Inflamm Bowel Dis:膳食铁与血红素铁的消耗与炎症性肠病发生率的关系

2017-06-13 许奕晗 MedSci原创

膳食铁与血红素铁可以通过对患者肠道共生菌和肠屏障功能的影响来调节结肠炎症,但是膳食摄取铁总量和血红素铁对于克罗恩病(CD)与溃疡性结肠炎(UC)发病率之间的关系还没有研究报道。

膳食铁与血红素铁可以通过对患者肠道共生菌和肠屏障功能的影响来调节结肠炎症,但是膳食摄取铁总量和血红素铁对于克罗恩病(CD)与溃疡性结肠炎(UC)发病率之间的关系还没有研究报道。

最近,有一项研究筛选了165331名美国妇女,进行了护理健康研究一期和二期的前瞻性队列研究。通过膳食信息采集表收集患者的饮食数据,患者IBD诊断临床医生检查并确认。研究人员采用Cox模型和Logistic回归模型对CD和UC的全基因组单核苷酸多态性与膳食摄铁总量和血红素铁之间的关系。

本项研究随访了自从2011年以来登记住院过的IBD患者,共261例CD患者和321例UC患者,发现膳食血红素铁与UC发病风险的增加无明显关系(P=0.12),与CD的发病率增加也无关(P=0.67)。同时,发现饮食摄铁总量与CD和UC发病率的增加也没有统计学差异。

原始出处:


Khalili, Hamed.et al.Dietary Iron and Heme Iron Consumption,Genetic Susceptibility,and Risk of Crohn's Disease and Ulcerative Colitis.Inflamm Bowel Dis.June 09,2017.
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    2018-03-12 lxg951
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topicName=Bow)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Wed Jan 10 15:26:00 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215270, encodeId=eafe2152e025, content=不错 学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbkwiamQRUZ02EtNQ6eQflk4CHafHibKTV9ju5ia6AkEvQuZagYnTGsFTuibpHDwZUicuFmVBsIZ0qbJg/0, createdBy=bc812071404, createdName=xuyihan, createdTime=Sun Jun 25 15:44:08 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350325, encodeId=65bf135032568, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454813, encodeId=6e101454813c1, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512079, encodeId=c46415120e96a, content=<a href='/topic/show?id=29b28986491' target=_blank style='color:#2F92EE;'>#血红素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89864, encryptionId=29b28986491, topicName=血红素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef8a10431556, createdName=ms1692212821629096, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512672, encodeId=8a7815126e269, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547052, encodeId=7b70154e0521e, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2018-01-10 yuandd
  5. 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style='color:#2F92EE;'>#血红素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89864, encryptionId=29b28986491, topicName=血红素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef8a10431556, createdName=ms1692212821629096, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512672, encodeId=8a7815126e269, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547052, encodeId=7b70154e0521e, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2017-06-25 xuyihan

    不错 学习了

    0

  6. 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topicName=Bow)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Wed Jan 10 15:26:00 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215270, encodeId=eafe2152e025, content=不错 学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbkwiamQRUZ02EtNQ6eQflk4CHafHibKTV9ju5ia6AkEvQuZagYnTGsFTuibpHDwZUicuFmVBsIZ0qbJg/0, createdBy=bc812071404, createdName=xuyihan, createdTime=Sun Jun 25 15:44:08 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350325, encodeId=65bf135032568, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, 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style='color:#2F92EE;'>#血红素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89864, encryptionId=29b28986491, topicName=血红素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef8a10431556, createdName=ms1692212821629096, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512672, encodeId=8a7815126e269, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547052, encodeId=7b70154e0521e, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2017-06-15 zhaojie88
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547052, encodeId=7b70154e0521e, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu Jun 15 14:26:00 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2017-06-15 xiaoyeshuang
  8. 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  9. 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  10. 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肌肉减少症与炎症性肠病(IBD)手术治疗概率、患者死亡率的上升有关,但是肌肉减少症对于IBD手术的影响还没有文献报道。最近,一份研究收集了美国国家外科医师学院IBD患者手术质量改善资料,并就患者围术期并发症进行了回顾性研究分析。首先采用Hounsfield单位平均值法对患者进行术前断层扫描计算。对于肌肉减少症的定义为:Hounsfield单位平均值低于最低的第25百分位数。患者并发症采用Cla

Gut:CD177+中性粒细胞负性调节IBD!

由此可见,CD177+中性粒细胞是具有功能活性的亚群,在IBD中通过增加杀菌活性和IL-22的生产来发挥保护作用。针对CD177+中性粒细胞的治疗策略可能有益于IBD的治疗。

PLos One:炎症性肠病患者的生活保健费用和住院费用

寿命终止(EOL)的护理需要很大的成本,特别是急性护理服务。在炎症性肠病(IBD)患者中,由于依赖医院服务和昂贵的诊断测试和治疗,EOL的成本可能会更多。近期,一项发表在杂志PLos One上的研究旨在比较IBD与非IBD患者之间的EOL医疗保健用途和成本。研究者们使用相关的健康管理数据,对2010年至2013年期间加拿大安大略省所有死亡人员进行了回顾性队列研究。对IBD(N = 2,214)和非