Breast:奥氮平可有效预防中国乳腺癌患者化疗所致恶心呕吐

2021-02-27 MedSci原创 MedSci原创

辅助化疗可以改善早期乳腺癌患者的治疗效果,但化疗引起的恶心和呕吐(CINV)为患者带来了难以忍受的痛苦。奥氮平是硫代苯二氮卓类非典型抗精神病药物,可拮抗与恶心和呕吐发病机制有关的几种受体,一项随机研究

辅助化疗可以改善早期乳腺癌患者的治疗效果,但化疗引起的恶心和呕吐(CINV)为患者带来了难以忍受的痛苦。奥氮平是硫代苯二氮卓类非典型抗精神病药物,可拮抗与恶心和呕吐发病机制有关的几种受体,一项随机研究评估了标准止吐方案联合或不联合奥氮平的对化疗患者的止吐疗效,发现联合奥氮平可更好的改善CINV,研究结果已发表于Breast。

研究纳入120名计划进行(新)辅助治疗多柔比星/环磷酰胺的患者。所有研究人群的止吐方案包括阿普瑞坦、昂丹司琼和地塞米松,随机将其分为奥氮平(含奥氮平)或标准组(不含奥氮平)。患者填写自我报告的日记,并完成恶心的视觉模拟量表,以及功能性生活指数-Emesis问卷。监测了包括空腹血糖和血脂在内的血液资料。

 

结果显示,在第1周期多柔比星/环磷酰胺中,奥氮平组的"完全反应"率显著高于标准组:总体期65.0% vs 38.3%(P = 0.0035),急性期70.0% vs 51.7%(P = 0.0397),延迟期92.9% vs 74.2%(P = 0.0254)。在所有3个时间段内奥氮平组"无明显恶心"和"无恶心"的比例也显著较高,且QOL较好。在整个多个周期中也有类似的发现。研究前奥氮平组39.7%和标准组34.2%的患者血糖和血脂异常,在研究结束评估时,两组之间这些参数没有差异。

综上所述,该研究结果表明,将奥氮平加入到基于阿普瑞巴林的标准止吐方案中,可更好的改善CINV。在接受多柔比星/环磷酰胺化疗的中国乳腺癌患者中,这与对QOL和可耐受毒性谱的改善有关。但是仍需对乳腺癌患者的代谢谱行进一步的研究。

 

原始出处:

 

Winnie YeoThomas Kh Lau, et al., A randomized study of olanzapine-containing versus standard antiemetic regimens for the prevention of chemotherapy-induced nausea and vomiting in Chinese breast cancer patients. Breast. 2020 Apr;50:30-38. doi: 10.1016/j.breast.2020.01.005.  

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    2021-04-07 ms6000001015893838

    已看,还可以。

    0

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    2021-03-18 ms3000001780497766

    谢谢分享

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210228/82badaa27d3e4f0a9d2d10a1e9534e52/a9bcc4db6dbc4847bd69f5a15be7a33d.jpg, createdBy=7e105464058, createdName=灿君drugs, createdTime=Sun Feb 28 22:55:22 CST 2021, time=2021-02-28, status=1, ipAttribution=)]
    2021-03-02 桂枝汤不要桂枝

    不知在其他癌症化疗后恶心呕吐是否同样有效

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1712719, encodeId=37691e1271971, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon May 10 21:09:19 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954942, encodeId=86159549426f, content=已看,还可以。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1bc65476534, createdName=ms6000001015893838, createdTime=Wed Apr 07 16:22:23 CST 2021, time=2021-04-07, status=1, ipAttribution=), 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210228/82badaa27d3e4f0a9d2d10a1e9534e52/a9bcc4db6dbc4847bd69f5a15be7a33d.jpg, createdBy=7e105464058, createdName=灿君drugs, createdTime=Sun Feb 28 22:55:22 CST 2021, time=2021-02-28, status=1, ipAttribution=)]
  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=1712719, encodeId=37691e1271971, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon May 10 21:09:19 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=954942, encodeId=86159549426f, content=已看,还可以。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1bc65476534, createdName=ms6000001015893838, createdTime=Wed Apr 07 16:22:23 CST 2021, time=2021-04-07, status=1, ipAttribution=), 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topicId=null, topicList=[TopicDto(id=3712, encryptionId=12e43e1263, topicName=Breast)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 01 14:09:19 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944395, encodeId=2dcb94439529, content=奥氮有效预防乳腺癌患者化疗中的恶心呕吐, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Mon Mar 01 12:35:40 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944297, encodeId=db9894429e0c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210228/82badaa27d3e4f0a9d2d10a1e9534e52/a9bcc4db6dbc4847bd69f5a15be7a33d.jpg, createdBy=7e105464058, createdName=灿君drugs, createdTime=Sun Feb 28 22:55:22 CST 2021, time=2021-02-28, status=1, ipAttribution=)]
    2021-03-01 zhaojie88
  9. 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    2021-03-01 科研科研科研

    奥氮有效预防乳腺癌患者化疗中的恶心呕吐

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210228/82badaa27d3e4f0a9d2d10a1e9534e52/a9bcc4db6dbc4847bd69f5a15be7a33d.jpg, createdBy=7e105464058, createdName=灿君drugs, createdTime=Sun Feb 28 22:55:22 CST 2021, time=2021-02-28, status=1, ipAttribution=)]
    2021-02-28 灿君drugs

    学习了

    0

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