Ann Rheum Dis:接受靶向治疗的类风湿性关节炎患者疲劳预测因素

2021-08-15 MedSci原创 MedSci原创

早期RA患者的疲劳在疾病发作时普遍存在,在治疗期间迅速且持续地减少。基线时较低的客观疾病活动度和高PGA是24个月时临床相关疲劳的预测因素。

疲劳是类风湿性关节炎(RA)患者常见的症状,对其生活质量会产生很大影响。

近日,风湿病领域顶级期刊Annals of the Rheumatic Diseases上发表了一篇研究文章,研究人员旨在探讨早期RA患者在接受靶向治疗的最初24个月内疾病活动与疲劳之间的关联,以及24个月后疲劳的预测因素。

该研究的数据来自于一项靶向治疗、严格控制旨在缓解类风湿性关节炎的随机试验,该研究评估了超声在临床严格控制(ARCTIC)试验中的益处。疲劳是在视觉模拟量表(VAS)上测量的,范围从0到100mm,如果VAS≥20mm,则定义为具有临床意义。研究人员通过多变量Logisitc回归分析了24个月时疲劳的基线预测因素。

该研究纳入了205名在基线和24个月时有疲劳数据的患者。基线时,中位(第25、第75个百分位数)症状持续时间为5.4个月(2.8、10.4)、疲劳VAS为37.0mm(13.0、62.0)和平均疾病活动评分(DAS)为3.4(SD为1.1)。疲劳发生率从基线时的69%下降到24个月时的38%。肿胀的关节较少(OR为0.92,95%CI为0.87至0.98,p=0.006)、较低的能量多普勒超声评分(OR为0.95,95%CI为0.90至0.99,p=0.027)和较高的患者整体评估(PGA)(OR为1.03,95%CI为1.01至1.04,p<0.001))与24个月时临床相关疲劳风险增加相关。6个月时未达到缓解与24个月时较高的疲劳风险相关。
 
由此可见,早期RA患者的疲劳在疾病发作时普遍存在,在治疗期间迅速且持续地减少。基线时较低的客观疾病活动度和高PGA是24个月时临床相关疲劳的预测因素。

原始出处:

Karen Holten,et al.Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment.Ann Rheum Dis.2021.https://ard.bmj.com/content/early/2021/08/12/annrheumdis-2021-220750

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    2021-11-25 ms9000001578237549

    好文章学习了

    0

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    2021-08-17 tamgche
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    2021-08-17 lmm397
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    2021-08-15 tanxingdoctor

    谢谢!学习了

    0

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