Photodermatol Photoimmunol Photomed:血浆凝胶联合点阵式二氧化碳激光可有效治疗痤疮所致的瘢痕

2022-01-20 MedSci原创 MedSci原创

寻常性痤疮所致的萎缩性痤疮后瘢痕往往永久且难治疗的。萎缩性痤疮后瘢痕的发病率高,对生活质量影响很大,对皮肤科医生来说也是一个治疗上的挑战。

寻常性痤疮所致的萎缩性痤疮后瘢痕往往永久且难治疗的。萎缩性痤疮后瘢痕的发病率高,对生活质量影响很大,对皮肤科医生来说也是一个治疗上的挑战。近日,发表于的一项研究比较了(A)点阵式二氧化碳激光FCL联合皮内注射血浆凝胶,(B)FCL联合外用血浆凝胶,以及(C)FCL单药治疗萎缩性痤疮后疤痕的安全性和有效性。

研究纳入30名面部萎缩性痤疮后疤痕患者,随机分为三组,分别接受上述3组治疗,患者均接受了4次治疗,每次间隔4周。在基线、1个月和6个月的随访时(FU)使用全球疤痕定量分级系统(GSGS)进行客观评估。通过全球审美改善量表(GAIS)和患者满意度进行主观评估。在基线和6个月的随访中采用了DLQI调查问卷。

 

结果显示,根据GSGS的量化评分,A组(68.4%)和B组(63%)的分数下降幅度相当,而且所有评估分数都明显高于C组(41.2%)。在6个月的随访后,A组和B组的评分都有进一步的显著改善,但是C组并没有。基于GAIS和患者的满意度,所有组别之间没有明显的统计学差异。A组和B组的DLQI评分的降低程度相当,然而都明显高于C组(P < .001)。

综上所述,该研究结果表明,血浆凝胶和FCL的组合可显著提高萎缩性痤疮后瘢痕患者的治疗疗效和生活质量。这种治疗方式的主要优点是成本效益高,使用方便,没有免疫反应。

 

原始出处:

 

May Moustafa Mohamed, et al., Treatment of atrophic acne scars: Topical or intralesional plasma gel? Photodermatol Photoimmunol Photomed. 2022 Jan;38(1):29-37. doi: 10.1111/phpp.12712.

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    2022-03-02 liuxiaona
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    2022-01-22 oliver169
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    2022-01-22 lishizhe
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