神经科

订阅

MedSci主页 / 所有栏目 / 神经科

JNNP:晚发性维生素B2转运蛋白缺乏症与各种运动神经病病因关联

2020-10-29 MedSci原创 MedSci原创

维生素B2运动神经病BVVL
关注

核黄素转运蛋白缺陷（RTDs）涉及SLC52A3和SLC52A2基因，核黄素或维生素B2（7,8-二甲基-10-三甲基异四氧嘧啶）是一种重要的水溶性维生素，是黄素单核苷酸和黄素腺嘌呤二核苷酸的前体。这

核黄素转运蛋白缺陷（RTDs）涉及SLC52A3和SLC52A2基因，核黄素或维生素B2（7,8-二甲基-10-三甲基异四氧嘧啶）是一种重要的水溶性维生素，是黄素单核苷酸和黄素腺嘌呤二核苷酸的前体。这些辅酶在许多细胞酶反应中起辅助作用，特别是在能量代谢（线粒体β氧化）和氨基酸和脂质合成中。核黄素的饮食摄入来自牛奶、肉类，油性鱼类和绿色蔬菜，儿童每日摄入量为0.4毫克，哺乳期妇女为1.6毫克。 SLC52A2和SLC52A3蛋白质具有不同的组织分布，并作为核黄素从消化腔输送到不同器官的细胞，包括中枢神经系统。研究显示，近年来RTDs与进行性桥延麻痹伴耳聋(Brown Vialetto Van Laere（BVVL）综合征（一种与运动神经病变（MN）和耳聋相关的遗传性疾病）有关。bvvl/RTD在成人患者中很少有报道，但由于神经科医生对bvvl/RTD缺乏认识，可能是诊断不足。在这项研究中，我们旨在探讨RTD患者晚发性MN的表型和预后。

方法:回顾性收集所有10岁后（n=6）发生MN的法国RTD患者的临床、生物学和电生理资料，并从其他19例类似RTD患者中提取数据。共有25名患者被纳入本研究。将队列中的每个患者分为四种不同的MN表型之一：（1）肌萎缩侧索硬化（ALS）或远端遗传性运动神经病变（dHMN）的下运动神经元（LMN）综合征，具有弥漫性MN和慢性病程；（2）多颅性神经病变（MCN）多发性痣，急性或亚急性MN首先累及脑神经，包括I和VIII神经；（3）急性运动神经病（AMN）类似于炎症性神经病变（Guillain-Barrésyndrome）和（4）混合运动和感觉神经病变（MSN），脊髓前角为运动神经元，背根神经节为感觉神经元，无长度依赖型，运动和感觉分离表现。

结果：成人伴MN的RTD患者具有不同的临床表现，可能类似于肌萎缩侧索硬化症或远端遗传性运动神经病变（56%）、累及颅神经的多发性痣（16%）、格林-巴雷综合征（8%）和混合运动和感觉神经病变综合征（仅SLC52A2患者）。耳聋通常是在MN（44%）之前被诊断出来的，但是在一些患者中，耳聋只从MN开始（16%）。BVVL中描述的典型的桥小脑麻痹不是恒定的。生化测试通常是正常的。大多数患者在补充核黄素后好转（86%）。

虽然，晚发性RTD可能体现运动神经病变的不同获得性或遗传性原因，但由于每次口服高剂量核黄素通常是非常有效的，因此这是一个值得研究的症状。

Carreau C, Benoit C, Ahle G, et al Late-onset riboflavin transporter deficiency: a treatable mimic of various motor neuropathy aetiologies Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 21 October 2020. doi: 10.1136/jnnp-2020-323304

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1696362, encodeId=9a3016963621f, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Wed Apr 21 08:25:16 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739659, encodeId=c0661e3965911, content=<a href='/topic/show?id=e90de90610c' target=_blank style='color:#2F92EE;'>#维生素B2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79061, encryptionId=e90de90610c, topicName=维生素B2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jul 02 09:25:16 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906517, encodeId=a5fa90651e10, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJn78WsrwImFiaEsHwy2oexCiakad5kzY2oiaiaYSh8bWSLwrk85ic9W1QXD8rdYtW1ZEjVa0tiax8Stayw/132, createdBy=258e2267706, createdName=ms3198164387790639, createdTime=Wed Dec 09 23:24:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897490, encodeId=c1f689e490d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKsCFCNsYeQh51BvlZXoqiabU3hQK0zHYwAHMYunnicEEdjeA9Jh1tJSo0V7JTm3fSAQabDCQzGbKoQ/0, createdBy=20842168228, createdName=wxlh1991, createdTime=Sat Nov 07 05:29:45 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895789, encodeId=a923895e89aa, content=维生素B12与运动神经病因关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Oct 31 00:25:05 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491384, encodeId=8fa01491384fa, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508556, encodeId=00c81508556be, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895247, encodeId=da4b89524e82, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Thu Oct 29 08:01:04 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2021-04-21 yzh409

    #转运#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1696362, encodeId=9a3016963621f, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Wed Apr 21 08:25:16 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739659, encodeId=c0661e3965911, content=<a href='/topic/show?id=e90de90610c' target=_blank style='color:#2F92EE;'>#维生素B2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79061, encryptionId=e90de90610c, topicName=维生素B2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jul 02 09:25:16 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906517, encodeId=a5fa90651e10, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJn78WsrwImFiaEsHwy2oexCiakad5kzY2oiaiaYSh8bWSLwrk85ic9W1QXD8rdYtW1ZEjVa0tiax8Stayw/132, createdBy=258e2267706, createdName=ms3198164387790639, createdTime=Wed Dec 09 23:24:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897490, encodeId=c1f689e490d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKsCFCNsYeQh51BvlZXoqiabU3hQK0zHYwAHMYunnicEEdjeA9Jh1tJSo0V7JTm3fSAQabDCQzGbKoQ/0, createdBy=20842168228, createdName=wxlh1991, createdTime=Sat Nov 07 05:29:45 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895789, encodeId=a923895e89aa, content=维生素B12与运动神经病因关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Oct 31 00:25:05 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491384, encodeId=8fa01491384fa, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508556, encodeId=00c81508556be, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895247, encodeId=da4b89524e82, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Thu Oct 29 08:01:04 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2021-07-02 智者为医08

    #维生素B2#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1696362, encodeId=9a3016963621f, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Wed Apr 21 08:25:16 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739659, encodeId=c0661e3965911, content=<a href='/topic/show?id=e90de90610c' target=_blank style='color:#2F92EE;'>#维生素B2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79061, encryptionId=e90de90610c, topicName=维生素B2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jul 02 09:25:16 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906517, encodeId=a5fa90651e10, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJn78WsrwImFiaEsHwy2oexCiakad5kzY2oiaiaYSh8bWSLwrk85ic9W1QXD8rdYtW1ZEjVa0tiax8Stayw/132, createdBy=258e2267706, createdName=ms3198164387790639, createdTime=Wed Dec 09 23:24:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897490, encodeId=c1f689e490d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKsCFCNsYeQh51BvlZXoqiabU3hQK0zHYwAHMYunnicEEdjeA9Jh1tJSo0V7JTm3fSAQabDCQzGbKoQ/0, createdBy=20842168228, createdName=wxlh1991, createdTime=Sat Nov 07 05:29:45 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895789, encodeId=a923895e89aa, content=维生素B12与运动神经病因关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Oct 31 00:25:05 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491384, encodeId=8fa01491384fa, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508556, encodeId=00c81508556be, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895247, encodeId=da4b89524e82, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Thu Oct 29 08:01:04 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-12-09 ms3198164387790639

    学习一下

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1696362, encodeId=9a3016963621f, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Wed Apr 21 08:25:16 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739659, encodeId=c0661e3965911, content=<a href='/topic/show?id=e90de90610c' target=_blank style='color:#2F92EE;'>#维生素B2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79061, encryptionId=e90de90610c, topicName=维生素B2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jul 02 09:25:16 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906517, encodeId=a5fa90651e10, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJn78WsrwImFiaEsHwy2oexCiakad5kzY2oiaiaYSh8bWSLwrk85ic9W1QXD8rdYtW1ZEjVa0tiax8Stayw/132, createdBy=258e2267706, createdName=ms3198164387790639, createdTime=Wed Dec 09 23:24:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897490, encodeId=c1f689e490d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKsCFCNsYeQh51BvlZXoqiabU3hQK0zHYwAHMYunnicEEdjeA9Jh1tJSo0V7JTm3fSAQabDCQzGbKoQ/0, createdBy=20842168228, createdName=wxlh1991, createdTime=Sat Nov 07 05:29:45 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895789, encodeId=a923895e89aa, content=维生素B12与运动神经病因关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Oct 31 00:25:05 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491384, encodeId=8fa01491384fa, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508556, encodeId=00c81508556be, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895247, encodeId=da4b89524e82, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Thu Oct 29 08:01:04 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-11-07 wxlh1991

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1696362, encodeId=9a3016963621f, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Wed Apr 21 08:25:16 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739659, encodeId=c0661e3965911, content=<a href='/topic/show?id=e90de90610c' target=_blank style='color:#2F92EE;'>#维生素B2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79061, encryptionId=e90de90610c, topicName=维生素B2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jul 02 09:25:16 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906517, encodeId=a5fa90651e10, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJn78WsrwImFiaEsHwy2oexCiakad5kzY2oiaiaYSh8bWSLwrk85ic9W1QXD8rdYtW1ZEjVa0tiax8Stayw/132, createdBy=258e2267706, createdName=ms3198164387790639, createdTime=Wed Dec 09 23:24:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897490, encodeId=c1f689e490d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKsCFCNsYeQh51BvlZXoqiabU3hQK0zHYwAHMYunnicEEdjeA9Jh1tJSo0V7JTm3fSAQabDCQzGbKoQ/0, createdBy=20842168228, createdName=wxlh1991, createdTime=Sat Nov 07 05:29:45 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895789, encodeId=a923895e89aa, content=维生素B12与运动神经病因关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Oct 31 00:25:05 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491384, encodeId=8fa01491384fa, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508556, encodeId=00c81508556be, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895247, encodeId=da4b89524e82, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Thu Oct 29 08:01:04 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-10-31 146465bem06暂无昵称

    维生素B12与运动神经病因关联

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1696362, encodeId=9a3016963621f, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Wed Apr 21 08:25:16 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739659, encodeId=c0661e3965911, content=<a href='/topic/show?id=e90de90610c' target=_blank style='color:#2F92EE;'>#维生素B2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79061, encryptionId=e90de90610c, topicName=维生素B2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jul 02 09:25:16 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906517, encodeId=a5fa90651e10, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJn78WsrwImFiaEsHwy2oexCiakad5kzY2oiaiaYSh8bWSLwrk85ic9W1QXD8rdYtW1ZEjVa0tiax8Stayw/132, createdBy=258e2267706, createdName=ms3198164387790639, createdTime=Wed Dec 09 23:24:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897490, encodeId=c1f689e490d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKsCFCNsYeQh51BvlZXoqiabU3hQK0zHYwAHMYunnicEEdjeA9Jh1tJSo0V7JTm3fSAQabDCQzGbKoQ/0, createdBy=20842168228, createdName=wxlh1991, createdTime=Sat Nov 07 05:29:45 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895789, encodeId=a923895e89aa, content=维生素B12与运动神经病因关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Oct 31 00:25:05 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491384, encodeId=8fa01491384fa, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508556, encodeId=00c81508556be, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895247, encodeId=da4b89524e82, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Thu Oct 29 08:01:04 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-10-30 axin012

    #神经病#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1696362, encodeId=9a3016963621f, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Wed Apr 21 08:25:16 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739659, encodeId=c0661e3965911, content=<a href='/topic/show?id=e90de90610c' target=_blank style='color:#2F92EE;'>#维生素B2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79061, encryptionId=e90de90610c, topicName=维生素B2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jul 02 09:25:16 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906517, encodeId=a5fa90651e10, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJn78WsrwImFiaEsHwy2oexCiakad5kzY2oiaiaYSh8bWSLwrk85ic9W1QXD8rdYtW1ZEjVa0tiax8Stayw/132, createdBy=258e2267706, createdName=ms3198164387790639, createdTime=Wed Dec 09 23:24:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897490, encodeId=c1f689e490d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKsCFCNsYeQh51BvlZXoqiabU3hQK0zHYwAHMYunnicEEdjeA9Jh1tJSo0V7JTm3fSAQabDCQzGbKoQ/0, createdBy=20842168228, createdName=wxlh1991, createdTime=Sat Nov 07 05:29:45 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895789, encodeId=a923895e89aa, content=维生素B12与运动神经病因关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Oct 31 00:25:05 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491384, encodeId=8fa01491384fa, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508556, encodeId=00c81508556be, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895247, encodeId=da4b89524e82, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Thu Oct 29 08:01:04 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-10-30 马龙

    #维生素B#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1696362, encodeId=9a3016963621f, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Wed Apr 21 08:25:16 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739659, encodeId=c0661e3965911, content=<a href='/topic/show?id=e90de90610c' target=_blank style='color:#2F92EE;'>#维生素B2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79061, encryptionId=e90de90610c, topicName=维生素B2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jul 02 09:25:16 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906517, encodeId=a5fa90651e10, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJn78WsrwImFiaEsHwy2oexCiakad5kzY2oiaiaYSh8bWSLwrk85ic9W1QXD8rdYtW1ZEjVa0tiax8Stayw/132, createdBy=258e2267706, createdName=ms3198164387790639, createdTime=Wed Dec 09 23:24:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897490, encodeId=c1f689e490d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKsCFCNsYeQh51BvlZXoqiabU3hQK0zHYwAHMYunnicEEdjeA9Jh1tJSo0V7JTm3fSAQabDCQzGbKoQ/0, createdBy=20842168228, createdName=wxlh1991, createdTime=Sat Nov 07 05:29:45 CST 2020, time=2020-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895789, encodeId=a923895e89aa, content=维生素B12与运动神经病因关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Sat Oct 31 00:25:05 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491384, encodeId=8fa01491384fa, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508556, encodeId=00c81508556be, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Oct 30 15:25:16 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895247, encodeId=da4b89524e82, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Thu Oct 29 08:01:04 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-10-29 13c30453m58暂无昵称

    学习学习学习学习

    0

相关资讯

Orphanet J Rare Dis：维生素B2对这种罕见的线粒体疾病有效

德国慕尼黑理工大学人类遗传学研究所领导的团队近日对70名ACAD9缺陷型个体的临床、生化和遗传图谱进行全面分析。他们还评估了核黄素对患者的作用，并发表在罕见病杂志《Orphanet Journal of Rare Diseases》上。