Diabetes Care:抑郁症与1型糖尿病患者糖尿病肾病进展有关

2020-11-13 MedSci原创 MedSci原创

诊断为抑郁症和购买抗抑郁药与1型糖尿病患者糖尿病肾病的进展有关,需要进一步明确成功治疗抑郁症是否可以降低其风险。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,这项研究旨在调查抑郁症与1型糖尿病患者糖尿病肾病进展之间的关系。

研究人员纳入了3730名基线时无终末期肾脏疾病(ESRD)的参与者数据,这些参与者参加了芬兰糖尿病肾病研究。研究人员通过三种方式评估了参与者的抑郁症情况。抑郁症诊断来自芬兰卫生保健登记中心。抗抑郁药的购买数据是从药品处方登记处获得的。研究人员使用贝克抑郁量表(BDI)评估参与者抑郁症状。根据他们的尿白蛋白排泄率(AER),将参与者分为AER正常、微量白蛋白尿和大量白蛋白尿。随访期间进展分为从正常AER到微白蛋白尿、大量白蛋白尿或ESRD;从微量白蛋白尿到大量白蛋白尿或ESRD;或从大量白蛋白尿到ESRD。

在平均9.6年的随访期内,有18.4%的参与者肾脏状况恶化。在基线之前诊断出抑郁症和购买过抗抑郁药的参与者糖尿病肾病进展的风险分别增加了53%和32%。随访期间诊断抑郁症仍然与疾病进展的风险增加相关(32%)。BDI引起的抑郁症状与病情发展无关,但购买抗抑郁药的总人数适度降低了风险(风险比为0.989 [95%CI为0.982-0.997],P=0.008)。抑郁症症状还可以预测年龄≤36.5岁的患者的病情发展。

由此可见,诊断为抑郁症和购买抗抑郁药与1型糖尿病患者糖尿病肾病的进展有关,需要进一步明确成功治疗抑郁症是否可以降低其风险。
 
原始出处:
 
Aila J. Ahola,et al.Depression Is Associated With Progression of Diabetic Nephropathy in Type 1 Diabetes.Diabetes care.2020.https://care.diabetesjournals.org/content/early/2020/11/10/dc20-0493

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    2020-12-28 ms6000000854809298

    学习了

    0

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    2020-11-13 misszhang

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