JAHA:甘油三酯和甘油三酯/HDL比率可预测非阻塞性冠状动脉疾病女性主要不良心血管结局

2019-04-24 xing.T 网络

由此可见,甘油三酯水平可能在预测女性心血管特异性风险中起关键作用,他汀类药物的使用可能具有保护作用。需要进一步调查以更好地描述他汀类药物在预防心血管风险中的作用。

非梗阻性冠状动脉疾病女性患者血管疾病的发病率增加,危险因素在这一人群的作用尚未确定。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员的目的是探究甘油三酯和甘油三酯/高密度脂蛋白比率对非阻塞性冠状动脉疾病患者主要不良心血管事件(MACE)的预测作用,并探讨降脂治疗在改善这种风险中的作用。

这是一项前瞻性队列研究,纳入了转诊至心脏导管室接受治疗的疑似缺血的心绞痛患者,随后被诊断为非阻塞性冠状动脉疾病,定义为血管造影狭窄不超过20%。所有患者均进行基线实验室检查,随访7.8±4.3年,观察主要不良心血管事件的情况。研究人员进行了Cox比例风险评估,以确定甘油三酯对根据基线他汀类药物使用分组的男性和女性主要不良心血管事件风险的影响。

该研究共纳入了462名患者。中位年龄为53岁(Q1,Q3:45,62)岁。在使用他汀类药物调整混杂因素的Cox比例风险模型中,在基线他汀类药物中,甘油三酯可独立预测女性主要不良心血管事件(每增加50mg/dL的风险比为1.25[95%CI为1.06-1.47;P=0.01)。而男性则不是这样。甘油三酯与性别、甘油三酯和他汀类药物之间的相互作用具有统计学意义。

由此可见,甘油三酯水平可能在预测女性心血管特异性风险中起关键作用,他汀类药物的使用可能具有保护作用。需要进一步调查以更好地描述他汀类药物在预防心血管风险中的作用。 

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    2019-10-18 tomyang96
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    2019-04-26 仁心济世
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    2019-04-26 ZGMFX24A
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    2019-04-25 1209e435m98(暂无昵称)

    学习了,谢谢分享

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    2019-04-25 183****7028

    学习

    0

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