Eur Respir J:肥胖和正常体重哮喘患者哮喘药物分析

2020-09-18 MedSci原创 MedSci原创

尽管FEV1较低且FEV1/FVC%较低,肥胖的哮喘患者使用的哮喘药物种类和ICS剂量均高于正常体重的哮喘患者。需要更好地了解导致药物使用增加的因素,以改善哮喘亚组的预后。

肥胖症是哮喘的常见合并症,与哮喘控制不良、病情频繁发作/加重以及对哮喘药物治疗反应性降低有关。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,这篇综述旨在比较肥胖(BMI≥30kg·m-2)和健康体重(BMI<25 kg·m-2)哮喘患者使用各种哮喘药物的疗效。

研究人员检索了CINAHL、Cochrane、EMBASE和MEDLINE数据库,以确定2019年7月之前发表的英文研究,这些研究记录了肥胖和健康体重的哮喘患者药物使用或剂量。关键评估清单被用于审查合格研究的方法学质量。研究人员进行了荟萃分析,并使用χ2检验评估异质性。这项系统评价是根据已发布的协议(PROSPERO:CRD42020148671)进行的。

荟萃分析结果显示,肥胖受试者更可能使用哮喘药物,包括;短效β2-激动剂[比值比(OR)=1.75;95%CI:1.17-2.60;与健康体重的受试者相比,p=0.006,I2=41%]和持续的口服糖皮质激素治疗(OR=1.86;95%CI:1.49,2.31; p<0.001,I2=0%)。肥胖受试者的吸入糖皮质激素剂量(μg/天)显著更高(平均差异=208.14;95%CI:107.01,309.27;p<0.001,I2=74%)。肥胖受试者的FEV1%预测值显著较低(平均差异=-5.32%; 95%CI:-6.75,-3.89; p<0.001,I2=42%),但是,组间FEV1/FVC%未观察到显著差异。

由此可见,尽管FEV1较低且FEV1/FVC%较低,肥胖的哮喘患者使用的哮喘药物种类和ICS剂量均高于正常体重的哮喘患者。需要更好地了解导致药物使用增加的因素,以改善哮喘亚组的预后。

原始出处:

Cherry A. Thompson,et al.Asthma medication use in obese and healthy weight asthma: systematic review/meta-analysis.Eur Respir J.2020.https://erj.ersjournals.com/content/early/2020/09/03/13993003.00612-2020

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2035646, encodeId=55052035646b9, content=<a href='/topic/show?id=5fa83995011' target=_blank style='color:#2F92EE;'>#哮喘药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39950, encryptionId=5fa83995011, topicName=哮喘药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Tue Dec 15 19:49:04 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908500, encodeId=f0a3908500fc, content=长期吸入ics甚至口服了ics 也导致肥胖、代谢疾病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:11:57 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661239, encodeId=82a71661239c0, content=<a href='/topic/show?id=af898e6860b' target=_blank style='color:#2F92EE;'>#药物分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87686, encryptionId=af898e6860b, topicName=药物分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0f525243979, createdName=ms6390871039024434, createdTime=Fri Jun 18 08:49:04 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886346, encodeId=43b788634607, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f36a5419325, createdName=ms4000000368985602, createdTime=Fri Sep 18 11:19:24 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886383, encodeId=b6a38863839b, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=156e5419308, createdName=ms2000001082092203, createdTime=Fri Sep 18 13:46:54 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-12-15 huangdf
  2. [GetPortalCommentsPageByObjectIdResponse(id=2035646, encodeId=55052035646b9, content=<a href='/topic/show?id=5fa83995011' target=_blank style='color:#2F92EE;'>#哮喘药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39950, encryptionId=5fa83995011, topicName=哮喘药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Tue Dec 15 19:49:04 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908500, encodeId=f0a3908500fc, content=长期吸入ics甚至口服了ics 也导致肥胖、代谢疾病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:11:57 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661239, encodeId=82a71661239c0, content=<a href='/topic/show?id=af898e6860b' target=_blank style='color:#2F92EE;'>#药物分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87686, encryptionId=af898e6860b, topicName=药物分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0f525243979, createdName=ms6390871039024434, createdTime=Fri Jun 18 08:49:04 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886346, encodeId=43b788634607, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f36a5419325, createdName=ms4000000368985602, createdTime=Fri Sep 18 11:19:24 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886383, encodeId=b6a38863839b, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=156e5419308, createdName=ms2000001082092203, createdTime=Fri Sep 18 13:46:54 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-12-16 潛心學習者

    长期吸入ics甚至口服了ics 也导致肥胖、代谢疾病。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2035646, encodeId=55052035646b9, content=<a href='/topic/show?id=5fa83995011' target=_blank style='color:#2F92EE;'>#哮喘药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39950, encryptionId=5fa83995011, topicName=哮喘药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Tue Dec 15 19:49:04 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908500, encodeId=f0a3908500fc, content=长期吸入ics甚至口服了ics 也导致肥胖、代谢疾病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:11:57 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661239, encodeId=82a71661239c0, content=<a href='/topic/show?id=af898e6860b' target=_blank style='color:#2F92EE;'>#药物分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87686, encryptionId=af898e6860b, topicName=药物分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0f525243979, createdName=ms6390871039024434, createdTime=Fri Jun 18 08:49:04 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886346, encodeId=43b788634607, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f36a5419325, createdName=ms4000000368985602, createdTime=Fri Sep 18 11:19:24 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886383, encodeId=b6a38863839b, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=156e5419308, createdName=ms2000001082092203, createdTime=Fri Sep 18 13:46:54 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2035646, encodeId=55052035646b9, content=<a href='/topic/show?id=5fa83995011' target=_blank style='color:#2F92EE;'>#哮喘药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39950, encryptionId=5fa83995011, topicName=哮喘药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Tue Dec 15 19:49:04 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908500, encodeId=f0a3908500fc, content=长期吸入ics甚至口服了ics 也导致肥胖、代谢疾病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:11:57 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661239, encodeId=82a71661239c0, content=<a href='/topic/show?id=af898e6860b' target=_blank style='color:#2F92EE;'>#药物分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87686, encryptionId=af898e6860b, topicName=药物分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0f525243979, createdName=ms6390871039024434, createdTime=Fri Jun 18 08:49:04 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886346, encodeId=43b788634607, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f36a5419325, createdName=ms4000000368985602, createdTime=Fri Sep 18 11:19:24 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886383, encodeId=b6a38863839b, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=156e5419308, createdName=ms2000001082092203, createdTime=Fri Sep 18 13:46:54 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 ms4000000368985602

    好文章

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2035646, encodeId=55052035646b9, content=<a href='/topic/show?id=5fa83995011' target=_blank style='color:#2F92EE;'>#哮喘药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39950, encryptionId=5fa83995011, topicName=哮喘药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Tue Dec 15 19:49:04 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908500, encodeId=f0a3908500fc, content=长期吸入ics甚至口服了ics 也导致肥胖、代谢疾病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:11:57 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661239, encodeId=82a71661239c0, content=<a href='/topic/show?id=af898e6860b' target=_blank style='color:#2F92EE;'>#药物分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87686, encryptionId=af898e6860b, topicName=药物分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0f525243979, createdName=ms6390871039024434, createdTime=Fri Jun 18 08:49:04 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886346, encodeId=43b788634607, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f36a5419325, createdName=ms4000000368985602, createdTime=Fri Sep 18 11:19:24 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886383, encodeId=b6a38863839b, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=156e5419308, createdName=ms2000001082092203, createdTime=Fri Sep 18 13:46:54 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 ms2000001082092203

    不错的文章

    0

相关资讯

Immunol Lett:过敏性鼻炎中Omalizumab的长期疗效如何?

在治疗不佳的重症哮喘患者中,Omalizumab作为附加疗法是安全和有效的。虽然在过去的十年中,有一些研究表明Omalizumab在其他免疫球蛋白E相关疾病中的疗效,但其在鼻炎和哮喘疾病中的使用仍旧未

广西一患者遵医嘱服用十倍药物后进ICU 医院致歉

针对“遵医嘱服用十倍药物后,患者昏迷进ICU”一事,9月17日下午,广西医科大学第二附属医院发布声明称,目前患者仍在医院接受康复治疗,各项指标已基本恢复至发病前状态,医院对该事

翰森制药:上半年收入净利润双降,1创新2首仿6款药物获批

亿欧大健康9月3日消息,翰森制药集团有限公司(以下简称“翰森制药”)近日发布其2020年中期业绩公告。上半年,翰森制药实现收入39.80亿元,同比下降13.5%,净利润12.2

J Inflamm Res:新研究鉴定了BX471对变应性鼻炎的治疗作用

变应性鼻炎(AR)是一种免疫球蛋白E (IgE)介导的炎症性呼吸过敏,其特征是Th2细胞因子升高和炎症细胞向鼻组织浸润。BX471是一种小分子C-C趋化因子受体1型(CCR1)拮抗剂,它通过阻断初级配

从入选主席研讨会到燃爆全球,听WCLC大会主席吴一龙教授谈胸膜间皮瘤治疗新突破

免疫治疗方案在经过不断地优化和调整后,在多个临床研究中均表现出高度的安全性。在该研究中,纳武利尤单抗联合伊匹木单抗的安全性与既往报道的研究结果一致,未观察到新的安全性信号。

又一种罕见病药物国内上市,全国仅约300名患者

近日,武田制药的瑞普佳(阿加糖酶α注射用浓溶液)经国家药监局批准,用于确诊为法布雷病(α-半乳糖苷酶A缺乏症)患者的长期酶替代治疗。