Immunity :徐春亮等发现肠道菌群调控心理压力导致的血管炎症

2020-07-31 BioArt

精神压力是日常生活当中常见的心理活动,过度的精神压力会对人体健康产生有害的作用,和多种人体疾病的发病有正相关性,特别是心血管疾病。这些疾病通常和压力引起的炎症反应有紧密的关系。

精神压力(Psychological stress)是日常生活当中常见的心理活动,过度的精神压力会对人体健康产生有害的作用,和多种人体疾病的发病有正相关性,特别是血管疾病。这些疾病通常和压力引起的炎症反应有紧密的关系。当机体受到压力刺激时,大脑所产生的压力信号主要通过两种信号途径传递到其他器官:交感神经系统(sympathetic nervous system ,SNS)和下丘脑-垂体-肾上腺轴 (hypothalamic-pituitary-adrenal axis, HPA axis)。SNS被激活后可以分泌包括肾上腺素(adrenaline)和去甲肾上腺素(noradrenaline)等在内的激素,对机体功能进行调节。HPA axis被激活后,通过肾上腺皮质(adrenal cortex)分泌糖皮质激素发挥作用。然而,精神压力对血管疾病发病促进作用的机制尚不清楚。

2020年7月30日,爱因斯坦医学院 (Albert Einstein College of Medicine)Paul S. Frenette团队(第一作者为徐春亮博士)在Immunity杂志上发表了题为The gut microbiome regulates psychological stress-induced inflammation的文章。该研究表明,过度的精神压力会增加肠道通透性,进而导致肠道细菌分节丝状细菌(Segmented filamentous bacteria,SFB) 过度激活Th17 细胞,引起衰老中心粒细胞在血管内聚集并黏附到血管壁并结合红细胞形成细胞团,从而导致血管堵塞的发生。

在本研究中,徐春亮博士等人利用镰刀型贫血症(sickle cell disease, SCD)小鼠模型研究精神压力对血管堵塞的影响。血管堵塞现象(Vaso-occlusive episodes, VOE) 所导致的疼痛和器官损伤是SCD病人的主要临床表现。Paul Frenette教授实验室之前的研究表明,衰老中性粒细胞 (aged neutrophils) 介导了VOE的发生。在本研究中,徐春亮博士等人利用该疾病模型发现,束缚应激(restraint stress)和重复社交失败压力(repeated social defeat stress) 均可以促进VOE的发生,表明精神压力可以导致该血管堵塞异常的发作。机制研究发现,压力信号可以诱导衰老中性粒细胞在循环系统中聚集,导致VOE,并且这一过程依赖于肠道道菌群和Th17细胞。进一步研究发现,大脑产生的压力信号激活HPA通路,使后者分泌糖皮质激素从而增加了肠道壁的通透性,导致肠道细菌SFB过度激活Th17细胞,后者分泌的IL-17促进中性粒细胞的产生和在循环系统中的聚集和衰老。这项研究工作首次揭示了肠道菌群对精神压力所介导的血管疾病的调节作用,为该类疾病的治疗提供了新的思路。

第一作者徐春亮博士本科毕业于山东大学,之后在中国科学院上海生命科学院免疫学和干细胞专家时玉舫教授的指导下进行博士阶段的训练,主要从事间充质干细胞和免疫相互作用的研究。博士后训练阶段在骨髓干细胞权威Paul Frenette教授的指导下,进行造血干细胞微环境、肠道菌群、神经和炎症的相关工作。徐春亮博士之前工作以第一作者发表在Nature Medicine、Immunity、 Nature Communications、Journal of Experimental Medicine(已接收)、Blood和Oncogene等杂志,目前正在筹备建立自己的实验室,未来的实验室将以基础研究和转化研究并重,结合实验动物和临床样品,研究方向将集中于造血干细胞微环境、共生菌群、神经系统的相互影响以及血液疾病。

原始出处:

Chunliang Xu,Sung Kyun Lee,Dachuan Zhang,et al.The Gut Microbiome Regulates Psychological-Stress-Induced Inflammation.Immunity.Published:July 30, 2020DOI:https://doi.org/10.1016/j.immuni.2020.06.025

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2030407, encodeId=922d203040e13, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Nov 14 23:48:28 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263251, encodeId=fa8a1263251c6, content=<a href='/topic/show?id=581e8968859' target=_blank style='color:#2F92EE;'>#血管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89688, encryptionId=581e8968859, topicName=血管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392404, encodeId=adb013924040d, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479175, encodeId=002f14e91753c, content=<a href='/topic/show?id=5d67896914c' target=_blank style='color:#2F92EE;'>#血管炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89691, encryptionId=5d67896914c, topicName=血管炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92a47497019, createdName=ms6832696159214430, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630818, encodeId=d76d163081831, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2030407, encodeId=922d203040e13, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Nov 14 23:48:28 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263251, encodeId=fa8a1263251c6, content=<a href='/topic/show?id=581e8968859' target=_blank style='color:#2F92EE;'>#血管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89688, encryptionId=581e8968859, topicName=血管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392404, encodeId=adb013924040d, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479175, encodeId=002f14e91753c, content=<a href='/topic/show?id=5d67896914c' target=_blank style='color:#2F92EE;'>#血管炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89691, encryptionId=5d67896914c, topicName=血管炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92a47497019, createdName=ms6832696159214430, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630818, encodeId=d76d163081831, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2030407, encodeId=922d203040e13, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Nov 14 23:48:28 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263251, encodeId=fa8a1263251c6, content=<a href='/topic/show?id=581e8968859' target=_blank style='color:#2F92EE;'>#血管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89688, encryptionId=581e8968859, topicName=血管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392404, encodeId=adb013924040d, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479175, encodeId=002f14e91753c, content=<a href='/topic/show?id=5d67896914c' target=_blank style='color:#2F92EE;'>#血管炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89691, encryptionId=5d67896914c, topicName=血管炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92a47497019, createdName=ms6832696159214430, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630818, encodeId=d76d163081831, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2030407, encodeId=922d203040e13, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Nov 14 23:48:28 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263251, encodeId=fa8a1263251c6, content=<a href='/topic/show?id=581e8968859' target=_blank style='color:#2F92EE;'>#血管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89688, encryptionId=581e8968859, topicName=血管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392404, encodeId=adb013924040d, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479175, encodeId=002f14e91753c, content=<a href='/topic/show?id=5d67896914c' target=_blank style='color:#2F92EE;'>#血管炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89691, encryptionId=5d67896914c, topicName=血管炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92a47497019, createdName=ms6832696159214430, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630818, encodeId=d76d163081831, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2030407, encodeId=922d203040e13, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Nov 14 23:48:28 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263251, encodeId=fa8a1263251c6, content=<a href='/topic/show?id=581e8968859' target=_blank style='color:#2F92EE;'>#血管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89688, encryptionId=581e8968859, topicName=血管炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=909c71, createdName=shijzhiewnjhch, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392404, encodeId=adb013924040d, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479175, encodeId=002f14e91753c, content=<a href='/topic/show?id=5d67896914c' target=_blank style='color:#2F92EE;'>#血管炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89691, encryptionId=5d67896914c, topicName=血管炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92a47497019, createdName=ms6832696159214430, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630818, encodeId=d76d163081831, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Sun Aug 02 02:48:28 CST 2020, time=2020-08-02, status=1, ipAttribution=)]

相关资讯

Eur J Nutr:母羊酸奶和牛奶酸奶对临界-高血浆胆固醇患者炎症标志物和肠道菌群的影响

与牛乳酸奶相比,母羊乳酸奶含有更丰富的蛋白质、矿物质和中短链脂肪酸。本研究旨在评估母羊乳酸奶(CW,3.0%脂肪)、半脱脂(ES,2.8%脂肪)和全牛乳酸奶(EW,5.8%脂肪)对边缘高血浆胆固醇受试

Nature:微生物群通过肠脑回路调控交感神经元

肠道和大脑之间的连接可以监测肠道组织及其微生物,以及饮食内容,调节生理肠道功能,如营养物质的吸收和运动,和脑控制的进食行为。

Am J Clin Nutr:酸奶可改善非酒精性脂肪肝病和代谢综合症女性的胰岛素抵抗和肝脂肪状况

由于食用常规酸奶对健康人群具有有益的影响,胰岛素抵抗(IR)是非酒精性脂肪肝疾病(NAFLD)和代谢综合征(MetS)的相互发病机制,因此我们假设酸奶可以改善NAFLD和MetS患者的IR。

CELL:肠道菌群通过胆酸-I型IFN信号轴限制病毒传播

基孔肯雅病毒(CHIKV)是一种新出现的阿尔法病毒,已经感染了数百万人。然而,至今为止,我们对于调控疾病结果的因素仍然知之甚少。

JAHA:肠道菌群与血压之间的关联

尽管总体肠道微生物分类组成与BP之间的关联较弱,但高血压患者表现出几个菌属的改变。该研究证明了某些乳杆菌物种与钠摄入量和血压之间存在强烈的负相关性,强调了进行实验性研究的必要性。

Diabetes Care:红细胞n-6多不饱和脂肪酸、肠道菌群和2型糖尿病发病率

红细胞GLA的相对浓度与2型糖尿病的发病呈正相关,与肠道微生物群也呈正相关。这些结果表明,肠道菌群可能在连接n-6 PUFA代谢和2型糖尿病病因方面起重要作用。