Gastroenterology:低FODMAP饮食可缓解季候性炎症性肠病患者的肠道症状

2020-08-01 MedSci原创 MedSci原创

有限的证据表明,低发酵低聚糖、二糖、单糖和多元醇(FODMAPs)饮食可以减少静止性炎症性肠病(IBD)的肠道症状。我们进行了一项随机对照试验,研究低FODMAP饮食对静止期IBD患者持续肠道症状、肠

有限的证据表明,低发酵低聚糖、二糖、单糖和多元醇(FODMAPs)饮食可以减少静止性炎症性肠病(IBD)的肠道症状。我们进行了一项随机对照试验,研究低FODMAP饮食对静止期IBD患者持续肠道症状、肠道微生物组和循环炎症标志物的影响。

 

我们进行了一项单盲试验,52名患者与静止的克罗恩病或溃疡性结肠炎和持续的肠道症状在2个大型胃肠病诊所在英国。患者被随机分配到遵循低FODMAPs饮食(n = 27)或控制饮食(n = 25)的组,并提供饮食建议,为期4周。使用有效的问卷测量肠道症状和健康相关的生活质量。在基线和试验结束时收集粪便和血液样本。使用枪式元基因组测序评估粪便微生物组组成和功能,使用流式细胞仪评估血液中T细胞的表型。

 

结果显示,较高比例的患者报告低FODMAP饮食后肠道症状得到充分缓解(14/27,52%),高于对照饮食(4/25,16%,P=.007)。患者在低FODMAP饮食后,肠易激综合征严重程度评分的降低幅度(平均降低67;标准误差,78)大于对照饮食(平均降低34;标准误差,50),尽管这种差异没有统计学意义(P=.075)。在低FODMAP饮食后,患者的健康相关生活质量评分(81.9±1.2)高于对照饮食的患者(78.3±1.2,P = .042)。有针对性的分析显示,在研究期结束时收集的粪便样本中,低FODMAP饮食的患者的青春双歧杆菌、长双歧杆菌和普氏杆菌的丰度显著低于对照饮食的患者。然而,组间微生物组多样性和炎症标志物无显著差异。

 

综上所述,该研究结果表明,为期4周的低FODMAPs饮食对于管理静止期IBD患者的持续肠道症状是安全和有效的。

 

原始出处:

 

Selina R CoxJames O Lindsay, et al., Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial. Gastroenterology. 2020 Jan;158(1):176-188.e7. doi: 10.1053/j.gastro.2019.09.024. 

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    2020-11-06 许安
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    2020-11-23 148b9707m67暂无昵称

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