Clin Oral Investig:0.8%透明质酸作为翻瓣清创术的辅助手段治疗牙周炎骨内缺损的疗效

2021-09-20 MedSci原创 MedSci原创

慢性牙周炎是一种以结缔组织破坏和支持性牙槽骨丧失为特征的炎症性疾病,最终导致牙齿脱落。近日,Clin Oral Investig的一项随机试验评估和比较了0.8%透明质酸(HA)凝胶作为翻瓣清创术(O

慢性牙周炎是一种以结缔组织破坏和支持性牙槽骨丧失为特征的炎症性疾病,最终导致牙齿脱落。近日,Clin Oral Investig的一项随机试验评估和比较了0.8%透明质酸(HA)凝胶作为翻瓣清创术(OFD)的辅助手段与单独翻瓣清创术(OFD)在治疗牙周骨内缺损方面的临床和影像学疗效。

这项随机、对照、分口的临床试验共纳入了20名慢性牙周炎(II或III期(A至B级))患者,至少有两个对侧牙槽骨内缺损。将40个双侧骨内缺损(每组20个)随机分为试验组(0.8%HA凝胶+OFD)和对照组(OFD+安慰剂)。基线、6个月和12个月评估临床指数:菌斑指数(PI)、牙龈指数(GI)、探诊深度(PD)、临床附着水平(CAL)和牙龈退缩(GR)。使用锥形束计算机断层扫描(CBCT),在基线和12个月内评估放射学参数:骨缺损填充(DF),牙槽嵴变化(ACC),以及缺损填充(DR)。CAL作为主要结果变量。

 

结果显示,12个月后,与对照组相比,试验组的CAL增加(5.1±1.2 VS. 4.05±1.19mm)和骨缺损填充(DF)(5.67±2.01 VS. 4.49±1.78mm)明显增加。与对照组相比,试验组的平均PD减少(5.3±1.2 VS. 4.35±0.81mm),在12个月期间有统计学意义。12个月后,对照组与试验组相比,GR明显增加(1.2±0.76对0.7±0.73mm)。

综上所述,与单独的翻瓣清创术相比,透明质酸凝胶联合翻瓣清创术可增强骨缺损再生的临床和影像学效果。

 

原始出处:

 

Alefiya S Mamajiwala, et al., Clinical and radiographic evaluation of 0.8% hyaluronic acid as an adjunct to open flap debridement in the treatment of periodontal intrabony defects: randomized controlled clinical trial. Clin Oral Investig. 2021 Sep;25(9):5257-5271. doi: 10.1007/s00784-021-03834-7.

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    2021-10-01 小几洁
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    2022-07-11 lingaifan
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    2021-09-21 查查佳佳

    DJ屋企咯对惹二金融街6vuv 特他设计思路

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