AP&T: 卡维地洛的使用与肝硬化患者的生存改善有关

2021-01-25 MedSci原创 MedSci原创

肝硬化容易造成消化道出血,是因为肝硬化引起的胃底食管静脉曲张,出现破裂出血,肝硬化胃底食管静脉曲张,是肝硬化失代偿期比较明显的症状,也是门静脉高压的表现。

      肝硬化容易造成消化道出血,是因为肝硬化引起的胃底食管静脉曲张,出现破裂出血,肝硬化胃底食管静脉曲张,是肝硬化失代偿期比较明显的症状,也是门静脉高压的表现。现在,非选择性β受体阻滞剂(NSBB)或静脉曲张带结扎术(VBL)预防静脉曲张破裂出血是门静脉高压性肝硬化患者的标准治疗方法。NSBB药物尤其是卡维地洛,可能与生存改善有关。因此,本项研究旨在评估使用卡维地洛或VBL患者死亡率的差异。

 

 

      研究人员回顾性分析了2000年4月7日至2006年6月24日期间参加多中心随机对照试验的152例患者,所有患者均接受了VBL或卡维地洛的治疗。研究人员使用电子记录病例档案对所有患者进行了长期随访(最长长达20年),其主要观察结果是全因死亡率以及肝相关死亡率和失代偿事件(腹水,脑病,静脉曲张破裂出血)。

 

 

      本项研究共纳入了152例患者,使用卡维地洛(n = 77)和VBL(n = 75)组之间的基线数据可比。在意向性治疗分析中,卡维地洛具有显着的生存优势,中位生存期为7.8年,而VBL组为4.2年(P = 0.03)。当排除在治疗组之间交叉的患者时,卡维地洛组的这种生存优势(P = 0.02)依然明显。两组的无移植存活率,肝相关死亡率和代偿失调事件相似。

 

      本项研究表明卡维地洛对肝硬化和门静脉高压症患者具有明显的生存益处。

 

 

原始出处:

Hannah R. McDowell. Et al. Carvedilol is associated with improved survival in patients with cirrhosis: a long‐term follow‐up study. Alimentary Pharmacology & Therapeutics.2021.

 

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    2021-08-01 ms1000002016287811

    学习了

    0

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    2021-02-05 ms1000002016287811

    已学习。

    0

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    2021-01-25 ms9000000784262906

    学习了

    0

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    2021-01-25 guging

    谢谢!最新的信息读起来就是收获大

    0

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    2021-01-25 loveangel1982

    学习了

    0

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