呼吸

订阅

MedSci主页 / 所有栏目 / 呼吸

AJRCCM: 2022年国内首篇-肺动脉高压患者的认知功能障碍

2022-08-01 刘少飞 MedSci原创

肺动脉高压认知功能障碍
关注

肺动脉高压(PH)是由多种病因引起的肺血管压力逐渐增加的综合征。据报道，PH患者还伴有炎症和脑血流动力学调节受损。然而，这些患者是否存在认知障碍仍不确定。

图片

图片

肺动脉高压(PH)是由多种病因引起的肺血管压力逐渐增加的综合征。其特征是进行性呼吸急促、疲劳和生活质量下降，如运动不耐受、睡眠障碍、焦虑和抑郁。越来越多的证据表明，一些慢性心肺部疾病与炎症、氧化应激和线粒体功能障碍导致的认知障碍有关。据报道，PH患者还伴有炎症和脑血流动力学调节受损。然而，这些患者是否存在认知障碍仍不确定。

针对上述问题，上海市肺科医院肺循环科袁平副研究员和黎金玲主任护师在 同济大学郑加麟教授和夏骁寰研究员指导下，使用简易精神状态检查(MMSE)和蒙特利尔认知评估(MoCA)问卷分析了上海市肺科医院肺循环科收治315例PH患者和315例对照者的认知障碍表现，及认知功能功能障碍与发病风险、严重程度和临床恶化事件之间的关系。结果提示PH患者存在认知障碍，也预疾病的严重程度有关，较低的MMSE和MoCA总评分能独立预测发病风险增加和预后较差等表现。该研究工作首次发现了肺动脉高压疾病进展与神经认知功能变化间的关系，提出了肺脑轴复杂双向互作的重要理念，为肺动脉高压疾病诊断与治疗提供了新的靶标，并提示肺动脉高压患者认知功能异常早期诊断与干预的重要性。上述研究成果于7月29日在线发表于国际权威刊物American Journal of Respiratory and Critical Care Medicine（论文的第一作者为上海市肺科医院肺循环科袁平副研究员和黎金玲主任护师，通讯作者为郑加麟教授、夏骁寰研究员）。

 

图片

 

图1 肺动脉高压患者认知功能障碍。

参考文献：

Ping Yuan, Jinling Li, Jianhui Liu, Hongting Liu, Sugang Gong, Lan Wang, Jinming Liu, Congcong Li, Yi Wang, Xiaohuan Xia, and Jialin C. Zheng. Cognitive dysfunction in patients with pulmonary hypertension. Am J Respir Crit Care Med. 2022 Jul 29. doi: 10.1164/rccm.202204-0726LE. Online ahead of print.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2036749, encodeId=7af12036e497b, content=<a href='/topic/show?id=3bde1518863' target=_blank style='color:#2F92EE;'>#RCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15188, encryptionId=3bde1518863, topicName=RCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d784426, createdName=isabellayj, createdTime=Sat Oct 01 06:15:32 CST 2022, time=2022-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925650, encodeId=8fdd1925650a8, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Jun 07 00:15:32 CST 2023, time=2023-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808681, encodeId=11c51808681e4, content=<a href='/topic/show?id=eade820e7c0' target=_blank style='color:#2F92EE;'>#肺动脉高压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82077, encryptionId=eade820e7c0, topicName=肺动脉高压患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Sat Feb 18 12:15:32 CST 2023, time=2023-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421458, encodeId=959d142145864, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Wed Aug 03 07:15:32 CST 2022, time=2022-08-03, status=1, ipAttribution=)]
    2022-10-01 isabellayj

    #RCC#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2036749, encodeId=7af12036e497b, content=<a href='/topic/show?id=3bde1518863' target=_blank style='color:#2F92EE;'>#RCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15188, encryptionId=3bde1518863, topicName=RCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d784426, createdName=isabellayj, createdTime=Sat Oct 01 06:15:32 CST 2022, time=2022-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925650, encodeId=8fdd1925650a8, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Jun 07 00:15:32 CST 2023, time=2023-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808681, encodeId=11c51808681e4, content=<a href='/topic/show?id=eade820e7c0' target=_blank style='color:#2F92EE;'>#肺动脉高压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82077, encryptionId=eade820e7c0, topicName=肺动脉高压患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Sat Feb 18 12:15:32 CST 2023, time=2023-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421458, encodeId=959d142145864, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Wed Aug 03 07:15:32 CST 2022, time=2022-08-03, status=1, ipAttribution=)]
    2023-06-07 jklm09

    #动脉高压#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2036749, encodeId=7af12036e497b, content=<a href='/topic/show?id=3bde1518863' target=_blank style='color:#2F92EE;'>#RCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15188, encryptionId=3bde1518863, topicName=RCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d784426, createdName=isabellayj, createdTime=Sat Oct 01 06:15:32 CST 2022, time=2022-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925650, encodeId=8fdd1925650a8, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Jun 07 00:15:32 CST 2023, time=2023-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808681, encodeId=11c51808681e4, content=<a href='/topic/show?id=eade820e7c0' target=_blank style='color:#2F92EE;'>#肺动脉高压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82077, encryptionId=eade820e7c0, topicName=肺动脉高压患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Sat Feb 18 12:15:32 CST 2023, time=2023-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421458, encodeId=959d142145864, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Wed Aug 03 07:15:32 CST 2022, time=2022-08-03, status=1, ipAttribution=)]
    2023-02-18 naiwu77

    #肺动脉高压患者#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2036749, encodeId=7af12036e497b, content=<a href='/topic/show?id=3bde1518863' target=_blank style='color:#2F92EE;'>#RCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15188, encryptionId=3bde1518863, topicName=RCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d784426, createdName=isabellayj, createdTime=Sat Oct 01 06:15:32 CST 2022, time=2022-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1925650, encodeId=8fdd1925650a8, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Jun 07 00:15:32 CST 2023, time=2023-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808681, encodeId=11c51808681e4, content=<a href='/topic/show?id=eade820e7c0' target=_blank style='color:#2F92EE;'>#肺动脉高压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82077, encryptionId=eade820e7c0, topicName=肺动脉高压患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Sat Feb 18 12:15:32 CST 2023, time=2023-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421458, encodeId=959d142145864, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Wed Aug 03 07:15:32 CST 2022, time=2022-08-03, status=1, ipAttribution=)]
    2022-08-03 naiwu78

    #功能障碍#

    0

相关资讯

肺动脉高压研究的热点和前沿：2011年至2020年的文献计量和可视化分析

我们的研究旨在利用文献计量分析来说明过去十年中PAH研究的趋势，从而勾勒出PAH的演变。反过来，从分析中获得的数据不仅为我们提供了对演变的全面理解，也为我们提供了与PAH进展相关的未来方向的新见解。

2型糖尿病患者运动中的肺动脉高压是不明原因的劳累性呼吸困难的基础

本研究的目的是比较有和没有不明原因的劳累性呼吸困难的T2DM患者在休息和运动时的心功能和肺血管功能。我们假设，T2DM呼吸困难组的心功能和肺血管功能比非呼吸困难组差。

肺中的氯离子通道:肺动脉高压的挑战和前景

在过去的几十年中，越来越多的氯离子通道和转运蛋白在肺血管和呼吸道的细胞中被发现。这些蛋白质的重要​​性在于其生理功能受损与肺功能失调、结构重塑或遗传性疾病有关。

肺动脉高压所致右心室衰竭的蛋白质组学和代谢组学分析

该研究描述了MCT诱导的PAH进展过程中RV心肌的蛋白质组和代谢组概况，同时也为潜在的治疗目标提供了见解，促进了PAH中RV功能障碍的延缓或逆转。

双能计算机断层扫描测量肺血容量有助于区分肺动脉高压患者

在这项研究中，我们评估了 DECTPA 参数与超声心动图衍生的 SPAP 的相关性，并使用新的基于患者的图像采集协议将这些参数的预测能力与 PH 和右心应变的常规 CTPA 征象进行了比较。

新型 p38 丝裂原活化蛋白激酶抑制剂可逆转缺氧诱导的大鼠肺动脉高压

本工作研究了LASSBio-1824在缺氧+SU5416诱导的（SuHx）PH大鼠心肺系统结构和功能的病理生理变化中的药理作用。