颈前路后纵韧带骨化切除术脑脊液漏发生率高

2012-11-16 Jane摘编 医学论坛网

  上海长征医院脊柱外科的一项研究表明,颈椎后纵韧带骨化症(OPLL)患者行颈前路手术术中易发生硬脊膜损伤,术中一期修复极为困难,术后脑脊液漏发生率高,应采取综合措施处理,以获痊愈。该论文发表在2012年第10期《中国脊柱脊椎杂志》。   该研究选取2008年1月~2012年1月采用颈前路后纵韧带骨化切除术治疗颈椎OPLL患者126例,男89例,女37例;年龄平均61岁;病程平均4.2年。骨化物

  上海长征医院脊柱外科的一项研究表明,颈椎后纵韧带骨化症(OPLL)患者行颈前路手术术中易发生硬脊膜损伤,术中一期修复极为困难,术后脑脊液漏发生率高,应采取综合措施处理,以获痊愈。该论文发表在2012年第10期《中国脊柱脊椎杂志》。

  该研究选取2008年1月~2012年1月采用颈前路后纵韧带骨化切除术治疗颈椎OPLL患者126例,男89例,女37例;年龄平均61岁;病程平均4.2年。骨化物在矢状面上范围涉及1~3个椎体。术中发现11例患者合并硬脊膜骨化,其中7例术中发生硬脊膜破损(4例为硬脊膜撕裂,3例形成硬脊膜缺损);115例未合并硬脊膜骨化患者中,4例发生硬脊膜撕裂。术中均采用明胶海绵覆盖及生物蛋白胶封堵,术后采用常压引流、卧床休息、预防感染及营养支持等方法综合处理,观察患者脑脊液漏情况及转归。

  结果是,11例术中硬脊膜破损的患者术后均发生脑脊液漏,脑脊液漏发生率为8.7%(11/126),其中合并硬脊膜骨化患者术后脑脊液漏发生率为63.6%(7/11),未合并硬脊膜骨化患者术后脑脊液漏发生率为0.03%(4/115),两组比较差异有统计学意义(P<0.001)。经综合处理后,3例于术后3~5d内痊愈;8例患者切口愈合拔管后形成间隙性脑脊液囊肿,经反复穿刺抽吸、颈部环形加压包扎治疗,均于术后14~30d内痊愈,其中1例合并颅内感染,经腰大池置管持续引流加鞘内注射抗生素治疗痊愈。11例患者均获随访,随访时间平均12.8个月,无神经症状加重及持续性头痛等后遗症发生,术后平均神经功能改善率为51.2%。



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