Allergol Immunopathol (Madr):过敏性鼻炎严重度与中性粒细胞/淋巴细胞、嗜酸性粒细胞/中性粒细胞和嗜酸性粒细胞/淋巴细胞比率的关系

2021-09-15 AlexYang MedSci原创

调查了中性粒细胞与淋巴细胞比率(NLR)、嗜酸粒细胞与中性粒细胞比率(ENR)和嗜酸粒细胞与淋巴细胞比率(ELR)这三个炎症参数是否能够区分间歇过敏性鼻炎和持续过敏性鼻炎。

过敏性鼻炎(AR)患者会产生睡眠障碍、情绪问题和社交障碍,工作、学习和生活质量都会受到影响。AR是一种鼻粘膜慢性炎症疾病。T-helper 2淋巴细胞、中性粒细胞和嗜酸性粒细胞在接触过敏原后的后期免疫反应中,发挥了积极的作用。

近期,来自土耳其的研究人员在《Allergol Immunopathol (Madr)》杂志上发表文章,调查了中性粒细胞与淋巴细胞比率(NLR)、嗜酸粒细胞与中性粒细胞比率(ENR)和嗜酸粒细胞与淋巴细胞比率(ELR)这三个炎症参数是否能够区分间歇过敏性鼻炎和持续过敏性鼻炎

该研究是一项双中心的回顾性研究。根据《过敏性鼻炎及其对哮喘的影响》指南,那些诊断为AR的患者参与研究,排除了患有活动性感染的患者。对照组为健康参与者。研究人员使用患者全血细胞计数结果,计算了NLR、ENR和ELR,并对所有研究变量进行了描述性统计分析。

研究总共包括205名AR患者和49名健康对照。与健康对照组相比,AR患者的绝对嗜酸细胞数、ENR和ELR水平明显较高,NLR水平明显较低(P<0.05)。总共有160名(78%)持续性AR患者的绝对嗜酸性粒细胞数、ENR和ELR水平显著高于间歇性AR患者,而NLR水平则明显低于间歇性AR患者(P<0.05)。

ROC分析确定ELR、NLR和ENR在持续过敏性鼻炎中的诊断效果

目前,对AR严重程度的分类是基于患者的病历。而该研究表明,持久性AR患者的血清嗜酸性粒细胞水平可作为评估疾病严重程度的参数。他们也预计,上述结论将会得到更多研究的支持。

原始出处:

Aydin Kant , Kadriye Terzioğlu. Association of severity of allergic rhinitis with neutrophil-to-lymphocyte, eosinophil-to-neutrophil, and eosinophil-to-lymphocyte ratios in adults. Allergol Immunopathol (Madr). Sep 2021

 

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    2021-12-24 ms3000001144576841

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GetPortalCommentsPageByObjectIdResponse(id=1051933, encodeId=232a1051933c0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659f3850578, createdName=137756abm51暂无昵称, createdTime=Thu Sep 16 12:33:39 CST 2021, time=2021-09-16, status=1, ipAttribution=)]
    2022-07-29 yb6560
  5. 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    2021-09-21 ms8000000911689223

    学到了

    0

  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=2047446, encodeId=17d3204e446f6, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Oct 16 13:26:41 CST 2021, time=2021-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634138, encodeId=c2da163413863, content=<a href='/topic/show?id=0e84211e53b' target=_blank style='color:#2F92EE;'>#严重度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21175, encryptionId=0e84211e53b, topicName=严重度)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  9. 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    2021-09-17 膀胱癌
  10. 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    2021-09-16 137756abm51暂无昵称

    学习了

    0

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