J Rheumatol:与巨细胞动脉炎复发和糖皮质激素依赖相关的因素

2019-08-27 xiangting MedSci原创

LVV是复发和GC依赖的独立预测因子。需要进一步的前瞻性研究来证实这些发现,并确定LVV患者是否需要不同的治疗方法。

这项研究旨在确定巨细胞动脉炎(GCA)患者复发和糖皮质激素(GC)依赖的特征及相关因素。

研究回顾性分析了326例连续性GCA患者,随访至少12个月。在多因素分析中确定了与复发和GC依赖相关的因素。

对326例患者(73%为女性)进行了62个月的随访(12-262)。随访期间,171例患者(52%)复发,其中113例患者(35%)发生GC依赖。复发患者较少有卒中史(p=0.01),并且成像时大血管血管炎(LVV)比无复发患者更常见(p=0.01)。最初几个月,复发和非复发患者的治疗策略没有差别。与无GC依赖性疾病的患者相比,GC依赖患者的卒中史更少见(p=0.004),并且成像时的LVV更常见(p=0.005)。在多因素分析中,LVV是复发(HR 1.49,95%CI 1.002-2.12; p=0.04)和GC依赖的独立预测因子(OR 2.19,95%CI 1.19-4.05;p=0.01)。与之相反,卒中是复发(HR 0.21,95%CI 0.03-0.68; p=0.005)和GC依赖性疾病的保护性因素(OR 0.10,95%CI 0.001-0.31; p=0.0005)。接受GC保留剂治疗的GC依赖患者的GC治疗时间短于没有使用保留剂的患者(p=0.008)。

在这项研究中,LVV是复发和GC依赖的独立预测因子。需要进一步的前瞻性研究来证实这些发现,并确定LVV患者是否需要不同的治疗方法。

原始出处:

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    2019-10-08 xsm927
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    2019-08-29 wwzzly
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    2019-08-28 qingfengqishi5

    学习了,学习了

    0

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    2019-08-28 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2019-08-27 orangesking

    0

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