Acta Biomater:3D打印成功制备包含贝伐珠单抗和地塞米松局部递送的载药多壳棒

2021-08-02 MedSci原创 MedSci原创

视网膜血管疾病的临床治疗中,由于药物的半衰期短,需要反复进行玻璃体内注射,位患者带来了健康和经济负担。因此,有必要开发一种先进的药物输送系统,以延长药物的活性并尽量减少继发性并发症。

视网膜血管疾病的临床治疗中,由于药物的半衰期短,需要反复进行玻璃体内注射,位患者带来了健康和经济负担。因此,有必要开发一种先进的药物输送系统,以延长药物的活性并尽量减少继发性并发症。

近日,一项新的研究中,研究人员开发了一种芯/壳药物负载棒(药物棒),从单一植入物中输送两种药物(贝伐珠单抗(BEV)和地塞米松(DEX))。

 

同轴打印技术通过使用聚合物外壳和水凝胶核心,使BEV和DEX分别以不同的动力学在同一部位释放。3D技术可制备具有不同尺寸和药物浓度的药物棒,多层设计可以调整双重给药系统的释放曲线。使用小号针头将药棒无创地注射到大鼠玻璃体中。

此外,与传统的玻璃体内注射BEV相比,该研究制备的植入的药棒在抑制炎症反应和长期抑制新生血管方面的疗效,表明药棒可以成为治疗各种类型视网膜血管疾病的替代治疗方法。

 

原始出处:

 

Jae Yon Won, et al., 3D printing of drug-loaded multi-shell rods for local delivery of bevacizumab and dexamethasone: A synergetic therapy for retinal vascular diseases. Acta Biomater. 2020 Oct 15;116:174-185. doi: 10.1016/j.actbio.2020.09.015.  

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    2022-06-22 windight
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    2022-02-01 sunylz
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    2021-08-04 chg122
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