ATVB:普通人群血清钙化倾向与心血管及全因死亡风险

2020-06-06 MedSci原创 MedSci原创

普通人群血清T50与心血管死亡的风险增加独立相关,因此,T50可能是心血管疾病死亡早期且可改变的危险标志。

血管钙化是导致心血管疾病的原因。血清钙蛋白颗粒成熟时间(T50)是衡量钙化倾向的一种指标,与慢性肾脏病患者的不良结局有关,但尚不清楚其在普通人群中的作用。近日,心血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,研究人员旨在调查一个大型的以人群为基础的队列中血清T50是否与心血管疾病死亡率相关。

在肾脏和血管末期疾病预防(PREVEND)队列的6231名参与者中研究了血清T50与心血管死亡率之间的关系。全因死亡率是次要结局。

受试者平均(±SD)年龄为53±12岁,男性占50%,平均血清T50为329±58分钟。血清T50越短表明钙化倾向越高。血清T50与循环磷酸盐、年龄、估计的肾小球滤过率和酒精摄入呈负相关,而血浆镁与血清T50正相关(P<0.001,总多变量模型R2=0.281)。在中位(四分位间距)随访8.3(7.8-8.9)年期间,364例患者死亡(5.8%),其中95例(26.1%)患者因心血管原因死亡。在多变量Cox比例风险模型中,血清T50每降低60分钟与较高的心血管疾病死亡风险独立相关(完全调整的风险比[95%CI]为1.22 [1.04–1.36],P=0.021)。糖尿病改变了这种关联。分层分析表明糖尿病患者中这种关联更为明显。

由此可见,普通人群血清T50与心血管死亡的风险增加独立相关,因此,T50可能是心血管疾病死亡早期且可改变的危险标志。

原始出处:

Coby Eelderink.et al.Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population The PREVEND Study.ATVB.2020.https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.314187

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    2020-11-25 cy0324
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    2020-06-28 gongliu
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    2020-06-06 lovetcm

    血清钙蛋白颗粒成熟时间(T50)👍👍

    0

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