NAT COMMUN:易流产的胚胎发育轨迹有何不同?

2020-08-11 MedSci原创 MedSci原创

人类的生育率非常低。目前认为,非整倍体是人类生殖的主要限制之一,约占早孕损失的50%。此外,非整倍体率在体外受精人类胚胎中是非常高的,根据植入前的非整倍体基因检测(PGT-A).

人类的生育率非常低。目前认为,非整倍体是人类生殖的主要限制之一,约占早孕损失的50%。此外,非整倍体率在体外受精人类胚胎中是非常高的,根据植入前的非整倍体基因检测(PGT-A),高达50%的胚胎被诊断为非整倍体。非整倍体可能导致植入失败、流产以及先天性缺陷。

然而,至今为止,特定非整倍体是如何发育的仍未被探索。

最近,研究人员在Nature Communications上发文,报导了在其最近建立的培养平台上,携带常见的非整倍体的人类胚胎植入后的发展程度。

研究人员表明,虽然15三体综合征和21三体综合征胚胎发育类似于整倍体的胚胎,但是21单体胚胎表现出高发育停滞率,16三体胚胎表现出形成胎盘组织的滋养细胞的低增殖。

使用人类滋养层干细胞,研究人员表明,这种表型可以从机制上归因于细胞粘附蛋白E-CADHERIN水平的增加,从而导致过早分化和细胞周期停止。

此外,研究人员还确定了三例通过植入前基因检测诊断为完全非整倍体的胚胎中的马赛克现象。

该结果首次详细分析了非整倍体人类胚胎的植入后发育情况。

原始出处:

Marta N. Shahbazi et al. Developmental potential of aneuploid human embryos cultured beyond implantation, Nature Communications (2020). 

 

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    2021-01-05 liuli5079
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    2020-08-13 ailian1202
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    2020-08-13 neurowu

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