JCEM:牙周炎与糖尿病风险之间的相关性

2021-05-13 MedSci原创 MedSci原创

牙周病与糖尿病发病率相关,尤其是在非肥胖参与者中。牙医应该意识到牙周病与糖尿病发病率之间的相关性,但这种关联可能在BMI水平较高的患者中有所改变。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在明确牙周病是否与不同体重水平(BMI)个体的糖尿病发病率之间呈正相关,并验证体重指数是否可以改变牙周病导致糖尿病风险的假设。

研究人员纳入了社区动脉粥样硬化风险(ARIC)研究(1996-1998)中5569名无糖尿病参与者,并跟踪随访至2018年。牙周病状态以牙周轮廓分类(PPC)-分期进行归类,糖尿病是基于参与者报告的临床诊断为基础。研究人员对每个PPC阶段使用竞争风险模型来估计糖尿病的风险比(HR),并评估了牙周病和BMI(作为一个连续变量)对糖尿病风险的相互作用。

在平均19.4年的随访期间,共发生了1348例糖尿病病例和1529例死亡病例。与“健康/附带疾病”阶段相比,PPC为“严重牙周病”或“严重牙齿脱落”阶段以及BMI较低的参与者中糖尿病风险增加,调整人口统计学指标、吸烟、教育和生物学变量后,将死亡作为竞争风险来解释时,其HR分别为1.76 (95%CI为1.10-2.80)和2.11 (95%CI为1.46-3.04)。PPC分期与BMI之间的交互作用显著(p=0.01)。

牙周炎与糖尿病

BMI高于31kg/m2时,PPC分期与糖尿病发生率无显著相关性。

由此可见,牙周病与糖尿病发病率相关,尤其是在非肥胖参与者中。牙医应该意识到牙周病与糖尿病发病率之间的相关性,但这种关联可能在BMI水平较高的患者中有所改变

原始出处:

Shaoping Zhang.et al.Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-modified Association.JCEM.2021.https://doi.org/10.1210/clinem/dgab337

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    2021-12-05 achengzhao
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    2021-10-06 smallant2015
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    2021-05-14 yoyolx

    肥胖增加牙周病发生率

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    2021-05-14 misszhang

    谢谢MedSci提供最新的资讯

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