Chest:抗纤维蛋白溶解剂治疗囊性纤维化成人咯血

2019-03-02 xing.T 网络

由此可见,利用全身抗纤维蛋白溶解疗法治疗CF患者咯血的途径与住院率降低有关,未观察到严重不良事件。需要进一步的研究来明确CF患者全身抗纤维蛋白溶解的益处。

咯血是囊性纤维化(CF)患者发病率和死亡率的主要原因。抗纤维蛋白溶解剂已经在广泛的出血性疾病和病例中证明有效。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员旨在评估使用抗纤维蛋白溶解剂来控制CF患者咯血的疗效。研究人员为其住院和门诊使用开发了临床治疗途径,并报告了实施前后出血的入院率。

研究人员根据治疗途径,对在54个月内用全身抗纤维蛋白溶解剂治疗的所有成年CF患者进行了分析。收集的数据包括人口统计学指标、基线CF相关特征以及出血和治疗参数。通过比较治疗途径登记前后的年化咯血入院率来评估该治疗途径的有效性。

在总共纳入的21名成年CF患者中分析了用抗纤维蛋白溶解剂治疗的72次不同咯血发作。治疗的三分之二发作涉及中度或大量咯血。出血停止的中位数为两天。门诊治疗与治疗途径注册后年度咯血入院率降低50%相关(每年入院2.44 vs. 1.23,P=0.0024),这与治疗中的其他变化无关。抗纤维蛋白溶解疗法耐受性良好。在同一血管中先前发生血栓形成的患者中观察到中心导管相关的上肢深静脉血栓形成。

由此可见,利用全身抗纤维蛋白溶解疗法治疗CF患者咯血的途径与住院率降低有关,未观察到严重不良事件。需要进一步的研究来明确CF患者全身抗纤维蛋白溶解的益处。

原始出处:


Hanny Al-Samkari, et al.Antifibrinolytic Agents for Hemoptysis Management in Adults with Cystic Fibrosis.chest.2019.https://doi.org/10.1016/j.chest.2019.02.010

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    2020-01-10 仁医06
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    2019-11-01 wolongzxh
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    2019-07-02 zhaojie88
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    2019-03-04 feather80