CAR-T细胞免疫疗法(idecabtagene vicleucel)治疗多发性骨髓瘤

2020-04-01 Allan MedSci原创

百时美施贵宝(Bristol Myers Squibb)和蓝鸟生物本周二(2020年3月31日)报道,已向FDA提交了上市申请。

百时美施贵宝(Bristol Myers Squibb)和蓝鸟生物本周二(2020年3月31日)报道,已向FDA提交了idecabtagene vicleucel(ide-cel)治疗复发难治性多发性骨髓瘤的上市申请,这些患者至少接受过三种疗法,包括免疫调节剂、蛋白酶体抑制剂和抗CD38抗体。

idecabtagene vicleucel(ide-cel)是一款靶向BCMA的CAR-T细胞免疫疗法。TNFRSF17是TNF受体家族的一员,被称为肿瘤坏死因子受体超家族成员17,又名B细胞成熟抗原(BCMA)或CD269,它是由TNFRSF17基因编码的蛋白质。该受体表达于B淋巴细胞及浆细胞表面,是一种B淋巴细胞成熟的标志蛋白。

II期KarMMa试验招募了140例接受过至少三种先前治疗方案的成年患者,其中128名接受了ide-cel治疗。12个月报告的主要数据显示,该研究达到了总体缓解率(ORR)的主要终点,以及完全缓解率(CR)的次要终点。

 

原始出处:

https://www.firstwordpharma.com/node/1711850

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    2020-09-23 jml2009
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    2020-10-10 docwu2019
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content=<a href='/topic/show?id=e5d5e779600' target=_blank style='color:#2F92EE;'>#细胞免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77796, encryptionId=e5d5e779600, topicName=细胞免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b707274309, createdName=dzx0922891, createdTime=Fri Apr 03 12:54:48 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629096, encodeId=7adb162909688, content=<a href='/topic/show?id=c92340e325' target=_blank style='color:#2F92EE;'>#CAR-T细胞免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4073, encryptionId=c92340e325, topicName=CAR-T细胞免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdd121300695, createdName=andy2094, createdTime=Fri Apr 03 12:54:48 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381238, encodeId=251f38123884, content=學習了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Apr 02 00:19:14 CST 2020, time=2020-04-02, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1890106, encodeId=8c35189010629, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Wed Sep 23 16:54:48 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943637, encodeId=9bbc194363e6e, content=<a href='/topic/show?id=42b918013fe' target=_blank style='color:#2F92EE;'>#T细胞免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18013, encryptionId=42b918013fe, topicName=T细胞免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68f2317, 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content=<a href='/topic/show?id=e5d5e779600' target=_blank style='color:#2F92EE;'>#细胞免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77796, encryptionId=e5d5e779600, topicName=细胞免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b707274309, createdName=dzx0922891, createdTime=Fri Apr 03 12:54:48 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629096, encodeId=7adb162909688, content=<a href='/topic/show?id=c92340e325' target=_blank style='color:#2F92EE;'>#CAR-T细胞免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4073, encryptionId=c92340e325, topicName=CAR-T细胞免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdd121300695, createdName=andy2094, createdTime=Fri Apr 03 12:54:48 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381238, encodeId=251f38123884, content=學習了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Apr 02 00:19:14 CST 2020, time=2020-04-02, status=1, ipAttribution=)]
    2020-06-02 仁者大医
  6. 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content=<a href='/topic/show?id=e5d5e779600' target=_blank style='color:#2F92EE;'>#细胞免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77796, encryptionId=e5d5e779600, topicName=细胞免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b707274309, createdName=dzx0922891, createdTime=Fri Apr 03 12:54:48 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629096, encodeId=7adb162909688, content=<a href='/topic/show?id=c92340e325' target=_blank style='color:#2F92EE;'>#CAR-T细胞免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4073, encryptionId=c92340e325, topicName=CAR-T细胞免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdd121300695, createdName=andy2094, createdTime=Fri Apr 03 12:54:48 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381238, encodeId=251f38123884, content=學習了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Apr 02 00:19:14 CST 2020, time=2020-04-02, status=1, ipAttribution=)]
    2021-01-12 cy0324
  7. 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    2020-04-02 飛歌

    學習了很有用不錯

    0

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Blood:14-3-3蛋白调节MM对蛋白酶体抑制剂的敏感性

14-3-3ε通过mTORC1途径调控多发性骨髓瘤细胞的蛋白负荷/容量平衡。14-3-3ε的表达水平可预测多发性骨髓瘤对蛋白酶体抑制剂的敏感性。

Blood:Daratumumab单药疗法用于淀粉样变患者的疗效和安全性

中心点:Daratumumab单药治疗在以前治疗的AL患者中引起了深刻和快速的血液反应,具有良好的安全性。非常好的部分缓解或更好的患者采用Daratumumab单药治疗6个月可获得持久的缓解。摘要:Daratumumab(达雷木单抗)是一种靶向CD38的单克隆抗体,CD38是一种在多发性骨髓瘤和轻链淀粉样变患者的浆细胞中普遍表达的抗原。Roussel等研究人员开展了一个前瞻性的多中心的2期试验,研

Blood Cancer Journal:一种检测多发性骨髓瘤多种耐药性的新技术

多发性骨髓瘤(MM)是一种无法治愈的终末分化的骨髓浆细胞瘤,作为全球第二大血液系统恶性肿瘤,其5年生存率仅为43%。自1990年以来,它的发病率增加了126%,仅在2018年里就报道了159 985例

FDA批准赛诺菲靶向CD38的单抗Sarclisa,用于治疗复发或难治的多发性骨髓瘤

美国食品和药物管理局已批准赛诺菲的Sarclisa(isatuximab-irfc)用于治疗多发性骨髓瘤。该药物靶向骨髓瘤细胞表面的CD38蛋白发挥作用,这是继强生公司的Darzalex(daratumumab)获批之后第二个靶向CD38蛋白的药物。

拓展阅读

Nature:淋巴瘤中CARD11-PIK3R3突变,让CAR-T细胞抗癌能力提高百倍

存在于淋巴瘤中的基因突变——CARD11-PIK3R3,让CAR-T细胞对实肿瘤的杀伤作用提高百倍。这一研究结果也提示我们,合理利用自然发生的基因突变可能是改良T细胞免疫疗法的新方向。

突破实体瘤:基于干细胞样T细胞的CAR-T细胞,显示出实体瘤治疗潜力

该研究开发了一种基于干细胞样T细胞(TSTEM)的新型CAR-T细胞疗法,相较于基于传统T细胞的CAR-T细胞,TSTEM CAR-T细胞扩增能力更强,并在临床前研究中证明其对实体瘤有效。

体内诱导CAR-T细胞:有望突破当前CAR-T细胞治疗的障碍

该论文综述了CAR结构、基因编辑工具和基因递送技术在免疫治疗中的应用,以及免疫细胞治疗的未来趋势,有助于设计和开发新的体内原位诱导CAR-T细胞。

值得关注:35家免疫细胞治疗企业和技术管线

一文梳理CAR-T疗法!建议收藏!

21节!CAR-T细胞治疗最新进展课程!

21节!CAR-T细胞治疗最新进展课程!涉及到CAR-T细胞治疗的技术,血液肿瘤中的应用,新型CAR细胞治疗技术,以及CAR细胞治疗在实体瘤中的探索。

NEJM:BCMA CAR-T细胞用于复发难治性多发性骨髓瘤效果显著(KarMMa-3研究)

多发性骨髓瘤是第二大血液恶性肿瘤,当前主要的治疗药物包括蛋白酶体抑制剂(PI)、免疫调节剂(IMiDs)和单克隆抗体(mAb),虽然近二十年中多发性骨髓瘤的治疗得到了显著改善,但它仍是一个无法治愈的疾