AJG:炎症性肠病患者中静脉血栓栓塞性疾病的发病率明显增高

2021-07-16 MedSci原创 MedSci原创

已知,炎症性肠病 (IBD) 患者的静脉血栓栓塞 (VTE) 疾病风险会比正常人高 3 倍以上,年轻的 IBD 患者的相对风险最大

      已知,炎症性肠病 (IBD) 患者的静脉血栓栓塞 (VTE) 疾病风险会比正常人高 3 倍以上,年轻的 IBD 患者的相对风险最大,但 60 岁以上 IBD 患者的总体绝对风险最高。因此,如果住院 IBD 患者的血栓得到广泛预防,并且更有效的药物和更早的干预策略加强了活动性疾病的治疗,IBD 患者中 VTE 的发生率应该能显着下降。因此,本项研究旨在确定过去 30 年 IBD 中 VTE 的发生率是否有所降低。

 

      研究人员使用基于人群的IBD 流行病学数据库(1984-2018)来确定 IBD 中 VTE 的发病率以及与匹配对照的发病率比。对于伴有和不伴有 VTE 的 IBD 患者,通过多变量逻辑回归评估了与 VTE 风险增加相关的变量。

 

      研究结果显示IBD 队列中 VTE 的发生率为 7.6%,显着高于对照组(3.3%,P < 0.0001)。IBD 中 VTE 的总体年龄标准化发病率为 433/100,000,对照组为 184/100,000。克罗恩病 (8.4%) 的 VTE 发生率高于溃疡性结肠炎 (6.9%, P = 0.0028)。IBD 与对照组的发病率比为 2.36(95% 置信区间 2.16-2.58)。与溃疡性结肠炎相比,男性和女性以及克罗恩病的风险增加相似。1985年至2018年IBD患者发病率下降非常缓慢,年百分比变化为-0.7%(P= 0.0003)。使用肿瘤坏死因子抗体不到 3 年直至 VTE,以及类固醇和肿瘤坏死因子抗体的联合使用增加了 VTE 的风险。

图:炎症性肠病患者中静脉血栓栓塞性疾病的发病率

      本项研究证实尽管在过去 30 年中 IBD 管理取得了进步,但与对照组相比,VTE 的发生率只是缓慢下降并且仍然显着增加。

 

 

原始出处:

Bernstein, Charles N. et al, Persistently High Rate of Venous Thromboembolic Disease in Inflammatory Bowel Disease: A Population-Based Study. The American Journal of Gastroenterology.2021.

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createdBy=f6142500060, createdName=12498710m11暂无昵称, createdTime=Sat Apr 16 15:34:25 CST 2022, time=2022-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940672, encodeId=484f19406e237, content=<a href='/topic/show?id=804499183e8' target=_blank style='color:#2F92EE;'>#静脉血栓栓塞性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99183, encryptionId=804499183e8, topicName=静脉血栓栓塞性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Thu Feb 24 16:34:25 CST 2022, time=2022-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1698234, encodeId=ec10169823432, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat May 28 14:34:25 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057332, encodeId=fb71205e33246, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Sun Sep 12 21:34:25 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068300, encodeId=a35c10683008c, content=学习的, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon Nov 08 22:37:02 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823732, encodeId=571c1823e32bb, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Dec 24 04:34:25 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547458, encodeId=a323154e4587c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561647, encodeId=869d156164e3c, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567656, encodeId=26c4156e65663, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=)]
    2022-05-28 fusion
  5. [GetPortalCommentsPageByObjectIdResponse(id=1955542, encodeId=37c71955542c7, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Thu Jan 13 03:34:25 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037602, encodeId=8477203e6020e, content=<a href='/topic/show?id=8307991822f' target=_blank style='color:#2F92EE;'>#静脉血栓栓塞性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99182, encryptionId=8307991822f, topicName=静脉血栓栓塞性)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat May 28 14:34:25 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057332, encodeId=fb71205e33246, content=<a href='/topic/show?id=18982222db' target=_blank style='color:#2F92EE;'>#AJG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2222, encryptionId=18982222db, topicName=AJG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Sun Sep 12 21:34:25 CST 2021, time=2021-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068300, encodeId=a35c10683008c, content=学习的, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon Nov 08 22:37:02 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823732, encodeId=571c1823e32bb, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Dec 24 04:34:25 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547458, encodeId=a323154e4587c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561647, encodeId=869d156164e3c, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567656, encodeId=26c4156e65663, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=)]
    2021-09-12 minzju5052
  6. [GetPortalCommentsPageByObjectIdResponse(id=1955542, encodeId=37c71955542c7, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Thu Jan 13 03:34:25 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037602, encodeId=8477203e6020e, content=<a href='/topic/show?id=8307991822f' target=_blank style='color:#2F92EE;'>#静脉血栓栓塞性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99182, encryptionId=8307991822f, topicName=静脉血栓栓塞性)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon Nov 08 22:37:02 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823732, encodeId=571c1823e32bb, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Dec 24 04:34:25 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547458, encodeId=a323154e4587c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561647, encodeId=869d156164e3c, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567656, encodeId=26c4156e65663, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=)]
    2021-11-08 1482963am12暂无昵称

    学习的

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon Nov 08 22:37:02 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823732, encodeId=571c1823e32bb, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Dec 24 04:34:25 CST 2021, time=2021-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547458, encodeId=a323154e4587c, content=<a href='/topic/show?id=4ef26e01766' 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  8. 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  9. 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target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561647, encodeId=869d156164e3c, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 18 07:34:25 CST 2021, time=2021-07-18, status=1, ipAttribution=), 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    2021-07-18 liuxiaona
  10. 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炎症性肠病 (IBD) 是一种复杂的全身炎症性疾病,通常伴有肠道和肠外并发症。静脉血栓栓塞 (VTE) 是最具破坏性的肠外IBD 的并发症。

Circ Cardiovasc Interv:使用自膨胀镍钛诺支架专用静脉支架可有效且安全的治疗有症状的髂股静脉阻塞——VIRTUS试验结果

慢性静脉功能不全的特点是下肢静脉回流不畅,其原因可能是深静脉血栓形成后的静脉内梗阻,也可能是外在的静脉压迫。本研究旨在确定专用静脉内支架治疗症状性髂股静脉阻塞的安全性和有效性,研究结果已在线发表于Ci

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2020年10月11日,“世界血栓日“前夕,在浙江省卫生健康委员会指导下,浙江省医疗质量控制与评价办公室与浙江省VTE联盟共同发布《浙江省肺血栓和深静脉血栓规范防治》白皮书。