J Rheumatol:增强超声监测大动脉炎的动脉炎症

2019-03-14 xiangting MedSci原创

对于临床上不活动的TA患者,CEUS可以帮助医生识别颈动脉血管区域的活动性病变。

这项研究旨在评估与18F-氟脱氧葡萄糖-正电子发射断层扫描(FDG-PET)比较,对比增强超声(CEUS)在评估大动脉炎(TA)血管炎症方面的效用。

回顾性分析了71例接受颈动脉CEUS的TA患者。71例患者中有22例在CEUS后接受FDG-PET检查。通过Kerr标准和2010年印度大动脉炎临床活动性评分(ITAS2010)评估临床疾病活动性。还研究了CEUS颈动脉血管化与临床数据间的相关性。分析了不同TA疾病活动性时颈动脉CEUS和PET数据的一致性。

CEUS结果和ITAS2010(p=0.004)或Kerr标准(p<0.001)之间存在统计学显著相关性。根据ITAS2010,71例TA患者中有34例为临床非活动性。对临床非活动性的34例TA患者进行评估,其中11次CEUS扫描显示为左侧或右侧颈动脉活动性病变(视觉等级≥2)。22例接受CEUS和FDG-PET检查的患者中,根据ITAS2010,12例为活动性,10例非活动性。此外,在这些TA患者中双侧颈动脉CEUS血管化评分与血管FDG摄取呈正相关(p=0.004)。当血管炎症被定义为FDG摄取视觉等级≥2时,颈动脉CEUS的敏感性为100%、特异性80%。

对于临床上不活动的TA患者,CEUS可以帮助医生识别颈动脉血管区域的活动性病变。颈动脉CEUS可作为TA患者随访中一种快速且具有成本-效益的成像工具。

原始出处:

ZhiQin Li. Contrast-enhanced Ultrasonography for Monitoring Arterial Inflammation in Takayasu Arteritis. J Rheumatol. 01 March 2019.

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