TAG: 年龄影响炎症性肠病患者的疾病特征和治疗选择吗?

2021-03-20 MedSci原创 MedSci原创

年轻患者炎症性肠病(IBD)的发病率,例如克罗恩病(CD)和溃疡性结肠炎(UC),在世界范围内正在增加。多达20%的IBD病例在18岁之前被诊断出。

      年轻患者炎症性肠病(IBD)的发病率,例如克罗恩病(CD)和溃疡性结肠炎(UC),在世界范围内正在增加。多达20%的IBD病例在18岁之前被诊断出。青春期是人一生中最具独特发展和心理变化的时期,其特征还在于患者的自主性和心理脆弱性不断增加,而且这部分患者对药物治疗的依从性通常较差,因此,对这些患者的持续指导和支持对于改善依从性至关重要。在这项研究中,研究人员旨在评估患有IBD的匈牙利青少年人群的临床表型的差异和治疗特征,以填补有关此类患者的临床和治疗特征的知识空白。

 

 

 

      研究人员分析了匈牙利国家健康保险基金数据库中关于炎症性肠病的相关数据,纳入了在数据库中可观察到的2009年至2016年数据的IBD青春期患者。年龄在14至17岁和18至21岁的患者被定义为青少年中期和晚期。对所有患者的临床和治疗特征进行了分析。

 

 

 

      研究结果显示IBD的发生率是每100,000名中青年中有20.12的患病率。相比于外科手术治疗,青春期IBD患者的更愿意进行消化内科的住院治疗。在克罗恩病和溃疡性结肠炎患者中美沙拉嗪是使用比例最高的药物。青少年期患者的皮质类固醇使用率没有明显差异,并且随着时间的流逝呈下降趋势。中青年患者对生物制剂的需求较高。中青年组接受抗TNF治疗的患者比例呈上升趋势。

 

 

 

      本项研究数据表明,中青年组对生物制剂的需求较高,尤其是对TNF治疗的需求更大,这表明在过渡到成人阶段之前的青少年患者可能具有更严重的疾病表型。

 

 

 

原始出处:

Kata Judit Szántó. Et al. Does inflammatory bowel disease have different characteristics according to stage of adolescence?Therapeutic Advances in Gastroenterology.2021.

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    2021-03-21 ms6000000587866191

    学习

    0

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    2021-03-20 水-晶

    进来看看了

    0

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