JAMA Psychiatry:孕期抗抑郁药物暴露与新生儿出生缺陷

2020-08-11 MedSci原创 MedSci原创

孕妇是抑郁高风险人群,抗抑郁药物是有效的治疗手段,但抗抑郁药和特定新生儿出生缺陷风险之间的关系研究尚不充分。

孕妇是抑郁高风险人群,抗抑郁药物是有效的治疗手段,但抗抑郁药和特定新生儿出生缺陷风险之间的关系研究尚不充分。
 
国家出生缺陷预防研究为基于人口的多中心病例对照,1997年10月至2011年12月期间,从监测系统中选定特定的出生缺陷病例,对照组随机抽取无重大出生缺陷的活产婴儿,对孕期母亲抑郁药物服用情况进行考察。研究的主要终点为孕期抗抑郁药物暴露与出生缺陷的相关性。
 
研究包含30630名婴儿存在出生缺陷的产妇和11478名对照产妇。 统计发现,1562名新生儿存在出生缺陷的产妇(5.1%)和467名对照产妇(4.1%)在孕早期使用了抗抑郁药,其中观察到个别选择性5-羟色胺再摄取抑制剂(SSRIs)和先天性心脏缺陷(CHD)风险相关,例如使用氟西汀和肺静脉异常回流风险相关(OR:2.56,调整后相关性减弱,OR:1.89),观察到多种SSRI-CHD风险关系。 SSRIs与非CHD出生缺陷存在部分关联,如使用西酞普兰与膈疝风险相关(OR:5.11)。 文拉法辛与多种缺陷相关,调整后部分风险仍十分显著,如无脑畸形和颅骨(OR:9.14)。
 
研究发现,多种抗抑郁药物可导致新生儿缺陷风险增加。
 
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    2020-09-01 wetgdt
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1722525, encodeId=06b11e225252f, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Sep 01 02:33:21 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958114, encodeId=98d2195811494, content=<a href='/topic/show?id=4f2f8e771bc' target=_blank style='color:#2F92EE;'>#药物暴露#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87771, encryptionId=4f2f8e771bc, topicName=药物暴露)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Wed Aug 19 11:33:21 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792184, encodeId=b3da1e92184c7, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Thu Oct 22 13:33:21 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446706, encodeId=66c61446e0613, content=<a href='/topic/show?id=38bf553405a' target=_blank style='color:#2F92EE;'>#抗抑郁药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55340, encryptionId=38bf553405a, topicName=抗抑郁药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4bd5278649, createdName=huhuaidong389, createdTime=Thu Aug 13 10:33:21 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492260, encodeId=c09f14922605b, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Thu Aug 13 10:33:21 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807833, encodeId=63a780e83345, content=很有帮助的一个信息,谢谢小编。<a href='/topic/show?id=abe4452821f' target=_blank style='color:#2F92EE;'>#孕期使用抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45282, encryptionId=abe4452821f, topicName=孕期使用抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Aug 12 11:09:30 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807813, encodeId=8a6980e813ec, content=<a href='/topic/show?id=abe4452821f' target=_blank style='color:#2F92EE;'>#孕期使用抗抑郁药#</a> 在孕期,为了**的健康 ,最好不要服用抗抑郁药。在孕期,可以多外出散散步,晒晒太阳,这对情绪稳定和愉快的心情是有帮助的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45282, encryptionId=abe4452821f, topicName=孕期使用抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 12 11:07:31 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036217, encodeId=4e2d103621e20, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Tue Aug 11 22:33:21 CST 2020, time=2020-08-11, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1722525, encodeId=06b11e225252f, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Sep 01 02:33:21 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958114, encodeId=98d2195811494, content=<a href='/topic/show?id=4f2f8e771bc' target=_blank style='color:#2F92EE;'>#药物暴露#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87771, encryptionId=4f2f8e771bc, topicName=药物暴露)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Wed Aug 19 11:33:21 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792184, encodeId=b3da1e92184c7, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Thu Oct 22 13:33:21 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446706, encodeId=66c61446e0613, content=<a href='/topic/show?id=38bf553405a' target=_blank style='color:#2F92EE;'>#抗抑郁药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55340, encryptionId=38bf553405a, topicName=抗抑郁药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4bd5278649, createdName=huhuaidong389, createdTime=Thu Aug 13 10:33:21 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492260, encodeId=c09f14922605b, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Thu Aug 13 10:33:21 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807833, encodeId=63a780e83345, content=很有帮助的一个信息,谢谢小编。<a href='/topic/show?id=abe4452821f' target=_blank style='color:#2F92EE;'>#孕期使用抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45282, encryptionId=abe4452821f, topicName=孕期使用抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Aug 12 11:09:30 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807813, encodeId=8a6980e813ec, content=<a href='/topic/show?id=abe4452821f' target=_blank style='color:#2F92EE;'>#孕期使用抗抑郁药#</a> 在孕期,为了**的健康 ,最好不要服用抗抑郁药。在孕期,可以多外出散散步,晒晒太阳,这对情绪稳定和愉快的心情是有帮助的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45282, encryptionId=abe4452821f, topicName=孕期使用抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 12 11:07:31 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036217, encodeId=4e2d103621e20, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Tue Aug 11 22:33:21 CST 2020, time=2020-08-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1722525, encodeId=06b11e225252f, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Sep 01 02:33:21 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958114, encodeId=98d2195811494, content=<a href='/topic/show?id=4f2f8e771bc' target=_blank style='color:#2F92EE;'>#药物暴露#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87771, encryptionId=4f2f8e771bc, topicName=药物暴露)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Wed Aug 19 11:33:21 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792184, encodeId=b3da1e92184c7, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Thu Oct 22 13:33:21 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446706, encodeId=66c61446e0613, content=<a href='/topic/show?id=38bf553405a' target=_blank style='color:#2F92EE;'>#抗抑郁药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55340, encryptionId=38bf553405a, topicName=抗抑郁药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4bd5278649, createdName=huhuaidong389, createdTime=Thu Aug 13 10:33:21 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492260, encodeId=c09f14922605b, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Thu Aug 13 10:33:21 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807833, encodeId=63a780e83345, content=很有帮助的一个信息,谢谢小编。<a href='/topic/show?id=abe4452821f' target=_blank style='color:#2F92EE;'>#孕期使用抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45282, encryptionId=abe4452821f, topicName=孕期使用抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Aug 12 11:09:30 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807813, encodeId=8a6980e813ec, content=<a href='/topic/show?id=abe4452821f' target=_blank style='color:#2F92EE;'>#孕期使用抗抑郁药#</a> 在孕期,为了**的健康 ,最好不要服用抗抑郁药。在孕期,可以多外出散散步,晒晒太阳,这对情绪稳定和愉快的心情是有帮助的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45282, encryptionId=abe4452821f, topicName=孕期使用抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 12 11:07:31 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036217, encodeId=4e2d103621e20, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Tue Aug 11 22:33:21 CST 2020, time=2020-08-11, status=1, ipAttribution=)]
    2020-08-12 Jessica

    很有帮助的一个信息,谢谢小编。#孕期使用抗抑郁药#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1722525, encodeId=06b11e225252f, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Sep 01 02:33:21 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1958114, encodeId=98d2195811494, content=<a href='/topic/show?id=4f2f8e771bc' target=_blank style='color:#2F92EE;'>#药物暴露#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87771, encryptionId=4f2f8e771bc, topicName=药物暴露)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Wed Aug 19 11:33:21 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792184, encodeId=b3da1e92184c7, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Thu Oct 22 13:33:21 CST 2020, time=2020-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446706, encodeId=66c61446e0613, content=<a href='/topic/show?id=38bf553405a' target=_blank style='color:#2F92EE;'>#抗抑郁药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55340, encryptionId=38bf553405a, topicName=抗抑郁药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4bd5278649, createdName=huhuaidong389, createdTime=Thu Aug 13 10:33:21 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492260, encodeId=c09f14922605b, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Thu Aug 13 10:33:21 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807833, encodeId=63a780e83345, content=很有帮助的一个信息,谢谢小编。<a href='/topic/show?id=abe4452821f' target=_blank style='color:#2F92EE;'>#孕期使用抗抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45282, encryptionId=abe4452821f, topicName=孕期使用抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Aug 12 11:09:30 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807813, encodeId=8a6980e813ec, content=<a href='/topic/show?id=abe4452821f' target=_blank style='color:#2F92EE;'>#孕期使用抗抑郁药#</a> 在孕期,为了**的健康 ,最好不要服用抗抑郁药。在孕期,可以多外出散散步,晒晒太阳,这对情绪稳定和愉快的心情是有帮助的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45282, encryptionId=abe4452821f, topicName=孕期使用抗抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 12 11:07:31 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036217, encodeId=4e2d103621e20, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Tue Aug 11 22:33:21 CST 2020, time=2020-08-11, status=1, ipAttribution=)]
    2020-08-12 仁者大医

    #孕期使用抗抑郁药# 在孕期,为了**的健康 ,最好不要服用抗抑郁药。在孕期,可以多外出散散步,晒晒太阳,这对情绪稳定和愉快的心情是有帮助的。

    0

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    2020-08-11 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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