J Dent Res:牙科治疗后的心肌梗死和缺血性中风风险

2018-11-28 lishiting MedSci原创

侵袭性牙科治疗(IDTs)与心肌梗死(MI)和缺血性中风(IS)的短期风险之间的关系一直存在争议。与IDT相关的口腔和全身炎症引起的细菌扩散会引发急性血管功能障碍。这篇研究的目的是通过设计病例研究对台湾人群的一个大队列数据进行分析以评估IDT与MI和IS之间的关系。

侵袭性牙科治疗(IDTs)与心肌梗死(MI)和缺血性中风(IS)的短期风险之间的关系一直存在争议。与IDT相关的口腔和全身炎症引起的细菌扩散会引发急性血管功能障碍。这篇研究的目的是通过设计病例研究对台湾人群的一个大队列数据进行分析以评估IDT与MI和IS之间的关系。

研究使用病例交叉和自我控制系列病例设计针对全台湾地区的人口,分析台湾地区的国家医疗保健索赔数据库。采用条件logistic回归模型和条件Poisson回归模型评估MI/IS的风险。除此之外,研究使用烧伤患者作为阴性对照探究残余混杂的潜在影响。

结果显示,在病例交叉设计中共包含了123,819名MI患者和327,179名IS患者,在自我控制系列病例设计中共包含了117,655名MI患者和298,757名IS患者。2组试验设计的结果显示,对于MI的风险在IDT后的最初24周接近统一或没有显著性差异,除了在第1周没有其他并存疾病患者存在中等风险以外(风险比[95% confidence intervals] of 1.31 [1.08-1.58] and 1.15 [1.01-1.31] for 3 d and 7 d, respectively)。研究也观察到,IDTs与IS没有联系,或风险几率接近于统一。

结论:IDTs在台湾人群中与MI和IS的短期风险没有联系,并且2组病例研究设计的结果相一致。然而,结果不能排除牙齿的感染和疾病可能会对MI和IS的长期风险产生影响。


原始出处:

Chen TT, D'Aiuto F, et al. Risk of Myocardial Infarction and Ischemic Stroke after Dental Treatments. J Dent Res. 2018 Oct 25:22034518805745. doi: 10.1177/0022034518805745.

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    2018-11-30 xzw115
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    2018-11-29 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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