Nutrients:益生菌混合物用来预防儿童过敏性鼻炎症状

2021-05-18 AlexYang MedSci原创

过敏性疾病在成人和儿童中越来越多。因其存在严重并发症的风险、导致生活质量低下和引起相关费用,因而它是一个公共卫生问题。据估计,超过20%的人口受过敏性疾病的影响,如过敏性鼻炎(AR)、哮喘、食物过敏和

过敏性疾病在成人和儿童中越来越多。因其存在严重并发症的风险、导致生活质量低下和引起相关费用,因而它是一个公共卫生问题。据估计,超过20%的人口受过敏性疾病的影响,如过敏性鼻炎(AR)、哮喘、食物过敏和/或特应性皮炎。

过敏性鼻炎影响了10-25%的普通人群,在过去的几十年里,AR的发病率一直在增加,使其成为一个全球性的健康问题。有研究表明,特定细菌菌种的存在可能影响过敏性疾病的发展。近期,有研究人员提出肠道微生物群假说来解释过敏性疾病发病率的上升原因。

由于益生菌具有抗炎和免疫调节作用,因此也许可以用于预防过敏反应。该研究中,研究人员用动物双歧杆菌亚种BB12和粪肠球菌L3的混合物进行预防性治疗,调查是否能减少过敏性鼻炎(AR)患儿的症状和用药需求

研究包括了250名6至17岁的儿童,均患有AR,并将他们随机分配到干预组(150人)或安慰剂组(100人)。干预组患者除接受常规治疗(局部皮质激素和/或口服抗组胺药)外,在与儿童最敏感的过敏原有关的症状出现前3个月,每天口服含有动物双歧杆菌亚种BB12 DSM 15954和粪肠球菌L3 LMG P-27496菌株的益生菌混合物。最后使用鼻腔症状评分(NSS)来评估使用益生菌或安慰剂治疗前后的AR严重程度。

结果表明,干预组的患者在益生菌治疗后,其NSS明显下降(P=2.2×10-10)。此外,干预组患者的药物治疗摄入量的显著减少。即口服抗组胺药(p=2.2×10-16)、局部皮质激素(p=2.2×10-13)和两种药物(p-value 1.5 × 10-15)的使用均减少。

干预组中AR的药物治疗情况

他们的研究认为,BB12和L3的混合物作为预防性治疗时,在统计学上减少了AR的体征和症状,并明显减少了对常规治疗的需求

原始出处:

Caterina Anania, Vincenza Patrizia Di Marino, Francesca Olivero et al. Treatment with a Probiotic Mixture Containing Bifidobacterium animalis Subsp. Lactis BB12 and Enterococcus faecium L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial. Nutrients. Apr 2021

 

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    2021-06-19 zutt
  4. [GetPortalCommentsPageByObjectIdResponse(id=2047411, encodeId=1a35204e41106, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Jan 04 01:38:24 CST 2022, time=2022-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754047, encodeId=25121e540477c, content=<a href='/topic/show?id=dd6f2849351' target=_blank style='color:#2F92EE;'>#儿童过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28493, encryptionId=dd6f2849351, topicName=儿童过敏性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aff136654610, createdName=charl1234579, createdTime=Sat Mar 05 13:38:24 CST 2022, time=2022-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069455, encodeId=cac0206945532, content=<a href='/topic/show?id=c4ad28491a8' target=_blank style='color:#2F92EE;'>#儿童过敏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28491, encryptionId=c4ad28491a8, topicName=儿童过敏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Jun 19 12:38:24 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998119, encodeId=886d998119e6, content=是有益的尝试, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6af1554625, createdName=8242649, createdTime=Sat Jul 10 06:31:46 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=966675, encodeId=338f9666e5ce, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3cc35503886, createdName=ms8000000197177051, createdTime=Tue May 18 22:20:32 CST 2021, time=2021-05-18, status=1, ipAttribution=)]
    2021-07-10 8242649

    是有益的尝试

    0

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    2021-05-18 ms8000000197177051

    非常棒

    0

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