BJU Int:新辅助化疗在肌层浸润性膀胱癌和恶性输尿管梗阻患者中的安全性研究

2021-04-18 AlexYang MedSci原创

最近,有研究人员确定了肌层浸润性膀胱癌和输尿管阻塞的患者是否可以安全地接受新辅助顺铂化疗(NAC)。同时,确定了该类患者在开始NAC之前是否需要用输尿管支架或经皮肾造瘘术(PCN)缓解梗阻。

最近,有研究人员确定了肌层浸润性膀胱癌和输尿管阻塞的患者是否可以安全地接受新辅助顺铂化疗(NAC)。同时,确定了该类患者在开始NAC之前是否需要用输尿管支架或经皮肾造瘘术(PCN)缓解梗阻

研究人员对接受NAC的MIBC患者进行了单机构的回顾性分析。患者分为三组:NO=无输尿管梗阻组;RO=已缓解的输尿管梗阻组;URO=未缓解的输尿管梗阻。为了了解梗阻患者是否可以安全地接受NAC,研究人员将NO患者与RO患者进行比较(即是否过早地停止化疗)。为了研究梗阻患者是否应该在NAC之前缓解梗阻,研究人员以≥3级不良事件、过早化疗中止、剂量减少或剂量中断为主要组成结果,比较了RO与URO患者的情况。

研究人员共分析了193名NO患者、49名RO患者和35名URO患者。结果表明,NO患者与RO患者在化疗中断(15% vs 22%,p=0.3)或任何次要结果上均无统计学意义上的显著差异。RO患者和URO患者在主要组成结果(51% vs 53%,p=1)或任何次要结果方面也没有统计学意义的显著差异。

最后,研究人员指出,输尿管梗阻患者可以安全地接受NAC。梗阻的缓解与NAC治疗的安全性增加无关

原始出处:

Marshall C Strother , Alexander Kutikov , Matthew Epstein et al. Safety of Neoadjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer and Malignant Ureteral Obstruction. BJU Int. Mar 2021

 

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    学习学习

    0

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    2021-04-18 留走人康

    膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效

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