JACC:血清胆固醇流出量与心梗患者死亡率呈负相关性

2018-12-24 MedSci MedSci原创

血浆胆固醇流出量是一个独立于高密度脂蛋白(HDL)胆固醇的与动脉粥样硬化相关的生物标志物,本研究的目的旨在评估血浆胆固醇流出量在预测因急性心梗住院患者死亡率方面的作用。本研究对1609名因急性心梗住院的患者进行了血浆胆固醇流出量、胆固醇酯转移蛋白(CETP)活性、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯水平的检测,主要终点事件是全因死亡率。经过平均1.9年时间的随访,发现在一个包

血浆胆固醇流出量是一个独立于高密度脂蛋白(HDL)胆固醇的与动脉粥样硬化相关的生物标志物,本研究的目的旨在评估血浆胆固醇流出量在预测因急性心梗住院患者死亡率方面的作用。

本研究对1609名因急性心梗住院的患者进行了血浆胆固醇流出量、胆固醇酯转移蛋白(CETP)活性、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯水平的检测,主要终点事件是全因死亡率。经过平均1.9年时间的随访,发现在一个包含年龄、性别和传统血管危险因素的模型中,血浆胆固醇流出量是生存率的强预测因子,与血浆胆固醇流出量降低的患者相比,血浆胆固醇流出量升高的患者的死亡率明显更低(HR:0.54 [0.32 - 0.89]; p?=?0.0165)。

研究结果显示,血浆胆固醇流出量在急性心梗患者中与死亡率呈明显负相关性,且独立于HDL胆固醇和传统血管危险因素。

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    2019-03-22 hbwxf
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    2018-12-26 hmwwww

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