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Arthritis Res Ther：研究发现 IL12B区域新的易感位点与大动脉炎病理生理关联的机制

2017-09-08 MedSci MedSci原创

IL12B大动脉炎单核苷酸多态性
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既往研究发现大动脉炎（TAK）易感性和位于IL12B的单核苷酸多态性（SNP）rs6871626相关，它编码白细胞介素（IL）- 12p40，由IL-12p70和IL-23共同组成。本研究旨在探究TAK患者中这些细胞因子的表达，区分存在或不存在rs6871626 SNP风险等位基因的患者。研究共纳入了44名TAK患者和19名健康对照者（HCs），使用酶联免疫吸附试验评估其血浆IL-12p40、IL

既往研究发现大动脉炎（TAK）易感性和位于IL12B的单核苷酸多态性（SNP）rs6871626相关，它编码白细胞介素（IL）- 12p40，由IL-12p70和IL-23共同组成。本研究旨在探究TAK患者中这些细胞因子的表达，区分存在或不存在rs6871626 SNP风险等位基因的患者。

研究共纳入了44名TAK患者和19名健康对照者（HCs），使用酶联免疫吸附试验评估其血浆IL-12p40、IL-12p70和IL-23的水平。从20名TAK患者和14 名HCs获得单核细胞，使用干扰素（IFNγ）和脂多糖处理，然后确定上清液中细胞因子的水平。此外，使用流式细胞仪检测外周血单核细胞确定IFN-γ+ 或 IL-17A+细胞与CD4 + T细胞的比率。

结果显示，TAK患者血浆IL-12p40及 IL-12p70，和上清IL-12p70的水平明显高于HCs，而血浆IL-23，和上清IL-23及IL-12p40的水平两组之间并无明显差异。存在风险等位基因的患者其血浆IL-12p70，上清IL-12p40及IL-12p70显著高于无风险等位基因者。存在风险等位基因的患者CD4+IFN-γ+细胞比率明显升高，而CD4+IL-17A+则无明显差异。

总之，该研究结果表明，IL12B的rs6871626 SNP可能会增加IL-12p40和IL-12p70的表达水平。而这些表达升高的细胞因子可能在TAK的病理生理学中发挥作用。

原始出处：

Toshiki Nakajima, Hajime Yoshifuji, et al., A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production. Arthritis Res Ther. 2017; 19: 197. Published online 2017 Sep 6. doi: 10.1186/s13075-017-1408-8.

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    2018-06-16 hanhaisha2020

    #研究发现#

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    2018-01-06 ms6390871039024434

    #Arthritis#

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    2017-09-17 许安

    #病理生理#

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Jan 06 00:34:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701770, encodeId=49301e017706d, content=<a href='/topic/show?id=9c35e104573' target=_blank style='color:#2F92EE;'>#病理生理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71045, encryptionId=9c35e104573, topicName=病理生理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d59730392519, createdName=许安, createdTime=Sun Sep 17 00:34:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683174, encodeId=118f16831e4c1, content=<a href='/topic/show?id=60f03325e28' target=_blank style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Fri Feb 09 19:34:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019023, encodeId=d5da20190237b, content=<a href='/topic/show?id=64fe59656df' target=_blank style='color:#2F92EE;'>#易感位点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59656, encryptionId=64fe59656df, topicName=易感位点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5eee468, createdName=zxl729, createdTime=Wed May 02 18:34:00 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329938, encodeId=730d132993828, content=<a href='/topic/show?id=6124436201d' target=_blank style='color:#2F92EE;'>#大动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43620, encryptionId=6124436201d, topicName=大动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Sun Sep 10 11:34:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356504, encodeId=87e213565046f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 10 11:34:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241889, encodeId=95e12418894b, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Fri Sep 08 22:04:25 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241881, encodeId=6f5a24188192, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Sep 08 21:51:56 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2018-02-09 xsm927

    #动脉炎#

    0

  5. 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style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Fri Feb 09 19:34:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019023, encodeId=d5da20190237b, content=<a href='/topic/show?id=64fe59656df' target=_blank style='color:#2F92EE;'>#易感位点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59656, encryptionId=64fe59656df, topicName=易感位点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5eee468, createdName=zxl729, createdTime=Wed May 02 18:34:00 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329938, encodeId=730d132993828, content=<a href='/topic/show?id=6124436201d' target=_blank style='color:#2F92EE;'>#大动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43620, encryptionId=6124436201d, topicName=大动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Sun Sep 10 11:34:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356504, encodeId=87e213565046f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 10 11:34:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241889, encodeId=95e12418894b, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Fri Sep 08 22:04:25 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241881, encodeId=6f5a24188192, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Sep 08 21:51:56 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2018-05-02 zxl729

    #易感位点#

    0

  6. 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style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Fri Feb 09 19:34:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019023, encodeId=d5da20190237b, content=<a href='/topic/show?id=64fe59656df' target=_blank style='color:#2F92EE;'>#易感位点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59656, encryptionId=64fe59656df, topicName=易感位点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5eee468, createdName=zxl729, createdTime=Wed May 02 18:34:00 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329938, encodeId=730d132993828, content=<a href='/topic/show?id=6124436201d' target=_blank style='color:#2F92EE;'>#大动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43620, encryptionId=6124436201d, topicName=大动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Sun Sep 10 11:34:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356504, encodeId=87e213565046f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 10 11:34:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241889, encodeId=95e12418894b, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Fri Sep 08 22:04:25 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241881, encodeId=6f5a24188192, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Sep 08 21:51:56 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-10 ms3153534357578991

    #大动脉炎#

    0

  7. 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style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Fri Feb 09 19:34:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019023, encodeId=d5da20190237b, content=<a href='/topic/show?id=64fe59656df' target=_blank style='color:#2F92EE;'>#易感位点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59656, encryptionId=64fe59656df, topicName=易感位点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5eee468, createdName=zxl729, createdTime=Wed May 02 18:34:00 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329938, encodeId=730d132993828, content=<a href='/topic/show?id=6124436201d' target=_blank style='color:#2F92EE;'>#大动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43620, encryptionId=6124436201d, topicName=大动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Sun Sep 10 11:34:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356504, encodeId=87e213565046f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 10 11:34:00 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241889, encodeId=95e12418894b, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Fri Sep 08 22:04:25 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241881, encodeId=6f5a24188192, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Sep 08 21:51:56 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-10 zhaojie88

    #ART#

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Sep 08 21:51:56 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-08 189****7206

    学习了受益匪浅

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Sep 08 21:51:56 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-08 changjiu

    学习了.谢谢

    0