Eur Respir J:空气污染波动对支气管扩张肺部恶化的影响

2018-07-28 xing.T MedSci原创

总之,空气污染波动与支气管扩张的恶化风险增加有关。

在支气管扩张中,病情恶化认为是由感染因素引发的,但通常不能确定病原体。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员假设急性空气污染暴露可能与支气管扩张恶化有关。

在观察性记录连锁研究中,研究人员将病例交叉设计与分布式滞后模型相结合。研究人员从英国邓迪的Ninewells医院支气管扩张专科招募患者;通过高分辨率计算机断层扫描诊断后,共招募了432名临床证实的支气管扩张患者。

排除没有空气污染数据的天数后,对于50%临界值空气动力学直径为10μm(PM10)颗粒的最终模型是基于430名患者的6741次病情恶化,对于二氧化氮(NO2)的最终模型是基于426名患者的6248次病情恶化。对于PM10和NO2每增加10μg/m3,当天发生病情恶化的风险分别显著增加4.5%(95%CI为0.9-8.3)和3.2%(95%CI为0.7-5.8)。PM10的空气污染物浓度增加10μg/m3时,恶化风险总体(滞后0到4)增加为11.2%(95%CI为6.0-16.8),同时对于NO2为4.7%(95%CI为0.1-9.5)。亚组分析显示室外空气污染暴露预计最高的春季(PM10为1.198(95%CI为1.102-1.303),NO2为1.146(95%CI为1.035-1.268))和夏季(PM10为2.142(95%CI为1.785-2.570),NO2为1.352(95%CI为1.140-1.602))相对风险较高。

总之,空气污染波动与支气管扩张的恶化风险增加有关。

原始出处:


Pieter C. Goeminne,et al. The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis. Eur Respir J. 2018. http://erj.ersjournals.com/content/52/1/1702557

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    2019-01-01 lsj637
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    2018-09-02 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2018-08-04 liumin1987

    空气污染和很多肺部疾病有关。

    0

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