Hypertension:心血管疾病老年人动脉僵硬的短期预后效应

2019-11-05 xing.T MedSci原创

由此可见,该研究的结果进一步支持cfPWV作为动脉僵硬度的指标以及连接了动脉僵硬与心力衰竭发展之间的关系,但也提示老年人动脉僵硬的预后价值有限。

通过颈动脉股脉搏波速度(cfPWV)衡量的动脉僵硬度可预测心血管疾病(CVD)。但是,在老年人群中,这种关联似乎减弱了。此外,脉搏波速度在不同动脉段的预后价值以及诸如心踝血管指数(CAVI)之类的新参数仍然不清楚,尤其是在美国老年人中。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,在3034年没有CVD的社区动脉粥样硬化风险(ARIC)研究参与者(66-90岁)中,研究人员评估了4种脉搏波速度测量指标(cfPWV、心脏-股动脉、臂踝、心踝)和2种新的动脉硬化测量方法(分别来自心踝和股骨的CAVI和股骨血管指数)与CVD(冠心病、卒中和心力衰竭)和全因死亡率之间的关系。

在4.4年的中位随访期间中,有168起CVD事件和244例死亡。总体而言,除了cfPWV以外,动脉硬度指标并未显示出与CVD之间具有较强的相关性,cfPWV甚至在调整了潜在的混杂因素后仍显示出与CVD之间的J形相关性(最高四分位数与第3四分位数相比风险比为1.83 [95%CI为1.08-3.09],而最低四分位数与第3四分位数相比风险比为1.97[1.14–3.39])。当分别评估每个CVD时,心力衰竭与较高的cfPWV密切相关,而卒中与较低的cfPWV密切相关,与全因死亡率没有显著关联。在脉搏波速度的不同测量方法中,cfPWV在没有CVD的老年人中显示出与CVD的关联性最强,尤其是心力衰竭。其他脉搏波速度指标与CVD之间没有强关联性。

由此可见,该研究的结果进一步支持cfPWV作为动脉僵硬度的指标以及连接了动脉僵硬与心力衰竭发展之间的关系,但也提示老年人动脉僵硬的预后价值有限。 

原始出处:

Esther D. Kim.et al.Short-Term Prognostic Impact of Arterial Stiffness in Older Adults Without Prevalent Cardiovascular Disease.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13496

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    2020-08-23 feather89

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