=Fri Sep 18 20:14:16 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-19 Nebula-Qin

    达格列净

    0

  10. 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content=钠葡萄糖共转运体2抑制剂达格列净降低了射血分数降低的心衰患者的心衰恶化和死亡风险。加入药物经济学部分如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:39:13 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886973, encodeId=dd058869e3e3, content=利尿剂在心衰治疗中起很重要的作业, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200617/463f3da08d884f7fb6559a1b5a7e79b5/f95c20e8ab9649fe9e4f817a5c9328b4.jpg, createdBy=1da25389887, createdName=Bertvon, createdTime=Sun Sep 20 23:54:14 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271962, encodeId=251812e196282, content=<a 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    2020-09-18 renwj

    研究需要不断向前推进

    0

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