JCEM:口服避孕药和更年期激素治疗与垂体腺瘤风险的关系

2021-12-05 MedSci原创 MedSci原创

与从不使用相比,当前和过去使用MHT以及使用MHT的持续时间较长与垂体腺瘤风险较高呈正相关。在前瞻性队列分析中使用OC与垂体腺瘤风险无关,在病例对照分析中仅与风险轻度增加相关。

目前,没有前瞻性流行病学研究评估使用口服避孕药(OC)或更年期激素治疗(MHT)与女性垂体腺瘤风险之间的关联。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员通过使用Cox比例风险模型计算使用OC/MHT后垂体腺瘤的多变量调整风险比(MVHR),并在护士健康研究和护士健康研究II中评估了OC/MHT与垂体腺瘤风险的关联。同时,研究人员使用机构数据存储库进行了匹配的病例对照研究,以通过OC/MHT计算垂体腺瘤的多变量调整比值比(MVOR)。

在6668019人次每年随访期间,331名参与者报告了垂体腺瘤。与从未使用过OC的人相比,过去(MVHR=1.05,95%CI为0.80-1.36)和当前使用OC(MVHR=0.72,95%CI为0.40-1.32)都与风险无关。对于MHT,与从未使用过的人相比,过去(MVHR=2.00,95%CI为1.50-2.68)和当前使用(MVHR=1.80,95%CI为1.27-2.55)MHT都与垂体腺瘤风险相关,治疗持续时间更长也是如此(与从未使用相比,使用时间超过5年的MVHR=2.06,95%CI为1.42-2.99,趋势p=0.002)。

当按BMI分层时,滞后分析的结果是相似的。在病例对照分析中,研究人员纳入了5469例病例。与从未使用MHT(MVOR=1.57,95%CI为1.35-1.83)和OC(MVOR=1.27,95%CI为1.14-1.42)相比,垂体腺瘤的风险增加。

由此可见,在两个独立数据集中,与从不使用相比,当前和过去使用MHT以及使用MHT的持续时间较长与垂体腺瘤风险较高呈正相关。在前瞻性队列分析中使用OC与垂体腺瘤风险无关,在病例对照分析中仅与风险轻度增加相关。

原始出处:

David J Cote.et al.Oral contraceptive and menopausal hormone therapy use and risk of pituitary adenoma: cohort and case-control analyses.JCEM.2021.https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab868/6448893

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    2022-06-29 achengzhao
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    2022-04-22 仁者大医
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077191, encodeId=85e710e719140, content=学了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Dec 05 23:15:01 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
  5. 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time=2021-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077257, encodeId=3e6310e7257e1, content=物性饮食与多种健康益处和有利的环境影响有关。对于前列腺癌,既往, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Mon Dec 06 08:59:31 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077226, encodeId=bbf210e722603, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0d7c1341677, createdName=50277, createdTime=Mon Dec 06 06:58:43 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077191, encodeId=85e710e719140, content=学了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Dec 05 23:15:01 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2021-12-07 chendoc244
  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077191, encodeId=85e710e719140, content=学了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Dec 05 23:15:01 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
  8. 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    2021-12-06 查查佳佳

    物性饮食与多种健康益处和有利的环境影响有关。对于前列腺癌,既往

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077191, encodeId=85e710e719140, content=学了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Dec 05 23:15:01 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2021-12-06 50277

    学习

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077191, encodeId=85e710e719140, content=学了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Dec 05 23:15:01 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2021-12-05 1209e435m98(暂无昵称)

    学了,谢谢分享

    0

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9月26日是世界避孕日。今年世界避孕日的主题是“高效避孕,孕育健康”。在常见的避孕方式里,大家比较熟悉的是口服避孕药。不过,有的朋友听说口服避孕药是1类致癌物,就不免有了疑惑,这1类致癌物能用来“高效避孕,孕育健康”吗?

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一个成熟的道德决策研究方法是使用道德困境情境,在这种情境中,潜在的行为过程违反了道德或功利规则。道德规则是建立在情境独立的道德规范和是非原则的基础上的。相比之下,功利主义规则依赖于情境,基于结果,有利

男性口服避孕药通过了初步安全测试

上周,美国FDA批准了史上第一款专治女性产后抑郁的新药投入临床使用,在美国乃至中国的潜在用户群体中引发了强烈反响。据说,该药物几期实验的效果都十分理想,大概唯一的遗憾就是非常之贵——一个疗程需要34000美元。

Circ Res:赖仞组揭示缺铁性贫血和口服避孕药诱导脑卒中分子机制

缺血性脑卒中通常是由血管阻塞引起的,约占中风的87%。简而言之,缺血性脑卒中是在血管阻塞引起的脑血流严重减少或中断后发生的。当前,缺血性脑卒中是全球第二大死因,也是永久性残疾的最重要原因。

Lancet:孕激素避孕药联合生殖教育对女性意外怀孕风险的影响

对于育龄女性,提供孕激素避孕药联合性健康和生殖健康教育可有效提高参与者的有效避孕率,降低意外怀孕风险