JACC:慢性主动脉瓣反流患者的预后研究

2019-04-18 不详 MedSci原创

目前,对明显主动脉瓣反流(AR)患者的特征和预后尚不清楚。本研究的目的旨在评估主动脉瓣修复或置换术(AVR)对AR患者的益处以及左室大小对AR患者预后的预测价值。本研究纳入了748例无心梗和心脏手术史的中重度慢性AR患者(平均年龄58±17岁,男性占82%),其中52%患者接受了治疗,48%患者接受了AVR治疗。在361名接受AVR治疗患者中,334名符合指南标准。经过平均4.9年时间的随访,12

目前,对明显主动脉瓣反流(AR)患者的特征和预后尚不清楚。本研究的目的旨在评估主动脉瓣修复或置换术(AVR)对AR患者的益处以及左室大小对AR患者预后的预测价值。

本研究纳入了748例无心梗和心脏手术史的中重度慢性AR患者(平均年龄58±17岁,男性占82%),其中52%患者接受了治疗,48%患者接受了AVR治疗。在361名接受AVR治疗患者中,334名符合指南标准。经过平均4.9年时间的随访,125名患者死亡,年龄、并发症、基础疾病和更高的左室收缩末期指数(LVESDi)与全因死亡率相关(p ≤ 0.01)。与 LVESDi <20 mm/m2的患者相比, LVESDi 在20-25 mm/m2间和≥25 mm/m2患者的死亡风险更高。另外,AVR与更高的生存率相关(p < 0.0001)。

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    2019-11-18 hbwxf
  3. 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    2019-06-18 wy820308045

    谢谢分享

    0

  4. 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createdBy=55ce62, createdName=hbwxf, createdTime=Mon Nov 18 15:29:00 CST 2019, time=2019-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367953, encodeId=604736e95386, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=305e1677999, createdName=wy820308045, createdTime=Tue Jun 18 12:17:23 CST 2019, time=2019-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366269, encodeId=ca04366269ea, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed May 15 23:56:16 CST 2019, time=2019-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366227, encodeId=f62836622e7e, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue May 14 23:48:52 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365585, encodeId=21853655857c, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed May 01 20:46:58 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326182, encodeId=2c6f132618242, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332640, encodeId=11321332640ba, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415506, encodeId=6d4c1415506a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571641, encodeId=a09615e16410e, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-05-15 清风拂面

    谢谢分享学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1634741, encodeId=38ab1634e4174, content=<a href='/topic/show?id=d76223185de' target=_blank style='color:#2F92EE;'>#主动脉瓣反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23185, encryptionId=d76223185de, topicName=主动脉瓣反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d7a22278874, createdName=ms2999106592497887, createdTime=Sat Mar 21 09:29:00 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854361, encodeId=79bd185436171, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Nov 18 15:29:00 CST 2019, time=2019-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367953, encodeId=604736e95386, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=305e1677999, createdName=wy820308045, createdTime=Tue Jun 18 12:17:23 CST 2019, time=2019-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366269, encodeId=ca04366269ea, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed May 01 20:46:58 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326182, encodeId=2c6f132618242, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332640, encodeId=11321332640ba, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415506, encodeId=6d4c1415506a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571641, encodeId=a09615e16410e, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-05-14 清风拂面

    谢谢分享学习

    0

  6. 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style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415506, encodeId=6d4c1415506a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571641, encodeId=a09615e16410e, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Sat Apr 20 04:29:00 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-05-01 清风拂面

    谢谢分享学习

    0

  7. 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    2019-04-20 feifers

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梅斯医研社,中国医学精英的内容头等舱。

JAHA:他汀类药物与糖尿病发生呈时间剂量相关性

他汀类药物被越来越广泛地用于一级预防,但是他汀药物与糖尿病发生的相关性问题不容忽视。本研究纳入了2005-2012年年龄≥40岁的复合他汀类药物适应症的高血脂患者,主要终点事件是接受药物治疗后的新发糖尿病。在2162119名复合他汀药物治疗适应症的高血脂患者中,有29.5%患者曾经使用过他汀类药物,经过平均3.9年时间的随访,相比于从没使用过他汀药物患者,使用过他汀药物患者的糖尿病风险明显更高(H

Circulation:2型糖尿病的诊断年龄与心血管和死亡风险的关联

由此可见,诊断T2DM的年龄对于生存和心血管风险具有重要的预后价值,对于确定临床决策和指导性治疗的危险因素干预的时间和强度具有重要意义。这些观察结局扩大了对年轻个体预防/延迟T2DM发作的支持力度。

JACC:标准化治疗可改善心源性休克预后

心源性休克(CS)是一种多因素的血流动力学复杂的综合征,死亡率高。尽管在再灌注和机械循环支持方面取得了进展,但CS的治疗方法仍然存在很大的差异,且效果不佳。本研究的目的旨在评估以团队为基础的标准化方法是否可以改善CS的预后。本研究纳入分析了204名CS患者,并对患者的CS病因、人口统计学特征、右心导管插入术、机械循环支持使用和生存率进行了统计,在基线水平和CS诊断后24小时测量了患者的心输出功率(

JACC:经导管主动脉瓣置换术后感染性心内膜炎的远期发生率研究

接受外科主动脉瓣置换术(SAVR)后的患者发生感染性心内膜炎(IE)的风险会更高,然而经导管主动脉瓣置换术(TAVR)后的IE发生风险尚不清楚。本研究纳入分析了丹麦国家数据库中的2632名接受TAVR治疗和3777名接受SAVR治疗的无IE病史的患者,经过平均3.6年时间的随访,4.4%的TAVR组患者和4.9%的SAVR组患者出现感染性心内膜炎,两组患者从手术到IE住院之间的平均时间间隔分别为3