Heart:中段心房钠尿肽可预测肥厚型心肌病患者结局

2020-01-13 不详 MedSci原创

N末端钠尿肽(NT-proBNP)可以预测肥厚型心肌病(HCM)患者的死亡率和心力衰竭的发生。中段心钠尿肽(MR-proANP)是一种心房钠尿肽的稳定的副产物,本研究的目的旨在比较和评估NT-proBNP和MR-proANP在预测HCM结局中的作用。本研究纳入分析了357名HCM患者,平均年龄为52岁,NT-proBNP和MR-proANP均与年龄、体重、纽约心功能评级(NYHA)、左室射血分数(

N末端钠尿肽(NT-proBNP)可以预测肥厚型心肌病(HCM)患者的死亡率和心力衰竭的发生。中段心钠尿肽(MR-proANP)是一种心房钠尿肽的稳定的副产物,本研究的目的旨在比较和评估NT-proBNP和MR-proANP在预测HCM结局中的作用。

本研究纳入分析了357名HCM患者,平均年龄为52岁,NT-proBNP和MR-proANP均与年龄、体重、纽约心功能评级(NYHA)、左室射血分数(LVEF)、左室壁厚度和左房大小呈独立相关性。经过平均23个月的随访,有32名患者出现了主要终点事件(6名死亡、8名接受心脏移植、1名植入左室辅助装置、17名心衰住院),NT-proBNP和MR-proANP均与主要终点事件呈强相关性。在多元逐步回归分析中,最佳的预测模型包括NYHA1-2和3-4、LVEF和MR-proANP。

研究结果显示,在肥厚型心肌病患者中,MR-proANP可作为预测患者结局的有效标志物。

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    2020-01-15 zhaojie88
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    2020-01-15 slcumt
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    2020-01-15 sodoo

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