Chest:吸烟者的社区不利因素与肺癌发病率

2019-12-19 xiangting MedSci原创

即使在调整个体变量后,人口普查得出的邻里状况仍与肺癌发病率有很强关联。

邻里环境对多种健康结局都有影响,但是邻里环境与肺癌发病率之间的关联尚未得到详细研究。这项研究试图分析调整个人吸烟暴露和其他危险因素后,吸烟者的周围环境是否与肺癌发病率独立相关。

根据研究社区医疗保健系统提供的19年电子健康记录数据,组成了一个55岁以上的吸烟者队列。确定了患者的人口学和其他已知与肺癌相关的指标。指数访问时患者地址被编码到普查区组级别,以确定区域剥夺指数(ADI),该指数是根据美国社区调查的5年估算得出的。多元Cox比例风险模型适用于评估ADI与肺癌诊断时间的关联。进行双侧统计学显著性检验。

研究包括19867名男性和21748名女性。53%的患者为白人,38%为黑人,5%为西班牙裔。其中,1,149人患上肺癌。调整已知危险因素后,与优势地区患者相比,最弱势地区的患者肺癌发病率明显升高(HR 1.2995CI 1.07-1.55)。

即使在调整个体变量后,人口普查得出的邻里状况仍与肺癌发病率有很强关联。需要进一步的研究探讨将周围环境与肺癌联系起来的机制。

原始出处:

Yosra Adie. Neighborhood Disadvantage and Lung Cancer Incidence in Ever-Smokers at a Safety-Net Healthcare System: A Retrospective Study. Chest. 17 December 2019.

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    2020-05-09 Smile2680
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