JNNP:慢性炎症性脱髓鞘性多发性神经根病中糖尿病和其他并发症的发生频率及其对临床表现和治疗反应的影响

2020-09-12 MedSci原创 MedSci原创

目的:确定慢性发炎性脱髓鞘性多发性神经根神经病(CIDP)中不同合并症的患病率及其对结局,治疗选择和反应的影响。

目的:确定慢性发炎性脱髓鞘性多发性神经根神经病(CIDP)中不同合并症的患病率及其对结局,治疗选择和反应的影响。

方法:采用结构化问卷,从意大利CIDP数据库中收集的393例符合欧洲神经病学会联合会和周围神经协会标准的CIDP患者中收集有关合并症的信息。

结果:294例患者(75%)报告了一种或多种合并症,192例患者(49%)报告了治疗方法,导致糖皮质激素的使用频率降低。百分之七十五(294)的患者报告至少一种并发症,而54%(214的患者)报告有两种以上并发症。 CIDP患者中的糖尿病(14%),MGUS(12%)和其他免疫性疾病(16%)的发生率明显高于欧洲普通人群。 在我们的人群中,动脉高血压(35%),血管疾病(11%),甲状腺疾病(11%)和实体瘤(9%)也很常见,但其患病率与意大利人群的报道没有明显差异。有192个(49%)患者出现了可能影响治疗选择的一种或多种并发症,而77例(19.5%)患者出现了两种或多种并发症。 与没有并发症的患者相比,在这些患者中较少使用皮质类固醇(49%比61%; p = 0.0199)。 两组之间在使用IVIg(74%vs 79%; p = 0.3407)和PEx(11%vs 9%; p = 0.6001),未接受治疗的患者数量(7%vs 8%)方面没有差异 ; p = 0.7044)。

结论:有75%的CIDP患者患有至少一种合并症,其中大约一半患有至少两种并发症。 这些数字高于其他研究报告的数字,在其他研究中,观察到的并发症发生率在25%至43%之间。最重要的是,大约一半的患者患有一种或多种并发症,可能会影响治疗的选择。 尽管在这些患者中较少使用类固醇疗法来避免增加副作用的危险CIDP患者并发症多见。CIDP患者的糖尿病,MGUS和其他免疫疾病比普通人群更常见。但是,只有糖尿病似乎对疾病的严重程度和治疗反应有影响,可能在某些患者中反映出糖尿病患者并存的神经病。

Doneddu PECocito DManganelli F, et al Frequency of diabetes and other comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy and their impact on clinical presentation and response to therapy

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    2021-06-23 丁鹏鹏
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    2021-01-30 jml2009
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    2020-09-13 向日葵

    很好的一篇文章

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1758285, encodeId=6a4f1e582859c, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Jun 23 02:11:37 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1890160, encodeId=3f60189016026, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sat Jan 30 14:11:37 CST 2021, time=2021-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756304, encodeId=65a01e56304a3, content=<a href='/topic/show?id=7414e433393' target=_blank style='color:#2F92EE;'>#神经根#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74333, encryptionId=7414e433393, topicName=神经根)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=806637100031, createdName=dzx0922901, createdTime=Sun Nov 29 01:11:37 CST 2020, time=2020-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755080, encodeId=b0b61e550805c, content=<a href='/topic/show?id=d1011021391e' target=_blank style='color:#2F92EE;'>#髓鞘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102139, encryptionId=d1011021391e, topicName=髓鞘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f28436833652, createdName=xiaogang329, createdTime=Mon Nov 16 16:11:37 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516411, encodeId=9d2f151641115, content=<a href='/topic/show?id=8160852e55c' target=_blank style='color:#2F92EE;'>#脱髓鞘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85275, encryptionId=8160852e55c, topicName=脱髓鞘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3ba10959947, createdName=1696533704_45270457, createdTime=Sun Sep 13 15:11:37 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547376, encodeId=54ae154e376ec, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Sun Sep 13 15:11:37 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884900, encodeId=4b2d884900c2, content=很好的一篇文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200913/a1324fa05148406c9efb22c724572cf2/07553ce8a7774195a1a4162648d1263a.jpg, createdBy=d56b5222777, createdName=向日葵, createdTime=Sun Sep 13 09:36:13 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043319, encodeId=1d5510433194f, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Sep 12 03:11:37 CST 2020, time=2020-09-12, status=1, ipAttribution=)]
    2020-09-12 misszhang

    谢谢MedSci提供最新的资讯

    0

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