PLOS Medicine:低脂不代表健康!食用橄榄油、坚果和鱼类,可显著改善血管内皮恢复稳态和再生!

2020-09-18 王木木 生物探索

高血压、冠心病等心血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子。

高血压、冠心病等血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子,是动脉粥样硬化性疾病发生发展的主要机制。

维持正确的内皮功能需要保持活性氧(ROS)产生平衡,减少促凋亡因素,以及通过血管生成再生内皮细胞的能力。有研究表明包括饮食在内的生活因素会影响内皮功能,例如饱和脂肪酸(SFA)丰富的饮食会对内皮功能造成损害,但对于调整长期饮食能否改变内皮功能进而降低CVD的复发率目前仍未可知。

近日,来自西班牙科尔多瓦大学和美国塔夫茨大学医学院的研究人员在《PLOS Medicine》上发表了题为Mediterranean diet and endothelial function inpatients with coronary heart disease: An analysis of the Cordioprev randomizedcontrolled trial的研究成果。该报告发现,与低脂饮食相比,地中海饮食能更好地调节冠心病患者血管内皮的恢复和稳态平衡,增强再生内皮细胞的能力,进而可能会改善动脉粥样硬化,降低心血管疾病的复发率。

研究人员招募了805名冠心病患者,将其分为两组,分别进行以橄榄油、蔬菜水果和鱼类坚果为主的地中海饮食以及以碳水化合物为主的低脂饮食,干预一年后通过检测血管中流量介导的扩张(FMD, 较低的 FMD 值与较高的心血管事件发生率和全因死亡率相关)、内皮微粒(EMPs,损伤后内皮细胞膜形成的小泡)水平、内皮祖细胞(EPCs,与维持内皮完整性和功能有关)以及EMPs/EPCs 比率(血管稳态不平衡的标志),对其血管的内皮功能进行评估,并详细研究了膳食对与内皮功能障碍和血管内皮稳态相关的生物学过程的影响机制。

对检测结果进行分析后,研究人员发现,地中海饮食干预后人群的胆固醇水平更高,而空腹血糖水平和高敏C反应蛋白水平降低。与基线期相比,地中海饮食组患者的血流介导的血管扩张(FMD)均增加,同时也显着高于低脂饮食组患者 ,组间差异分别为2.63%,这一差异在严重内皮功能障碍的人群中更为明显。

饮食干预对根据内皮功能障碍严重程度分类的患者的内皮功能相关的参数的影响

对内皮修复机制和内皮损伤标志物进行研究发现,与低脂饮食相比,地中海饮食组的EPC 水平更高,而EMP 水平较低,EMP/epc比值也较高。此外,相比低脂饮食,地中海饮食干预可显着减少血管内皮的胞内活性氧产生、细胞凋亡及细胞衰老,并促进细胞增殖与血管的生成,即其细胞内皮再生能力得到增强。

饮食干预对体外细胞内 ROS 产生和细胞凋亡的影响

研究人员还发现,不同的饮食干预与内皮细胞不同的表观遗传及蛋白组学变化相关。地中海饮食可导致冠心病患者载脂蛋白f 和 e、谷胱甘肽、过氧化物酶3(可催化ROS降低)等的下调和补体因子h、四联蛋白、β2-微球蛋白和载脂蛋白 C-II等的上调,而低脂饮食中出现刚好相反的状况。与低脂饮食相比,地中海饮食干预后有5种miRNA水平降低,另有24种miRNA水平升高,这些miRNA参与调控着细胞的增殖、凋亡、衰老以及ROS合成等,进而影响内皮的修复和稳态。

简而言之,该项研究表明,地中海饮食能更好地调节血管内皮功能,维持血管稳态环境,甚至增加再生内皮细胞能力。对于健康人群来讲,使用健康的地中海饮食方式可以使营养均衡,身体更健康,对于CVD患者,则更应该多食用橄榄油、坚果鱼类蔬菜等,而不是一味认为低脂就会健康。

原始出处:

Elena M Yubero-Serrano, Carolina Fernandez-Gandara, Antonio Garcia-Rios ,et al.Mediterranean diet and endothelial function in patients with coronary heart disease: An analysis of the CORDIOPREV randomized controlled trial.PLoS Med. 2020 Sep 9;17(9):e1003282. doi: 10.1371/journal.pmed.1003282. eCollection 2020 Sep.

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    2020-12-15 kalseyzl
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    2021-06-01 jeanqiuqiu
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style='color:#2F92EE;'>#鱼类#</a>,可显著改善<a href='/topic/show?id=99398953845' target=_blank style='color:#2F92EE;'>#血管内皮#</a>恢复稳态和再生!这些都是有益的零食!!适当的坚果,对健康相当有利, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63020, encryptionId=21db630200b, topicName=橄榄油), TopicDto(id=41489, encryptionId=d04f4148924, topicName=坚果), TopicDto(id=102873, encryptionId=4c511028e37f, topicName=鱼类), TopicDto(id=89538, encryptionId=99398953845, topicName=血管内皮)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:53:20 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889273, encodeId=babb8892e3ba, content=收货良多, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ee15237778, createdName=147b43c6m81暂无昵称, createdTime=Tue Sep 29 20:07:27 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888232, encodeId=ccb68882323c, content=高血压、冠心病等心血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:37:45 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887949, encodeId=0e9188e9497b, content=该项研究表明,地中海饮食能更好地调节血管内皮功能,维持血管稳态环境,甚至增加再生内皮细胞能力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Sep 24 14:15:11 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886865, encodeId=f5f7886865b0, content=科普文, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211221/3698211ff26948b5adc54b42c3637b7d/907441c2db554d41ad40a8f68b613640.jpg, createdBy=aa715419755, createdName=ms7000000098649996, createdTime=Sun Sep 20 14:51:57 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577745, encodeId=2a4d15e77457d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610708, encodeId=79e11610e083c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2021-07-04 changfy
  4. [GetPortalCommentsPageByObjectIdResponse(id=1773883, encodeId=f84b1e7388367, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Tue Dec 15 22:41:20 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1859077, encodeId=b45618590e743, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Tue Jun 01 05:41:20 CST 2021, time=2021-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646759, encodeId=890f1646e5911, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Sun Jul 04 14:41:20 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895298, encodeId=3b7f89529878, content=低脂不代表健康!食用<a href='/topic/show?id=21db630200b' target=_blank style='color:#2F92EE;'>#橄榄油#</a>、<a href='/topic/show?id=d04f4148924' target=_blank style='color:#2F92EE;'>#坚果#</a>和<a href='/topic/show?id=4c511028e37f' target=_blank style='color:#2F92EE;'>#鱼类#</a>,可显著改善<a href='/topic/show?id=99398953845' target=_blank style='color:#2F92EE;'>#血管内皮#</a>恢复稳态和再生!这些都是有益的零食!!适当的坚果,对健康相当有利, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63020, encryptionId=21db630200b, topicName=橄榄油), TopicDto(id=41489, encryptionId=d04f4148924, topicName=坚果), TopicDto(id=102873, encryptionId=4c511028e37f, topicName=鱼类), TopicDto(id=89538, encryptionId=99398953845, topicName=血管内皮)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:53:20 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889273, encodeId=babb8892e3ba, content=收货良多, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ee15237778, createdName=147b43c6m81暂无昵称, createdTime=Tue Sep 29 20:07:27 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888232, encodeId=ccb68882323c, content=高血压、冠心病等心血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:37:45 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887949, encodeId=0e9188e9497b, content=该项研究表明,地中海饮食能更好地调节血管内皮功能,维持血管稳态环境,甚至增加再生内皮细胞能力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Sep 24 14:15:11 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886865, encodeId=f5f7886865b0, content=科普文, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211221/3698211ff26948b5adc54b42c3637b7d/907441c2db554d41ad40a8f68b613640.jpg, createdBy=aa715419755, createdName=ms7000000098649996, createdTime=Sun Sep 20 14:51:57 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577745, encodeId=2a4d15e77457d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610708, encodeId=79e11610e083c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2020-10-29 lovetcm

    低脂不代表健康!食用#橄榄油##坚果##鱼类#,可显著改善#血管内皮#恢复稳态和再生!这些都是有益的零食!!适当的坚果,对健康相当有利

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1773883, encodeId=f84b1e7388367, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Tue Dec 15 22:41:20 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1859077, encodeId=b45618590e743, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Tue Jun 01 05:41:20 CST 2021, time=2021-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646759, encodeId=890f1646e5911, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Sun Jul 04 14:41:20 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895298, encodeId=3b7f89529878, content=低脂不代表健康!食用<a href='/topic/show?id=21db630200b' target=_blank style='color:#2F92EE;'>#橄榄油#</a>、<a href='/topic/show?id=d04f4148924' target=_blank style='color:#2F92EE;'>#坚果#</a>和<a href='/topic/show?id=4c511028e37f' target=_blank style='color:#2F92EE;'>#鱼类#</a>,可显著改善<a href='/topic/show?id=99398953845' target=_blank style='color:#2F92EE;'>#血管内皮#</a>恢复稳态和再生!这些都是有益的零食!!适当的坚果,对健康相当有利, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63020, encryptionId=21db630200b, topicName=橄榄油), TopicDto(id=41489, encryptionId=d04f4148924, topicName=坚果), TopicDto(id=102873, encryptionId=4c511028e37f, topicName=鱼类), TopicDto(id=89538, encryptionId=99398953845, topicName=血管内皮)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:53:20 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889273, encodeId=babb8892e3ba, content=收货良多, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ee15237778, createdName=147b43c6m81暂无昵称, createdTime=Tue Sep 29 20:07:27 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888232, encodeId=ccb68882323c, content=高血压、冠心病等心血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:37:45 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887949, encodeId=0e9188e9497b, content=该项研究表明,地中海饮食能更好地调节血管内皮功能,维持血管稳态环境,甚至增加再生内皮细胞能力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Sep 24 14:15:11 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886865, encodeId=f5f7886865b0, content=科普文, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211221/3698211ff26948b5adc54b42c3637b7d/907441c2db554d41ad40a8f68b613640.jpg, createdBy=aa715419755, createdName=ms7000000098649996, createdTime=Sun Sep 20 14:51:57 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577745, encodeId=2a4d15e77457d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610708, encodeId=79e11610e083c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2020-09-29 147b43c6m81暂无昵称

    收货良多

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1773883, encodeId=f84b1e7388367, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Tue Dec 15 22:41:20 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1859077, encodeId=b45618590e743, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Tue Jun 01 05:41:20 CST 2021, time=2021-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646759, encodeId=890f1646e5911, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Sun Jul 04 14:41:20 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895298, encodeId=3b7f89529878, content=低脂不代表健康!食用<a href='/topic/show?id=21db630200b' target=_blank style='color:#2F92EE;'>#橄榄油#</a>、<a href='/topic/show?id=d04f4148924' target=_blank style='color:#2F92EE;'>#坚果#</a>和<a href='/topic/show?id=4c511028e37f' target=_blank style='color:#2F92EE;'>#鱼类#</a>,可显著改善<a href='/topic/show?id=99398953845' target=_blank style='color:#2F92EE;'>#血管内皮#</a>恢复稳态和再生!这些都是有益的零食!!适当的坚果,对健康相当有利, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63020, encryptionId=21db630200b, topicName=橄榄油), TopicDto(id=41489, encryptionId=d04f4148924, topicName=坚果), TopicDto(id=102873, encryptionId=4c511028e37f, topicName=鱼类), TopicDto(id=89538, encryptionId=99398953845, topicName=血管内皮)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:53:20 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889273, encodeId=babb8892e3ba, content=收货良多, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ee15237778, createdName=147b43c6m81暂无昵称, createdTime=Tue Sep 29 20:07:27 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888232, encodeId=ccb68882323c, content=高血压、冠心病等心血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:37:45 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887949, encodeId=0e9188e9497b, content=该项研究表明,地中海饮食能更好地调节血管内皮功能,维持血管稳态环境,甚至增加再生内皮细胞能力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Sep 24 14:15:11 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886865, encodeId=f5f7886865b0, content=科普文, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211221/3698211ff26948b5adc54b42c3637b7d/907441c2db554d41ad40a8f68b613640.jpg, createdBy=aa715419755, createdName=ms7000000098649996, createdTime=Sun Sep 20 14:51:57 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577745, encodeId=2a4d15e77457d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610708, encodeId=79e11610e083c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2020-09-25 咻凡

    高血压、冠心病等心血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子。

    0

  7. 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style='color:#2F92EE;'>#鱼类#</a>,可显著改善<a href='/topic/show?id=99398953845' target=_blank style='color:#2F92EE;'>#血管内皮#</a>恢复稳态和再生!这些都是有益的零食!!适当的坚果,对健康相当有利, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63020, encryptionId=21db630200b, topicName=橄榄油), TopicDto(id=41489, encryptionId=d04f4148924, topicName=坚果), TopicDto(id=102873, encryptionId=4c511028e37f, topicName=鱼类), TopicDto(id=89538, encryptionId=99398953845, topicName=血管内皮)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:53:20 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889273, encodeId=babb8892e3ba, content=收货良多, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ee15237778, createdName=147b43c6m81暂无昵称, createdTime=Tue Sep 29 20:07:27 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888232, encodeId=ccb68882323c, content=高血压、冠心病等心血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:37:45 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887949, encodeId=0e9188e9497b, content=该项研究表明,地中海饮食能更好地调节血管内皮功能,维持血管稳态环境,甚至增加再生内皮细胞能力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Sep 24 14:15:11 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886865, encodeId=f5f7886865b0, content=科普文, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211221/3698211ff26948b5adc54b42c3637b7d/907441c2db554d41ad40a8f68b613640.jpg, createdBy=aa715419755, createdName=ms7000000098649996, createdTime=Sun Sep 20 14:51:57 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577745, encodeId=2a4d15e77457d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610708, encodeId=79e11610e083c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2020-09-24 Lexi

    该项研究表明,地中海饮食能更好地调节血管内皮功能,维持血管稳态环境,甚至增加再生内皮细胞能力。

    0

  8. 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createdName=jeanqiuqiu, createdTime=Tue Jun 01 05:41:20 CST 2021, time=2021-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646759, encodeId=890f1646e5911, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Sun Jul 04 14:41:20 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895298, encodeId=3b7f89529878, content=低脂不代表健康!食用<a href='/topic/show?id=21db630200b' target=_blank style='color:#2F92EE;'>#橄榄油#</a>、<a href='/topic/show?id=d04f4148924' target=_blank style='color:#2F92EE;'>#坚果#</a>和<a href='/topic/show?id=4c511028e37f' target=_blank style='color:#2F92EE;'>#鱼类#</a>,可显著改善<a href='/topic/show?id=99398953845' target=_blank style='color:#2F92EE;'>#血管内皮#</a>恢复稳态和再生!这些都是有益的零食!!适当的坚果,对健康相当有利, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63020, encryptionId=21db630200b, topicName=橄榄油), TopicDto(id=41489, encryptionId=d04f4148924, topicName=坚果), TopicDto(id=102873, encryptionId=4c511028e37f, topicName=鱼类), TopicDto(id=89538, encryptionId=99398953845, topicName=血管内皮)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:53:20 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=889273, encodeId=babb8892e3ba, content=收货良多, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ee15237778, createdName=147b43c6m81暂无昵称, createdTime=Tue Sep 29 20:07:27 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888232, encodeId=ccb68882323c, content=高血压、冠心病等心血管疾病(CVD)被列为全球头号死因,占我国居民疾病死亡构成的 40% 以上,目前我国心血管病患病人数已高达 2.9 亿。血管内皮功能障碍被普遍认为是心血管疾病风险的重要预测因子。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:37:45 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887949, encodeId=0e9188e9497b, content=该项研究表明,地中海饮食能更好地调节血管内皮功能,维持血管稳态环境,甚至增加再生内皮细胞能力。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Sep 24 14:15:11 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886865, encodeId=f5f7886865b0, content=科普文, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211221/3698211ff26948b5adc54b42c3637b7d/907441c2db554d41ad40a8f68b613640.jpg, createdBy=aa715419755, createdName=ms7000000098649996, createdTime=Sun Sep 20 14:51:57 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577745, encodeId=2a4d15e77457d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610708, encodeId=79e11610e083c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 20 12:41:20 CST 2020, time=2020-09-20, status=1, ipAttribution=)]
    2020-09-20 ms7000000098649996

    科普文

    0

  9. 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