Environmental Health :空气污染可能诱发阿尔茨海默病

2021-06-14 MedSci原创 MedSci原创

阿尔茨海默病(AD)是一种退行性中枢神经系统疾病,会损害患者的思维能力、记忆力和行为独立性,并且会导致患者过早死亡,患者从疾病早期进展至重度平均仅需4至5年。

阿尔茨海默病(AD)是一种退行性中枢神经系统疾病,会损害患者的思维能力、记忆力和行为独立性,并且会导致患者过早死亡,患者从疾病早期进展至重度平均仅需45年。该疾病目前无法被阻止或延迟,正在快速成为日益严重的全球健康危机,为患者家庭和国家财政带来巨大负担。 

CCO

越来越多的研究结果表明,空气污染不仅会影响心肺健康以及增加患癌风险,还会导致认知能力下降,增加患阿尔茨海默病 (AD) 和痴呆症的风险。然而,目前仍缺乏空气中的颗粒物PM2.5AD影响的研究。近日,发表在Environmental Health 一项研究显示,在瑞典,每年有 5% 的痴呆病例可归因于PM2.5暴露。

在这项研究中,研究人员为了估计 60 岁以上瑞典人口中因空气污染导致的AD病例数, 使用了PM 2.5最新浓度响应函数 (CRF)。同时,评估了AD直接和间接的终生成本以及无形成本。

结果显示,2019 年瑞典有 260 人有患痴呆症的风险,每年可归因于 PM 2.5暴露的痴呆病例数估计为 820例,占瑞典年度痴呆病例的 5%。年度直接和间接终生成本估计相当于 3290 万欧元,其中 78% 估计发生在社会护理部门。每个痴呆患者直接和间接终生平均成本估计为 213,000 欧元。

每年可归因于 PM 2.5暴露的痴呆病例数和经济成本

同时,据估计,PM 2.5每年减少 1 μg/m 3可减少 101 AD的发生,这相当于在直接和间接的终生成本方面估计减少了 1900 万欧元。

综上,该研究结果表明,瑞典每年有多达 5% AD病例可归因于 PM 2.5暴露。PM 2.5归因于AD的经济负担估计相当于 2019 年瑞典 GDP 0.1%。因此,亟需在公共卫生政策决策中考虑与AD发病率相关的空气中有颗粒物。

原始出处

Hedi Katre Kriit, Bertil ForsbergDaniel Oudin Åström & Anna Oudin .Annual dementia incidence and monetary burden attributable to fine particulate matter (PM2.5) exposure in Sweden.Environmental Health 

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    2021-11-12 shizhenshan
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time=2021-06-16, status=1, ipAttribution=)]
    2021-12-19 jianhe

    环境因素值得重视

    0

  4. 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    2022-02-04 lixiaol
  7. 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  8. 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  9. 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