Hepatology:在国际肝硬化队列中,饮食对肠道菌群的影响和对住院风险的调节是不同的

2018-07-27 MedSci MedSci原创

本研究表明,富含发酵牛奶、蔬菜、谷物、咖啡和茶的饮食与较高的微生物多样性有关。微生物多样性与90天住院治疗风险的降低有关。

研究背景:在高收入和中等收入国家中,肝硬化相关死亡的相对排名是不同的。肝硬化患者肠道菌群受影响,与饮食有关。本研究的目的是确定不同饮食习惯对肠道菌群和临床结果的影响。

研究方法:来自土耳其和美国的门诊代偿/失代偿肝硬化和对照患者进行了饮食和粪便菌群分析。对肝硬化患者进行随访,直到90天的住院治疗。在组内/组间对微生物多样性和住院治疗的Shannon多样性和多变量决定因素(Cox和二元逻辑关系)进行了研究。

研究结果:本研究共纳入296例患者(157例美国患者:48例对照,59例代偿期肝硬化患者,50例期肝硬化失代偿期患者;139例土耳其患者:46例健康对照,43例代偿期肝硬化患者,43例肝硬化失代偿期患者)。两组间的肝硬化患者在终末期肝病(MELD)评分上有相似的得分。美国肝硬化患者男性较多,利福昔单(rifaximin) /乳果糖(lactulose)使用较多,丙型肝炎/酒精病因较高。美国人的咖啡摄入量较高;而土耳其人的茶、发酵牛奶和巧克力的摄入量较高。整个土耳其群体的微生物多样性明显高于美国人,在健康对照组和肝硬化患者之间没有变化。相比之下,美国的微生物多样性却发生了变化,在失代偿期患者中,这一比例最低。咖啡、茶、蔬菜、巧克力和发酵牛奶的摄入量预示着更高的多样性;而MELD评分、乳果糖和碳酸饮料的使用预示着更低的微生物多样性。土耳其人90天住院治疗的风险较低。Cox和二元逻辑回归分析表明,微生物多样性与咖啡/茶、蔬菜和谷类食物的摄入量一样,对90天的住院有保护作用。

研究结论:本研究表明,富含发酵牛奶、蔬菜、谷物、咖啡和茶的饮食与较高的微生物多样性有关。微生物多样性与90天住院治疗风险的降低有关。

原始出处:

Bajaj JS, Idilman R, Mabudian L, et al. Diet affects gut microbiota and modulates hospitalization risk differentially in an international cirrhosis cohort. Hepatology, 2018, 68(1), 234-247.

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    2018-07-29 gwc384
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    2018-07-28 guging

    谢谢!最新的信息读起来就是收获大

    0

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