JGH:高级别浅表非壶腹十二指肠上皮肿瘤的独立预测因子是肿瘤位置和大小

2021-06-15 MedSci原创 MedSci原创

随着内窥镜技术和诊断的不断进展,研究人员已经意识到浅表性非壶腹十二指肠上皮肿瘤 (SNADET) 的发病率一直在增加。

      随着内窥镜技术和诊断的不断进展,研究人员已经意识到浅表性非壶腹十二指肠上皮肿瘤 (SNADET) 的发病率一直在增加。然而,具有恶性潜能的 SNADET 的临床特征仍不清楚。因此,本研究的目的是阐明高级别 SNADET 的临床特征。

 

      研究人员从内窥镜和病理数据库中确定了 2013 年 1 月至 2019 年 4 月期间内镜或手术切除的 328 个 SNADET病例。然后比较了这些患者的黏膜低级别肿瘤 ( n  = 154) 和黏膜高级别肿瘤/黏膜下癌 (HGN/SMC,n  = 174) 的临床特征。

 

      研究结果分析显示:在单变量分析中,肿瘤大小、壶腹前肿瘤位置、红色和粗糙/结节表面与 HGN/SMC 显着相关。在多变量分析中,肿瘤大小(≥10 毫米)(OR:4.5,95% CI:2.6-7.7,P< 0.001)和壶腹前肿瘤位置(OR : 2.1, 95%CI: 1.3–3.5, P= 0.004) 是HGN /SMC 的独立预测因子。组织学表型分析显示,胃型肿瘤(21/23 个病灶,91%)中 HGN/SMC 的肿瘤比例远高于肠型肿瘤(150/302 个病灶,50%)(P< 0.001)并且所有胃型肿瘤都位于壶腹前部分。

 

       本项研究证实壶腹前位置和大肿瘤大小是 HGN/SMC型的 SNADET 的独立预测因素。壶腹前肿瘤位置与胃组织学表型显着相关。

 

 

原始出处:

Katsunori Matsueda. Et al. Pre-ampullary location and size ≥10 mm are independent predictors for high-grade superficial non-ampullary duodenal epithelial tumors. Journal of Gastroenterology and Hepatology.2021.

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