Clin Gastroenterol H:哮喘与IBD之间不得不说的秘密

2017-06-19 许奕晗 MedSci原创

炎症性肠病(IBD)是由免疫介导的肠道疾病,而肺部的疾病如哮喘也可以由相同的因素驱动,这两者之间是否存在联系,近期有学者进行了研究。

炎症性肠病IBD)是由免疫介导的肠道疾病,而肺部的疾病如哮喘也可以由相同的因素驱动,这两者之间是否存在联系,近期有学者进行了研究。

目前对于IBD、哮喘以及相关的一些免疫介导的疾病发病率的增加,社会主流观点是认为与我们所处的卫生条件的改善有关,包括清洁饮用水,居住条件改善等等。这些卫生条件的改善导致了微生物和抗原暴露在早期就消失了,从而引发我们免疫系统功能的机会就丧失了。

四十多年来,一直有研究相关研究试图表明IBD与肺部疾病之间的联系,在最近的一期Clinical Gastroenterology and Hepatology杂志上,来自加拿大艾伯塔省的研究人员启动了一项基于全体人群的病例对照研究,采集了哮喘患者于IBD患者的诊疗数据,评估哮喘的发生于IBD发病之间的关系。

研究结果显示:患有哮喘病史的患者CD发生的可能性是明显增加(OR=1.45;95%CI:1.31~1.60),哮喘与UC的发病率之间的关系与患者年龄有关,16岁以下的患者哮喘与UC的关系是OR=1.49,95%CI:1.08~2.07,40岁以下的患者OR=1.57,95%CI:1.31~1.89。

如果这项研究的结果是正确的,我们就不得不考虑哮喘的发生是否增加了IBD的发病风险,虽然哮喘本身不太可能直接诱导IBD的发生,但是肺部炎症可能是IBD的驱动因素,用于治疗哮喘的药物,例如口服的类固醇激素也可能增加IBD的发病几率,所以在以后对于IBD的诊疗工作中对于肺部一些特异性炎症疾病要引起足够的重视,对于哮喘类型与IBD之间的关系还有待进一步研究。

原始出处:


Edward L. Barnes .Do Shared Exposures Link the Lungs and Gut?Association Between Asthma and Inflammatory Bowel Disease.Clinical Gastroenterology and Hepatology.2017.

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    2018-01-21 许安
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    2017-06-20 bnurmamat
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    2017-06-20 xuyihan

    真的吗

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2071811, encodeId=486a20e1811a2, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Jan 21 12:44:00 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711089, encodeId=1c481e1108970, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Mar 02 22:44:00 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064137, encodeId=ebb7206413e96, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Apr 05 03:44:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263437, encodeId=dc0f126343ef0, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Jun 20 21:44:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213173, encodeId=bb4e2131e331, content=真的吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbkwiamQRUZ02EtNQ6eQflk4CHafHibKTV9ju5ia6AkEvQuZagYnTGsFTuibpHDwZUicuFmVBsIZ0qbJg/0, createdBy=bc812071404, createdName=xuyihan, createdTime=Tue Jun 20 18:23:39 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212687, encodeId=835521268ebd, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Mon Jun 19 09:50:07 CST 2017, time=2017-06-19, status=1, ipAttribution=)]
    2017-06-19 1dd7a091m35(暂无匿称)

    学习了。。。。

    0